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EphA7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6296017

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in… More details

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Product Overview

Online Datasheet in PDF
Product Name
EphA7, Polyclonal Antibody
Full Product Name
EphA7, CT (EPHA7, EHK3, HEK11, Ephrin type-A receptor 7, EPH homology kinase 3, EPH-like kinase 11) (PE)
Product Gene Name
anti-EphA7 antibody
Product Synonym Names
EPHA7; EHK3; HEK11; Ephrin type-A receptor 7; EPH homology kinase 3; EPH-like kinase 11
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein G Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
112,097 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (93949738..94129300, complement). Location: 6q16.1
OMIM
602190
3D Structure
ModBase 3D Structure for Q15375
Immunogen
EphA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 904~933 amino acids from the C-terminal region of human EphA7.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-EphA7 antibody

Antibodies; Protein Kinases
Applications Tested/Suitable for anti-EphA7 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-EphA7 antibody
IHC: 1:50-100
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-EphA7 antibody

Western blot analysis of anti-EphA7 Pab in NCI-H460 cell lysate. EphA7 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Rabbit Anti-EphA7 Polyclonal Antibody – Cat# MBS6296017

Western Blot (WB) of anti-EphA7 antibody

Western blot analysis of EPHA7 (arrow) using EphA7 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EPHA7 gene (Lane 2) (Origene Technologies).
Rabbit Anti-EphA7 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6296017

Immunohistochemistry (IHC) of anti-EphA7 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-EphA7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6296017

Product References and Citations for anti-EphA7 antibody

Wilkinson, D.G., Nat Rev Neurosci 2(3):155-164 (2001). Xu, Q., et al., Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355(1399):993-1002 (2000). Holder, N., et al., Development 126(10):2033-2044 (1999). Zhou, R., Pharmacol. Ther. 77(3):151-181 (1998). Fox, G.M., et al., Oncogene 10(5):897-905 (1995).

Other Notes

Small volumes of anti-EphA7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EphA7 purchase

MBS6296017 is an antibody targeting EphA7. Also known as EphA7, CT (EPHA7, EHK3, HEK11, Ephrin type-A receptor 7, EPH homology kinase 3, EPH-like kinase 11) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EphA7. It may not necessarily be applicable to this product.

NCBI GI #
4758282
NCBI GeneID
2045
NCBI Accession #
NP_004431.1
UniProt Primary Accession #
Q15375
UniProt Secondary Accession #
Q59G40; Q5VTU0; Q8N368; Q9H124; A0AUX7; B2R8W1; B7ZLJ9; B7ZLK0
UniProt Related Accession #
Q15375
GenBank Nucleotide #
NM_004440.3
NCBI Official Full Name
ephrin type-A receptor 7
NCBI Official Synonym Full Names
EPH receptor A7
NCBI Official Symbol
EPHA7
NCBI Official Synonym Symbols
EHK3; HEK11
UniProt Protein Name
Ephrin type-A receptor 7
UniProt Synonym Protein Names
EPH homology kinase 3; EHK-3; EPH-like kinase 11
Protein Family
Ephrin type-A receptor
UniProt Gene Name
EPHA7
UniProt Synonym Gene Names
EHK3; HEK11; EHK-3; EK11; hEK11
UniProt Entry Name
EPHA7_HUMAN
NCBI Protein Information
ephrin type-A receptor 7; EK11; EHK-3; EPH-like kinase 11; EPH homology kinase 3; Eph homology kinase-3; receptor protein-tyrosine kinase HEK11; tyrosine-protein kinase receptor EHK-3

NCBI Summary for EphA7

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
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UniProt Comments for EphA7

EphA7: a widely-expressed receptor tyrosine kinase of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A2, -A3, -A4 and -A5. Contains 1 sterile alpha motif (SAM) and two fibronectin type III domains.

Protein type: Protein kinase, TK; Membrane protein, integral; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Eph family

Chromosomal Location of Human Ortholog: 6q16.1

Cellular Component: postsynaptic membrane; cell soma; integral to plasma membrane; dendrite; plasma membrane; neuromuscular junction

Molecular Function: protein binding; ephrin receptor binding; chemorepellent activity; protein-tyrosine kinase activity; GPI-linked ephrin receptor activity; axon guidance receptor activity; ATP binding

Biological Process: axon guidance; regulation of cell-cell adhesion; peptidyl-tyrosine phosphorylation; branching morphogenesis of a nerve; regulation of protein amino acid autophosphorylation; positive regulation of neuron apoptosis; ephrin receptor signaling pathway; negative chemotaxis; brain development; regulation of caspase activity; phosphorylation; regulation of peptidyl-tyrosine phosphorylation; retinal ganglion cell axon guidance
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Research Articles on EphA7

1. The expression of EphA7 and/or MTDH might be closely related to the carcinogenesis, progression, clinical biological behaviors and prognosis of gallbladder adenocarcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EphA7 antibody

 Reference Product  PubMed Publications
 MLLT4 antibody  >2 publications with EphA7 and MLLT4
 EFNA5 antibody  >1 publications with EphA7 and EFNA5
 EFNA3 antibody  >1 publications with EphA7 and EFNA3

Pathways associated with anti-EphA7 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
 EphrinA-EPHA Pathway antibodies  EphrinA-EPHA Pathway Diagram

Diseases associated with anti-EphA7 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >30 publications with EphA7 and Neoplasms
 Immune System Diseases Antibodies  >6 publications with EphA7 and Immune System Diseases
 Nervous System Diseases Antibodies  >6 publications with EphA7 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >4 publications with EphA7 and Congenital Abnormalities
 Nervous System Malformations Antibodies  >3 publications with EphA7 and Nervous System Malformations
 Necrosis Antibodies  >3 publications with EphA7 and Necrosis
 Breast Neoplasms Antibodies  >2 publications with EphA7 and Breast Neoplasms
 Genital Diseases, Male Antibodies  >2 publications with EphA7 and Genital Diseases, Male
 Cardiovascular Diseases Antibodies  >2 publications with EphA7 and Cardiovascular Diseases
 Pain Antibodies  >2 publications with EphA7 and Pain

Organs/Tissues associated with anti-EphA7 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >54 publications with EphA7 and Brain
 Eye Antibodies  >16 publications with EphA7 and Eye
 Embryonic Tissue Antibodies  >16 publications with EphA7 and Embryonic Tissue
 Vascular Antibodies  >8 publications with EphA7 and Vascular
 Bone Antibodies  >6 publications with EphA7 and Bone
 Ear Antibodies  >6 publications with EphA7 and Ear
 Lung Antibodies  >6 publications with EphA7 and Lung
 Muscle Antibodies  >4 publications with EphA7 and Muscle
 Kidney Antibodies  >3 publications with EphA7 and Kidney
 Prostate Antibodies  >3 publications with EphA7 and Prostate
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