• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

ESR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6474975

MBS6474975 is an antibody targeting ESR2. Also known as ESR2, ID (Estrogen Receptor beta, ER-beta, Nuclear Receptor Subfamily 3 Group A Member 2, NR3A2, ESTRB, ESR2) (MaxLight 650). Reactive in Human. Host: Rabbit. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ESR2, Polyclonal Antibody
Full Product Name
ESR2, ID (Estrogen Receptor beta, ER-beta, Nuclear Receptor Subfamily 3 Group A Member 2, NR3A2, ESTRB, ESR2) (MaxLight 650)
Product Gene Name
anti-ESR2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Immunoaffinity chromatography.
Specificity
Recognizes human ESR2. Expected to cross-react with bovine, chicken, porcine and rat due to sequence homology.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
53,209 Da
OMIM
601663
3D Structure
ModBase 3D Structure for Q92731
Immunogen
KLH-conjugated synthetic peptide corresponding to a portion of amino acids encompassed by aa 369-397 of human ESR2.
Conjugate
MaxLight650
Note
Preservative Free

Product Categories/Family for anti-ESR2 antibody

Antibodies; Receptors; Estrogen
Applications Tested/Suitable for anti-ESR2 antibody
Flow Cytometry (FC/FACS), FLISA, Western Blot (WB)
Application Notes for anti-ESR2 antibody
FC/FACS: 1:10-1:50
FLISA: 1:1000
WB: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ESR2 antibody

Western blot analysis of MCF-7 cell line lysates (35ug/lane) usingMBS626994.
Rabbit Anti-ESR2 Polyclonal Antibody – Cat# MBS6474975

Flow Cytometry (FC/FACS) of anti-ESR2 antibody

Flow cytometric analysis of HepG2 cells using MBS626994 (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibody was used for the analysis.
Rabbit Anti-ESR2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6474975

Product References and Citations for anti-ESR2 antibody

1. Chen H., Lin R.J.Cell 90:569-580(1997). 2. Caira F., Antonson P.J. Biol. Chem. 275:5308-5317(2000). 3. Bu H., Kashireddy P.Biochem. Biophys. Res. Commun. 317:54-59(2004).

Other Notes

Small volumes of anti-ESR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ESR2. It may not necessarily be applicable to this product.

NCBI GI #
10835013
NCBI GeneID
2100
NCBI Accession #
NP_001428
UniProt Primary Accession #
Q92731
UniProt Secondary Accession #
O60608; O60685; O60702; O60703; O75583; O75584; Q0MWT5; Q0MWT6; Q86Z31; A8K8K5; G3V5M5
UniProt Related Accession #
Q92731
GenBank Nucleotide #
NM_001437
NCBI Official Full Name
estrogen receptor beta isoform 1
NCBI Official Synonym Full Names
estrogen receptor 2 (ER beta)
NCBI Official Symbol
ESR2
NCBI Official Synonym Symbols
Erb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA
UniProt Protein Name
Estrogen receptor beta
UniProt Synonym Protein Names
Nuclear receptor subfamily 3 group A member 2
Protein Family
Estrogen receptor
UniProt Gene Name
ESR2
UniProt Synonym Gene Names
ESTRB; NR3A2; ER-beta
UniProt Entry Name
ESR2_HUMAN
NCBI Protein Information
estrogen receptor beta; estrogen receptor beta 4; nuclear receptor subfamily 3 group A member 2

UniProt Comments for ESR2

ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 14q23.2

Cellular Component: nucleoplasm; mitochondrion; extracellular region; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; receptor antagonist activity; protein binding; estrogen receptor activity; enzyme binding; DNA binding; zinc ion binding; transcription coactivator activity; estrogen response element binding; steroid hormone receptor activity; transcription factor activity; steroid binding

Biological Process: transcription initiation from RNA polymerase II promoter; estrogen receptor signaling pathway; induction of apoptosis by hormones; neuron migration; vagina development; negative regulation of transcription from RNA polymerase II promoter; uterus development; signal transduction; cell-cell signaling; ovarian follicle development; regulation of transcription, DNA-dependent; steroid hormone mediated signaling; positive regulation of transcription factor activity; gene expression; brain development; negative regulation of cell growth; negative regulation of epithelial cell proliferation
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ESR2 antibody

 Products by Pathway  Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Ovarian Infertility Genes Pathway antibodies  Ovarian Infertility Genes Pathway Diagram
 Plasma Membrane Estrogen Receptor Signaling Pathway antibodies  Plasma Membrane Estrogen Receptor Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram

Diseases associated with anti-ESR2 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >32 publications with ESR2 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >30 publications with ESR2 and Cardiovascular Diseases
 Genital Diseases, Male Antibodies  >25 publications with ESR2 and Genital Diseases, Male
 Colorectal Neoplasms Antibodies  >15 publications with ESR2 and Colorectal Neoplasms
 Endometriosis Antibodies  >14 publications with ESR2 and Endometriosis
 Infertility, Male Antibodies  >14 publications with ESR2 and Infertility, Male
 Infertility, Female Antibodies  >12 publications with ESR2 and Infertility, Female
 Congenital Abnormalities Antibodies  >11 publications with ESR2 and Congenital Abnormalities
 Carcinoma Antibodies  >10 publications with ESR2 and Carcinoma
 Hypertension Antibodies  >10 publications with ESR2 and Hypertension

Organs/Tissues associated with anti-ESR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >42 publications with ESR2 and Brain
 Testis Antibodies  >31 publications with ESR2 and Testis
 Lung Antibodies  >5 publications with ESR2 and Lung
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000