Rabbit Anti-FAIM3 Polyclonal Antibody – Cat# MBS6378009

Western Blot analysis of FAIM3 expression in transfected 293T cell line by FAIM3 polyclonal antibody. Lane 1: FAIM3 transfected lysate (42.9kD). Lane 2: Non-transfected lysate.

FAIM3 Antibody – Rabbit Polyclonal

Name: FAIM3 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6378009
Price: 1040 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6378009

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha-and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation… More details

$1040 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FAIM3, Polyclonal Antibody

Full Product Name

FAIM3 (Fas Apoptotic Inhibitory Molecule 3, Regulator of Fas-induced Apoptosis Toso, TOSO) (AP)

Product Gene Name

anti-FAIM3 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Specificity

Recognizes human FAIM3.

Preparation and Storage

Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

OMIM

606015

3D Structure

ModBase 3D Structure for O60667

Immunogen

Full length human FAIM3, aa1-390 (NP_005440.1)

Immunogen Sequence

MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHVRIYLCREMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVYACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALDYGSQSGREGQGFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA

Conjugate

Note

Preservative Free

Product Categories/Family for anti-FAIM3 antibody

Antibodies; Apoptosis

Applications Tested/Suitable for anti-FAIM3 antibody

Western Blot (WB)

Application Notes for anti-FAIM3 antibody

Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-FAIM3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FAIM3 purchase

MBS6378009 is an antibody targeting FAIM3. Also known as FAIM3 (Fas Apoptotic Inhibitory Molecule 3, Regulator of Fas-induced Apoptosis Toso, TOSO) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FAIM3. It may not necessarily be applicable to this product.

NCBI GI #

1519314052

NCBI GeneID

9214

NCBI Accession #

NM_005449.5

UniProt Primary Accession #

O60667

UniProt Related Accession #

O60667

GenBank Nucleotide #

NM_005449

NCBI Official Full Name

Homo sapiens Fc fragment of IgM receptor (FCMR), transcript variant 1, mRNA

NCBI Official Synonym Full Names

Fc fragment of IgM receptor

NCBI Official Symbol

FCMR

NCBI Official Synonym Symbols

TOSO; FAIM3

UniProt Protein Name

Fas apoptotic inhibitory molecule 3

UniProt Synonym Protein Names

Regulator of Fas-induced apoptosis Toso

UniProt Gene Name

FAIM3

UniProt Synonym Gene Names

TOSO

UniProt Entry Name

FAIM3_HUMAN

NCBI Protein Information

fas apoptotic inhibitory molecule 3

NCBI Summary for FAIM3

Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]

UniProt Comments for FAIM3

FAIM3: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: extracellular region; integral to membrane

Biological Process: immune system process; cellular defense response; negative regulation of apoptosis

Research Articles on FAIM3

1. We conclude that glutamine at position 510 in Cmu4 is critical for IgM binding to FcmuR. This will facilitate discrimination between the distinct effects of FcmuR interactions with soluble IgM and with the IgM BCR.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.