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F10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6475508

MBS6475508 is an antibody targeting F10. Also known as F10, CT (Coagulation Factor X, Stuart Factor, Stuart-Prower Factor, Factor X Light Chain, Factor X Heavy Chain, Activated Factor Xa Heavy Chain) (MaxLight 490). Reactive in Human. Host: Rabbit. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
F10, Polyclonal Antibody
Full Product Name
F10, CT (Coagulation Factor X, Stuart Factor, Stuart-Prower Factor, Factor X Light Chain, Factor X Heavy Chain, Activated Factor Xa Heavy Chain) (MaxLight 490)
Product Gene Name
anti-F10 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human F10.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
54,732 Da
OMIM
227600
3D Structure
ModBase 3D Structure for P00742
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 351-381 in the C-terminal region of human F10, UniProt Accession #P00742.
Conjugate
MaxLight490
Note
Preservative Free

Product Categories/Family for anti-F10 antibody

Antibodies; Proteins
Applications Tested/Suitable for anti-F10 antibody
Immunohistochemistry (IHC) Paraffin, Flow Cytometry (FC/FACS), Western Blot (WB), FLISA
Application Notes for anti-F10 antibody
IHC-P: 1:50-1:100
FC/FACS: 1:10-1:50
WB: 1:1000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-F10 antibody

Western blot analysis of 293 cell line lysates (35ug/lane) using F0019-40. F10 (arrow) was detected using the purified Pab.
Rabbit Anti-F10 Polyclonal Antibody – Cat# MBS6475508

Immunohistochemistry (IHC) of anti-F10 antibody

IHC analysis of in formalin fixed and paraffin embedded human hepatocarcinoma using F0019-40 followed by peroxidase conjugation of the secondary antibody and DAB staining.
Rabbit Anti-F10 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6475508

Flow Cytometry (FC/FACS) of anti-F10 antibody

Flow cytometric analysis of 293 cells (right histogram) using F0019-40 compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-F10 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6475508

Product References and Citations for anti-F10 antibody

1. Alba, R., Blood 114(5), 965-971 (2009). 2. Borensztajn, K., Thromb. Res. 124(2), 219-225 (2009). 3. Larson, P.J., Biochemistry 37(14), 5029-5038 (1998).

Other Notes

Small volumes of anti-F10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for F10. It may not necessarily be applicable to this product.

NCBI GI #
4503625
NCBI GeneID
2159
NCBI Accession #
NP_000495
UniProt Primary Accession #
P00742
UniProt Secondary Accession #
Q14340
UniProt Related Accession #
P00742
GenBank Nucleotide #
NM_000504
NCBI Official Full Name
coagulation factor X preproprotein
NCBI Official Synonym Full Names
coagulation factor X
NCBI Official Symbol
F10
NCBI Official Synonym Symbols
FX; FXA
UniProt Protein Name
Coagulation factor X
UniProt Synonym Protein Names
Stuart factor; Stuart-Prower factor
Protein Family
Coagulation factor
UniProt Gene Name
F10
UniProt Entry Name
FA10_HUMAN
NCBI Protein Information
coagulation factor X; Stuart-Prower factor; factor Xa; prothrombinase

UniProt Comments for F10

F10: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Defects in F10 are the cause of factor X deficiency (FA10D). A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis. Belongs to the peptidase S1 family.

Protein type: Secreted, signal peptide; Lipid-binding; Secreted; Motility/polarity/chemotaxis; EC 3.4.21.6; Protease

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: endoplasmic reticulum lumen; Golgi lumen; extracellular region; plasma membrane

Molecular Function: protein binding; serine-type endopeptidase activity; phospholipid binding; calcium ion binding

Biological Process: positive regulation of protein kinase B signaling cascade; blood coagulation, extrinsic pathway; cellular protein metabolic process; blood coagulation; proteolysis; post-translational protein modification; blood coagulation, intrinsic pathway; peptidyl-glutamic acid carboxylation; positive regulation of cell migration

Disease: Factor X Deficiency
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-F10 antibody

 Reference Product  PubMed Publications
 TFPI antibody  >2 publications with F10 and TFPI
 PLG antibody  >1 publications with F10 and PLG

Pathways associated with anti-F10 antibody

 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Extrinsic Pathway antibodies  Extrinsic Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway antibodies  Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway Diagram
 Gamma-carboxylation Of Protein Precursors Pathway antibodies  Gamma-carboxylation Of Protein Precursors Pathway Diagram
 Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies  Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram

Diseases associated with anti-F10 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1023 publications with F10 and Neoplasms
 Lung Neoplasms Antibodies  >296 publications with F10 and Lung Neoplasms
 Drug Toxicity Antibodies  >77 publications with F10 and Drug Toxicity
 Nervous System Diseases Antibodies  >73 publications with F10 and Nervous System Diseases
 Necrosis Antibodies  >60 publications with F10 and Necrosis
 Liver Neoplasms Antibodies  >40 publications with F10 and Liver Neoplasms
 Brain Diseases Antibodies  >34 publications with F10 and Brain Diseases
 Inflammation Antibodies  >32 publications with F10 and Inflammation
 Liver Diseases Antibodies  >32 publications with F10 and Liver Diseases
 Liver Neoplasms, Experimental Antibodies  >30 publications with F10 and Liver Neoplasms, Experimental

Organs/Tissues associated with anti-F10 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >431 publications with F10 and Blood
 Lung Antibodies  >411 publications with F10 and Lung
 Skin Antibodies  >129 publications with F10 and Skin
 Brain Antibodies  >96 publications with F10 and Brain
 Liver Antibodies  >86 publications with F10 and Liver
 Spleen Antibodies  >64 publications with F10 and Spleen
 Embryonic Tissue Antibodies  >52 publications with F10 and Embryonic Tissue
 Muscle Antibodies  >49 publications with F10 and Muscle
 Kidney Antibodies  >44 publications with F10 and Kidney
 Ovary Antibodies  >30 publications with F10 and Ovary
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