Rabbit Anti-ERCC6L Polyclonal Antibody – Cat# MBS6008102

Western Blot analysis of ERCC6L expression in transfected 293T cell line by ERCC6L polyclonal antibody. Lane 1: ERCC6L transfected lysate (46.2kD). Lane 2: Non-transfected lysate.

ERCC6L Antibody – Rabbit Polyclonal

Name: ERCC6L Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6008102
Price: 970 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6008102

DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with… More details

$970 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ERCC6L, Polyclonal Antibody

Full Product Name

ERCC6L (DNA Excision Repair Protein ERCC-6-like, ATP-dependent Helicase ERCC6-like, PLK1-interacting Checkpoint Helicase, Tumor Antigen BJ-HCC-15, PICH, FLJ20105, MGC131695)

Product Gene Name

anti-ERCC6L antibody

Product Synonym Names

Anti -ERCC6L (DNA Excision Repair Protein ERCC-6-like, ATP-dependent Helicase ERCC6-like, PLK1-interacting Checkpoint Helicase, Tumor Antigen BJ-HCC-15, PICH, FLJ20105, MGC131695)

Immunogen Sequence

MEKSFATKNE AVQKETLQEG PKQEALQEDP LESFNYVLSK STKADIGPNL DQLKDDEILR HCNPWPIISI TNESQNAESN VSIIEIADDL SASHSALQDA QASEAKLEEE PSASSPQYAC DFNLFLEDSA DNRQNFSSQS LEHVEKENSL CGSAPNSRAG FVHSKTCLSW EFSEKDDEPE EVVVKAKIRS KARRIVSDGE DEDDSFKDTS SINPFNTSLF QFSSVKQFDA STPKNDISPP GRFFSSQIPS SVNKSMNSRR SLASRRSLIN MVLDHVEDME ERLDDSSEAK GPEDYPEEGV EESSGEASKY TEEDPSGETL SSENKSSWLM TSKPSALAQE TSLGAPEPLS GEQLVGSPQD KAAEATNDYE TLVKRGKELK ECGKIQEALN CLVKALDIKS ADPEVMLLTL SLYKQLNNN

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human ERCC6L.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap/

Molecular Weight

141,103 Da

Chromosome Location

Chromosome: X; NC_000023.10 (71424507..71458877, complement). Location: Xq13.1

OMIM

300687

3D Structure

ModBase 3D Structure for Q2NKX8

Immunogen

Full length human ERCC6L, aa1-419 (AAH08808.1).

Product Categories/Family for anti-ERCC6L antibody

Antibodies; Abs to Cell Cycle Inhibitors

Applications Tested/Suitable for anti-ERCC6L antibody

Western Blot (WB)

Application Notes for anti-ERCC6L antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-ERCC6L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ERCC6L purchase

MBS6008102 is an antibody targeting ERCC6L. Also known as ERCC6L (DNA Excision Repair Protein ERCC-6-like, ATP-dependent Helicase ERCC6-like, PLK1-interacting Checkpoint Helicase, Tumor Antigen BJ-HCC-15, PICH, FLJ20105, MGC131695). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ERCC6L. It may not necessarily be applicable to this product.

NCBI GI #

211830500

NCBI GeneID

54821

NCBI Accession #

AAH08808.2

UniProt Primary Accession #

Q2NKX8

UniProt Secondary Accession #

Q8NCI1; Q96H93; Q9NXQ8

UniProt Related Accession #

Q2NKX8

NCBI Official Full Name

ERCC6L protein

NCBI Official Synonym Full Names

excision repair cross-complementing rodent repair deficiency, complementation group 6-like

NCBI Official Symbol

ERCC6L

NCBI Official Synonym Symbols

PICH; RAD26L

UniProt Protein Name

DNA excision repair protein ERCC-6-like

UniProt Synonym Protein Names

ATP-dependent helicase ERCC6-like; PLK1-interacting checkpoint helicase; Tumor antigen BJ-HCC-15

Protein Family

DNA excision repair protein

UniProt Gene Name

ERCC6L

UniProt Synonym Gene Names

PICH

UniProt Entry Name

ERC6L_HUMAN

NCBI Protein Information

DNA excision repair protein ERCC-6-like; tumor antigen BJ-HCC-15; SNF2/RAD54 family protein; ATP-dependent helicase ERCC6-like; excision repair protein ERCC6-like; Plk1-interacting checkpoint helicase; excision repair cross-complementing rodent repair deficiency complementation group 6 - like

UniProt Comments for ERCC6L

PICH: DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Interacts with PLK1, which phosphorylates it. Both proteins are mutually dependent on each other for correct subcellular localization. Belongs to the SNF2/RAD54 helicase family.

Protein type: EC 3.6.4.12; Helicase

Chromosomal Location of Human Ortholog: Xq13.1

Cellular Component: nucleoplasm; centrosome; membrane; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; DNA binding; helicase activity; ATP binding

Biological Process: mitosis; cell division; metabolic process; mitotic cell cycle

Research Articles on ERCC6L

1. PICH protein was required for the correct recruitment to the centromere of active topoisomerase IIalpha, an enzyme specialized in the catenation/decatenation process.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ERCC6L antibody

Reference Product	PubMed Publications
PLK1 antibody	>8 publications with ERCC6L and PLK1
BLM antibody	>3 publications with ERCC6L and BLM
CDK1 antibody	>1 publications with ERCC6L and CDK1
RMI1 antibody	>1 publications with ERCC6L and RMI1

Pathways associated with anti-ERCC6L antibody

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
M Phase Pathway antibodies	M Phase Pathway Diagram
Mitotic Anaphase Pathway antibodies	Mitotic Anaphase Pathway Diagram
Mitotic Metaphase And Anaphase Pathway antibodies	Mitotic Metaphase And Anaphase Pathway Diagram
Mitotic Prometaphase Pathway antibodies	Mitotic Prometaphase Pathway Diagram
PLK1 Signaling Events Pathway antibodies	PLK1 Signaling Events Pathway Diagram
Resolution Of Sister Chromatid Cohesion Pathway antibodies	Resolution Of Sister Chromatid Cohesion Pathway Diagram
Separation Of Sister Chromatids Pathway antibodies	Separation Of Sister Chromatids Pathway Diagram

Diseases associated with anti-ERCC6L antibody

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>1 publications with ERCC6L and Disease Models, Animal

Organs/Tissues associated with anti-ERCC6L antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>2 publications with ERCC6L and Lung
Kidney Antibodies	>2 publications with ERCC6L and Kidney
Liver Antibodies	>2 publications with ERCC6L and Liver
Uterus Antibodies	>1 publications with ERCC6L and Uterus
Brain Antibodies	>1 publications with ERCC6L and Brain