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ESRRB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150845

ESRRB Antibody: The estrogen-related receptor beta (ESRRB) was initially identified in mouse embryonic carcinoma stem cells and was found to be expressed exclusively in trophoblast progenitor cells between days 6.5 and 7.5 post coitum. Recent studies have… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
ESRRB, Polyclonal Antibody
Full Product Name
ESRRB Antibody
Product Gene Name
anti-ESRRB antibody
Product Synonym Names
ESRRB; ERR2; ERRb; ESRL2; NR3B2; DFNB35; ERRB2; Steroid hormone receptor ERR2; ERR beta-2; ERR-beta; estrogen-related receptor beta
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
ESRRB Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
ESRRB antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
ESRRB peptide (MBS153057) is used for blocking the activity of ESRRB antibody (MBS150845)
OMIM
gene 608565
3D Structure
ModBase 3D Structure for O95718
Conjugate
Unconjugated
Immunogen
ESRRB antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human ESRRB.
Buffer
ESRRB Antibody is supplied in PBS containing 0.02% sodium azide.
Positive Control
MBS151755
Homology
Predicted species reactivity based on immunogen sequence: Mouse (89%), Rat (89%)
Applications Tested/Suitable for anti-ESRRB antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-ESRRB antibody
ESRRB antibody can be used for detection of ESRRB by Western blot at 1 ug/mL. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 5 ug/mL.
Optimal dilutions for each application to be determined by the researcher.

Western Blot (WB) of anti-ESRRB antibody

ESRRB Antibody.
Rabbit Anti-ESRRB Polyclonal Antibody – Cat# MBS150845

Immunohistochemistry (IHC) of anti-ESRRB antibody

Immunohistochemistry of ESRR8 in human heart tissue with ESRR8 antibody at 5 μg/mL.
Rabbit Anti-ESRRB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150845

Immunofluorescence (IF) of anti-ESRRB antibody

Immunofluorescence of ESRRB in human heart tissue with ESRRB antibody at 20 μg/mL.
Rabbit Anti-ESRRB Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150845

Other Notes

Small volumes of anti-ESRRB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ESRRB purchase

MBS150845 is an antibody targeting ESRRB. Also known as ESRRB Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ESRRB. It may not necessarily be applicable to this product.

NCBI GI #
238550159
NCBI GeneID
2103
NCBI Accession #
NP_004443
UniProt Primary Accession #
O95718
UniProt Secondary Accession #
Q5F0P7; Q5F0P8; Q9HCB4; A2VDJ2; B6ZGU4
UniProt Related Accession #
O95718
GenBank Nucleotide #
NM_004452.3
NCBI Official Full Name
steroid hormone receptor ERR2
NCBI Official Synonym Full Names
estrogen-related receptor beta
NCBI Official Symbol
ESRRB
NCBI Official Synonym Symbols
ERR2; ERRb; ESRL2; NR3B2; DFNB35
UniProt Protein Name
Steroid hormone receptor ERR2
UniProt Synonym Protein Names
ERR beta-2; Estrogen receptor-like 2; Estrogen-related receptor beta; ERR-beta; Nuclear receptor subfamily 3 group B member 2
Protein Family
Steroid hormone receptor
UniProt Gene Name
ESRRB
UniProt Synonym Gene Names
ERRB2; ESRL2; NR3B2; ERR-beta
UniProt Entry Name
ERR2_HUMAN
NCBI Protein Information
steroid hormone receptor ERR2; ERR-beta; ERRbeta-2; ERR beta-2; nuclear receptor ERRB2; orphan nuclear receptor; estrogen receptor-like 2; estrogen-related nuclear receptor beta; nuclear receptor subfamily 3 group B member 2

NCBI Summary for ESRRB

This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008]

UniProt Comments for ESRRB

ERR2: Nuclear receptor, may regulate ESR1 transcriptional activity. Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35). DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the nuclear hormone receptor family. NR3 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; zinc ion binding; sequence-specific DNA binding; transcription coactivator activity; steroid hormone receptor activity; transcription factor binding; steroid binding

Biological Process: transcription initiation from RNA polymerase II promoter; embryonic placenta development; trophectodermal cell proliferation; intracellular receptor-mediated signaling pathway; regulation of transcription, DNA-dependent; stem cell maintenance; trophectodermal cellular morphogenesis; positive regulation of transcription from RNA polymerase II promoter; gene expression; steroid hormone mediated signaling

Disease: Deafness, Autosomal Recessive 35
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Research Articles on ESRRB

1. study concludes ESRRB, a gene when mutated causes a form of hearing impairment, also contributes to dental decay likely by influencing the formation of an enamel surface more susceptible to demineralization under acidic conditions

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ESRRB antibody

 Reference Product  PubMed Publications
 NANOG antibody  >38 publications with ESRRB and NANOG
 OCT4 antibody  >32 publications with ESRRB and OCT4
 POU5F1 antibody  >18 publications with ESRRB and POU5F1
 ESR1 antibody  >2 publications with ESRRB and ESR1
 NR5A1 antibody  >1 publications with ESRRB and NR5A1
 ESRRA antibody  >1 publications with ESRRB and ESRRA
 NR0B2 antibody  >1 publications with ESRRB and NR0B2

Pathways associated with anti-ESRRB antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Wnt Signaling Pathway And Pluripotency antibodies  Wnt Signaling Pathway And Pluripotency Diagram

Diseases associated with anti-ESRRB antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >5 publications with ESRRB and Carcinoma
 Prostatic Neoplasms Antibodies  >2 publications with ESRRB and Prostatic Neoplasms
 Adenocarcinoma Antibodies  >2 publications with ESRRB and Adenocarcinoma
 Urinary Bladder Neoplasms Antibodies  >1 publications with ESRRB and Urinary Bladder Neoplasms
 Hyperinsulinism Antibodies  >1 publications with ESRRB and Hyperinsulinism
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with ESRRB and Prenatal Exposure Delayed Effects
 Endometrial Neoplasms Antibodies  >1 publications with ESRRB and Endometrial Neoplasms

Organs/Tissues associated with anti-ESRRB antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with ESRRB and Brain
 Kidney Antibodies  >4 publications with ESRRB and Kidney
 Mixed Antibodies  >3 publications with ESRRB and Mixed
 Connective Tissue Antibodies  >3 publications with ESRRB and Connective Tissue
 Muscle Antibodies  >3 publications with ESRRB and Muscle
 Testis Antibodies  >2 publications with ESRRB and Testis
 Eye Antibodies  >2 publications with ESRRB and Eye
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