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EPOR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6003503

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
EPOR, Polyclonal Antibody
Full Product Name
EPOR, ID (EPOR, Erythropoietin receptor)
Product Gene Name
anti-EPOR antibody
Product Synonym Names
Anti -EPOR, ID (EPOR, Erythropoietin receptor)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
55,065 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (11487881..11495018, complement). Location: 19p13.3-p13.2
OMIM
133100
3D Structure
ModBase 3D Structure for P19235
Immunogen
EPOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 328-357 amino acids from the Central region of human EPOR.

Product Categories/Family for anti-EPOR antibody

Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-EPOR antibody
ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes for anti-EPOR antibody
Suitable for use in Western Blot, Immunofluorescence, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Flow Cytometry: 1:10-50
Immunofluorescence: 1:10-50

Western Blot (WB) of anti-EPOR antibody

Western Blot analysis in NCI-H460 cell line lysates (35ug/lane) using MBS6003503. This demonstrates that MBS6003503 detected the EPOR protein (arrow).
Rabbit Anti-EPOR Polyclonal Antibody – Cat# MBS6003503

Immunofluorescence (IF) of anti-EPOR antibody

Confocal immunofluorescent analysis with Hela cells using MBS6003503 followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-EPOR Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6003503

Testing Data of anti-EPOR antibody

Rabbit Anti-EPOR Polyclonal Antibody, Testing Data – Cat# MBS6003503

Other Notes

Small volumes of anti-EPOR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EPOR purchase

MBS6003503 is an antibody targeting EPOR. Also known as EPOR, ID (EPOR, Erythropoietin receptor). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EPOR. It may not necessarily be applicable to this product.

NCBI GI #
4503591
NCBI GeneID
2057
NCBI Accession #
NP_000112.1
UniProt Primary Accession #
P19235
UniProt Secondary Accession #
Q15443; Q2M205; B2RCG4
UniProt Related Accession #
P19235
GenBank Nucleotide #
NM_000121.3
NCBI Official Full Name
erythropoietin receptor
NCBI Official Synonym Full Names
erythropoietin receptor
NCBI Official Symbol
EPOR
NCBI Official Synonym Symbols
EPO-R
UniProt Protein Name
Erythropoietin receptor
Protein Family
Erythropoietin receptor
UniProt Gene Name
EPOR
UniProt Synonym Gene Names
EPO-R
UniProt Entry Name
EPOR_HUMAN
NCBI Protein Information
erythropoietin receptor

UniProt Comments for EPOR

EPOR: erythropoietin receptor: a member of the cytokine receptor family. Mediates erythropoietin-induced erythroblast proliferation, differentiation and survival. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. Forms homodimers on EPO stimulation. Tyrosine-phosphorylated EpoR may bind several SH2 domain-containing proteins including LYN, the adapter protein APS, SHP-1, SHP-2, JAK2, PI3 kinases, STAT5A/B, SOCS3, and CRKL. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Three alternatively-spliced isoforms have been described. Isoform EPOR-T, missing the cytoplasmic tail, acts as a dominant-negative receptor of EPOR-mediated signaling.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: integral to plasma membrane; extracellular region

Molecular Function: identical protein binding; protein binding; erythropoietin receptor activity

Biological Process: heart development; decidualization; brain development; signal transduction

Disease: Erythrocytosis, Familial, 1
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Research Articles on EPOR

1. molecular classification of breast cancer is based upon the expression of ESR, PGR and HER2; the expression of EPOR, membrane receptor GPER and EPHB4 may be considered as an additional classification factor in breast cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EPOR antibody

 Reference Product  PubMed Publications
 EPO antibody  >671 publications with EPOR and EPO
 JAK2 antibody  >178 publications with EPOR and JAK2
 PTPN6 antibody  >13 publications with EPOR and PTPN6
 GRB2 antibody  >9 publications with EPOR and GRB2
 SOCS3 antibody  >8 publications with EPOR and SOCS3
 SOCS2 antibody  >6 publications with EPOR and SOCS2
 CRKL antibody  >6 publications with EPOR and CRKL
 LYN antibody  >5 publications with EPOR and LYN

Pathways associated with anti-EPOR antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
 EPO Signaling Pathway antibodies  EPO Signaling Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram

Diseases associated with anti-EPOR antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >240 publications with EPOR and Neoplasms
 Anemia Antibodies  >155 publications with EPOR and Anemia
 Polycythemia Antibodies  >73 publications with EPOR and Polycythemia
 Cardiovascular Diseases Antibodies  >66 publications with EPOR and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >56 publications with EPOR and Disease Models, Animal
 Kidney Diseases Antibodies  >30 publications with EPOR and Kidney Diseases
 Neoplasms, Experimental Antibodies  >29 publications with EPOR and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >29 publications with EPOR and Breast Neoplasms
 Necrosis Antibodies  >27 publications with EPOR and Necrosis
 Inflammation Antibodies  >22 publications with EPOR and Inflammation

Organs/Tissues associated with anti-EPOR antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >326 publications with EPOR and Blood
 Bone Antibodies  >124 publications with EPOR and Bone
 Brain Antibodies  >103 publications with EPOR and Brain
 Kidney Antibodies  >76 publications with EPOR and Kidney
 Liver Antibodies  >67 publications with EPOR and Liver
 Heart Antibodies  >41 publications with EPOR and Heart
 Embryonic Tissue Antibodies  >32 publications with EPOR and Embryonic Tissue
 Lung Antibodies  >24 publications with EPOR and Lung
 Eye Antibodies  >22 publications with EPOR and Eye
 Skin Antibodies  >11 publications with EPOR and Skin
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