ERVWE1 Antibody – Rabbit Polyclonal

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Zhao, J., et al. BMC Med. Genet. 11, 96 (2010): Oppelt, P., et al. Gynecol. Endocrinol. 25(11):741-747(2009). Gimenez, J., et al. DNA Res. 16(4):195-211(2009). Larsen, J.M., et al. Cancer Lett. 280(1):44-49(2009). Noorali, S., et al. Appl. Immunohistochem. Mol. Morphol. 17(4):319-328(2009).

Small volumes of anti-ERVWE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6296698 is an antibody targeting ERVWE1. Also known as ERVWE1, CT (ERVW-1, ERVWE1, HERV-W_7q21.2 provirus ancestral Env polyprotein, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, Syncytin, Syncytin-1, Surface protein, gp5. Reactive in Human. Host: Rabbit.