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EpCAM Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6295910

This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic… More details

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Product Overview

Online Datasheet in PDF
Product Name
EpCAM, Polyclonal Antibody
Full Product Name
EpCAM, CT (EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1, Epithelial cell adhesion molecule, Adenocarcinoma-associated antigen, Cell surface glycoprotein Trop-1, Epithelial cell surface antigen, Epithelial glycoprotein, Epithelial glycoprotein 314, KS
Product Gene Name
anti-EpCAM antibody
Product Synonym Names
EPCAM; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1; Epithelial cell adhesion molecule; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1; CD326
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
34,932 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (47596287..47614167). Location: 2p21
OMIM
185535
3D Structure
ModBase 3D Structure for P16422
Immunogen
EpCAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-229 amino acids from the C-terminal region of human EpCAM.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-EpCAM antibody

Antibodies; CD Markers
Applications Tested/Suitable for anti-EpCAM antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-EpCAM antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-EpCAM antibody

EpCAM Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the EpCAM antibody detected the EpCAM protein (arrow).
Rabbit Anti-EpCAM Polyclonal Antibody – Cat# MBS6295910

Product References and Citations for anti-EpCAM antibody

Kimura, O., et al. Cancer Sci. 101(10):2145-2155(2010). Jiang, L., et al. Breast Cancer Res. Treat. (2010). In press: Lugli, A., et al. Br. J. Cancer 103(3):382-390(2010). Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010): Ren, G., et al. Zhonghua Zhong Liu Za Zhi 31(11):841-844(2009).

Other Notes

Small volumes of anti-EpCAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EpCAM purchase

MBS6295910 is an antibody targeting EpCAM. Also known as EpCAM, CT (EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1, Epithelial cell adhesion molecule, Adenocarcinoma-associated antigen, Cell surface glycoprotein Trop-1, Epithelial cell surface antigen, Epithelial glycoprotein, Epithelial glycoprotein 314, KS. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EpCAM. It may not necessarily be applicable to this product.

NCBI GI #
218505670
NCBI GeneID
4072
NCBI Accession #
NP_002345.2
UniProt Primary Accession #
P16422
UniProt Secondary Accession #
P18180; Q6FG26; Q6FG49; Q96C47; Q9UCD0
UniProt Related Accession #
P16422
GenBank Nucleotide #
NM_002354.2
NCBI Official Full Name
epithelial cell adhesion molecule
NCBI Official Synonym Full Names
epithelial cell adhesion molecule
NCBI Official Symbol
EPCAM
NCBI Official Synonym Symbols
ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1
UniProt Protein Name
Epithelial cell adhesion molecule
UniProt Synonym Protein Names
Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; EGP; Epithelial glycoprotein 314; EGP314; hEGP314; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1
Protein Family
Epithelial cell adhesion molecule
UniProt Gene Name
EPCAM
UniProt Synonym Gene Names
GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1; Ep-CAM; EGP; EGP314; hEGP314
UniProt Entry Name
EPCAM_HUMAN
NCBI Protein Information
epithelial cell adhesion molecule; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated pro

UniProt Comments for EpCAM

EPCAM: a single-pass type I membrane protein of the EPCAM family. May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas including pancreatic carcinoma. May be a marker of cancer stem cells.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: tight junction; cell surface; basolateral plasma membrane; apical plasma membrane; integral to membrane; plasma membrane; lateral plasma membrane

Molecular Function: protein binding; protein complex binding

Biological Process: ureteric bud development; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; stem cell differentiation

Disease: Diarrhea 5, With Tufting Enteropathy, Congenital; Colorectal Cancer, Hereditary Nonpolyposis, Type 8
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Research Articles on EpCAM

1. LA carcinomas and carcinomas negative for basal markers were more often negative for epithelial cell adhesion molecule (Ep-CAM) and P-cadherin

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EpCAM antibody

 Reference Product  PubMed Publications
 CLDN7 antibody  >9 publications with EpCAM and CLDN7

Diseases associated with anti-EpCAM antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >758 publications with EpCAM and Neoplasms
 Carcinoma Antibodies  >449 publications with EpCAM and Carcinoma
 Neoplasm Metastasis Antibodies  >215 publications with EpCAM and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >188 publications with EpCAM and Adenocarcinoma
 Breast Neoplasms Antibodies  >155 publications with EpCAM and Breast Neoplasms
 Liver Neoplasms Antibodies  >104 publications with EpCAM and Liver Neoplasms
 Liver Diseases Antibodies  >100 publications with EpCAM and Liver Diseases
 Neoplasms, Experimental Antibodies  >84 publications with EpCAM and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >80 publications with EpCAM and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >78 publications with EpCAM and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-EpCAM antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >316 publications with EpCAM and Blood
 Liver Antibodies  >183 publications with EpCAM and Liver
 Lung Antibodies  >119 publications with EpCAM and Lung
 Prostate Antibodies  >66 publications with EpCAM and Prostate
 Lymph Node Antibodies  >48 publications with EpCAM and Lymph Node
 Ascites Antibodies  >44 publications with EpCAM and Ascites
 Stomach Antibodies  >42 publications with EpCAM and Stomach
 Kidney Antibodies  >40 publications with EpCAM and Kidney
 Intestine Antibodies  >37 publications with EpCAM and Intestine
 Vascular Antibodies  >31 publications with EpCAM and Vascular
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