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ERAP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1753653

Endoplasmic reticulum aminopeptidase 2 is a protein that in humans is encoded by the ERAP2 gene. This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic… More details

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Product Overview

Online Datasheet in PDF
Product Name
ERAP2, Polyclonal Antibody
Full Product Name
Anti-ERAP2 Antibody
Product Gene Name
anti-ERAP2 antibody
Product Synonym Names
ERAP2; LRAP; Endoplasmic reticulum aminopeptidase 2; EC 3. 4. 11. -; Leukocyte-derived arginine aminopeptidase; L-RAP; endoplasmic reticulum aminopeptidase 2
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized. Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.
Purity/Purification
Immunogen affinity purified.
Specificity
Rabbit IgG polyclonal antibody for ERAP2 detection.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
Predicted: 106 kDa

Observed: 120kDa
OMIM
609497
3D Structure
ModBase 3D Structure for Q6P179
Immunogen
E Coli-derived human ERAP2 recombinant protein (Position: K13-T960).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Recommended Detection Systems
Recommended Detection Systems||Lab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (MBS176460) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (MBS176453) for IHC(P).
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-ERAP2 antibody
Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), Flow Cytometry (FC/FACS/FCM), Direct ELISA (EIA)
Application Notes for anti-ERAP2 antibody
WB: 0.25-0.5ug/ml|Human|
IHC-P: 2-5ug/ml|Human|
FC/FACS/FCM: 1-3ug/1x106 cells|Human|
Direct ELISA: 0.1-0.5ug/ml|Human|

Product References and Citations for anti-ERAP2 antibody

1. Cagliani, R., Riva, S., Biasin, M., Fumagalli, M., Pozzoli, U., Lo Caputo, S., Mazzotta, F., Piacentini, L., Bresolin, N., Clerici, M., Sironi, M. Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection. Hum. Molec. Genet. 19: 4705-4714, 2010.
2. Saveanu, L., Carroll, O., Lindo, V., Del Val, M., Lopez, D., Lepelletier, Y., Greer, F., Schomburg, L., Fruci, D., Niedermann, G., van Endert, P. M. Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Nature Immun. 6: 689-697, 2005.
3. Tanioka, T., Hattori, A., Masuda, S., Nomura, Y., Nakayama, H., Mizutani, S., Tsujimoto, M. Human leukocyte-derived arginine aminopeptidase: the third member of the oxytocinase subfamily of aminopeptidases. J. Biol. Chem. 278: 32275-32283, 2003.

Other Notes

Small volumes of anti-ERAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ERAP2 purchase

MBS1753653 is an antibody targeting ERAP2. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ERAP2. It may not necessarily be applicable to this product.

NCBI GI #
11641261
NCBI GeneID
64167
NCBI Accession #
NP_071745
UniProt Primary Accession #
Q6P179
UniProt Secondary Accession #
Q7Z5K1; Q8TD32; Q8WVJ4; Q9HBX2
UniProt Related Accession #
Q6P179
GenBank Nucleotide #
NM_022350.3
NCBI Official Full Name
endoplasmic reticulum aminopeptidase 2
NCBI Official Synonym Full Names
endoplasmic reticulum aminopeptidase 2
NCBI Official Symbol
ERAP2
NCBI Official Synonym Symbols
LRAP; L-RAP
UniProt Protein Name
Endoplasmic reticulum aminopeptidase 2
UniProt Synonym Protein Names
Leukocyte-derived arginine aminopeptidase; L-RAP
Protein Family
Endoplasmic reticulum aminopeptidase
UniProt Gene Name
ERAP2
UniProt Synonym Gene Names
LRAP; L-RAP
UniProt Entry Name
ERAP2_HUMAN
NCBI Protein Information
endoplasmic reticulum aminopeptidase 2; leukocyte-derived arginine aminopeptidase

NCBI Summary for ERAP2

Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 (MIM 606832) and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2; MIM 190470) (Tanioka et al., 2003 [PubMed 12799365]).[supplied by OMIM, Mar 2008]
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UniProt Comments for ERAP2

ERAP2: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. Belongs to the peptidase M1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Protease; EC 3.4.11.-; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 5q15

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen; integral to membrane

Molecular Function: metallopeptidase activity; zinc ion binding; aminopeptidase activity

Biological Process: antigen processing and presentation of peptide antigen via MHC class I; regulation of blood pressure; proteolysis; antigen processing and presentation of endogenous peptide antigen via MHC class I
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Research Articles on ERAP2

1. Data indicate that dimerization of endoplasmic reticulum aminopeptidases ERAP1/2 creates complexes with superior peptide-trimming efficacy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ERAP2 antibody

 Reference Product  PubMed Publications
 HLA-B antibody  >6 publications with ERAP2 and HLA-B
 HLA-A antibody  >2 publications with ERAP2 and HLA-A

Pathways associated with anti-ERAP2 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram

Diseases associated with anti-ERAP2 antibody

 Disease Name  Pubmed Publications
 Crohn Disease Antibodies  >4 publications with ERAP2 and Crohn Disease
 Inflammation Antibodies  >3 publications with ERAP2 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >2 publications with ERAP2 and Cell Transformation, Neoplastic
 Necrosis Antibodies  >2 publications with ERAP2 and Necrosis
 Kidney Diseases Antibodies  >2 publications with ERAP2 and Kidney Diseases
 Carcinoma, Squamous Cell Antibodies  >1 publications with ERAP2 and Carcinoma, Squamous Cell
 Central Nervous System Diseases Antibodies  >1 publications with ERAP2 and Central Nervous System Diseases
 Kidney Neoplasms Antibodies  >1 publications with ERAP2 and Kidney Neoplasms
 Congenital Abnormalities Antibodies  >1 publications with ERAP2 and Congenital Abnormalities
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with ERAP2 and Drug-Related Side Effects and Adverse Reactions

Organs/Tissues associated with anti-ERAP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >17 publications with ERAP2 and Blood
 Muscle Antibodies  >5 publications with ERAP2 and Muscle
 Placenta Antibodies  >3 publications with ERAP2 and Placenta
 Embryonic Tissue Antibodies  >3 publications with ERAP2 and Embryonic Tissue
 Kidney Antibodies  >2 publications with ERAP2 and Kidney
 Vascular Antibodies  >2 publications with ERAP2 and Vascular
 Eye Antibodies  >2 publications with ERAP2 and Eye
 Uterus Antibodies  >2 publications with ERAP2 and Uterus
 Liver Antibodies  >1 publications with ERAP2 and Liver
 Pancreas Antibodies  >1 publications with ERAP2 and Pancreas
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