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EXOC5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6475378

MBS6475378 is an antibody targeting EXOC5. Also known as EXOC5, CT (Exocyst Complex Component Sec10, hSec10, Exocyst Complex Component 5, SEC10, SEC10L1) (Azide free) (HRP). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
EXOC5, Polyclonal Antibody
Full Product Name
EXOC5, CT (Exocyst Complex Component Sec10, hSec10, Exocyst Complex Component 5, SEC10, SEC10L1) (Azide free) (HRP)
Product Gene Name
anti-EXOC5 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Immunoaffinity chromatography.
Specificity
Recognizes human EXOC5.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
81,853 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (57669194..57735617, complement). Location: 14q22.3
OMIM
604469
3D Structure
ModBase 3D Structure for O00471
Immunogen
Synthetic peptide selected from the C-terminal region of human EXOC5 (KLH).
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-EXOC5 antibody

Antibodies; Transport Proteins
Applications Tested/Suitable for anti-EXOC5 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-EXOC5 antibody
WB: 1:100-1:500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-EXOC5 antibody

Western blot analysis of EXOC5 Antibody (C-term) in NCI-H460 cell line lysates (35ug/lane). EXOC5 (arrow) was detected using the purified Pab.
Rabbit Anti-EXOC5 Polyclonal Antibody – Cat# MBS6475378

Immunohistochemistry (IHC) of anti-EXOC5 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma reacted with EXOC5 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-EXOC5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6475378

Flow Cytometry (FC/FACS) of anti-EXOC5 antibody

EXOC5 Antibody (C-term) flow cytometric analysis of NCI-H460 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-EXOC5 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6475378

Product References and Citations for anti-EXOC5 antibody

1. Kee, Y., et.al., Proc. Natl. Acad. Sci. USA 94(26), 14438-14443 (1997). 2. Hsu, S.C., et.al., Neuron 20(6), 1111-1122 (1998).

Other Notes

Small volumes of anti-EXOC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EXOC5. It may not necessarily be applicable to this product.

NCBI GI #
5730037
NCBI GeneID
10640
NCBI Accession #
NP_006535.1
UniProt Primary Accession #
O00471
UniProt Secondary Accession #
B2R6C5
UniProt Related Accession #
O00471; Q658M3; Q8IW24; Q9UHT0
GenBank Nucleotide #
NM_006544.3
NCBI Official Full Name
exocyst complex component 5
NCBI Official Synonym Full Names
exocyst complex component 5
NCBI Official Symbol
EXOC5
NCBI Official Synonym Symbols
SEC10; HSEC10; SEC10P; PRO1912; SEC10L1; DKFZp666H126
UniProt Protein Name
Exocyst complex component 5
UniProt Synonym Protein Names
Exocyst complex component Sec10
Protein Family
Exocyst complex component
UniProt Gene Name
EXOC5
UniProt Synonym Gene Names
SEC10; SEC10L1
UniProt Entry Name
EXOC5_HUMAN
NCBI Protein Information
exocyst complex component 5; SEC10-like 1; exocyst complex component Sec10

NCBI Summary for EXOC5

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq]
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UniProt Comments for EXOC5

EXOC5: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC10 family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 14q22.3

Cellular Component: cytoplasm; cytosol

Molecular Function: Ral GTPase binding; protein N-terminus binding

Biological Process: protein transport; vesicle docking; exocytosis; cellular protein metabolic process; organelle organization and biogenesis; post-Golgi vesicle-mediated transport
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Research Articles on EXOC5

1. Exocyst Sec10 overexpression reduces damage to tubular epithelial barriers caused by hydrogen peroxide and speeds the recovery of normal epithelial barrier function after such an injury.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-EXOC5 antibody

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Diseases associated with anti-EXOC5 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with EXOC5 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with EXOC5 and Neoplasm Metastasis

Organs/Tissues associated with anti-EXOC5 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >5 publications with EXOC5 and Kidney
 Blood Antibodies  >1 publications with EXOC5 and Blood
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