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FANCC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6378107

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FANCC, Polyclonal Antibody
Full Product Name
FANCC (Fanconi Anemia Group C Protein, Protein FACC, FAC, FACC) (PE)
Product Gene Name
anti-FANCC antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human FANCC.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
63,429 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (97861336..98079991, complement). Location: 9q22.3
OMIM
phenotype 613899
3D Structure
ModBase 3D Structure for Q00597
Immunogen
Full length human FANCC, aa1-558 (NP_000127.2).
Immunogen Sequence
MAQDSVDLSCDYQFWMQKLSVWDQASTLETQQDTCLHVAQFQEFLRKMYEALKEMDSNTVIERFPTIGQLLAKACWNPFILAYDESQKILIWCLCCLINKEPQNSGQSKLNSWIQGVLSHILSALRFDKEVALFTQGLGYAPIDYYPGLLKNMVLSLASELRENHLNGFNTQRRMAPERVASLSRVCVPLITLTDVDPLVEALLICHGREPQEILQPEFFEAVNEAILLKKISLPMSAVVCLWLRHLPSLEKAMLHLFEKLISSERNCLRRIECFIKDSSLPQAACHPAIFRVVDEMFRCALLETDGALEIIATIQVFTQCFVEALEKASKQLRFALKTYFPYTSPSLAMVLLQDPQDIPRGHWLQTLKHISELLREAVEDQTHGSCGGPFESWFLFIHFGGWAEMVAEQLLMSAAEPPTALLWLLAFYYGPRDGRQQRAQTMVQVKAVLGHLLAMSRSSSLSAQDLQTVAGQGTDTDLRAPAQQLIRHLLLNFLLWAPGGHTIAWDVITLMAHTAEITHEIIGFLDQTLYRWNRLGIESPRSEKLARELLKELRTQV
Conjugate
PE
Note
Preservative Free

Product Categories/Family for anti-FANCC antibody

Antibodies; DNA Repair/Damage
Applications Tested/Suitable for anti-FANCC antibody
Western Blot (WB)
Application Notes for anti-FANCC antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-FANCC antibody

FANCC rabbit polyclonal antibody. Western Blot analysis of FANCC expression in human kidney.
Rabbit Anti-FANCC Polyclonal Antibody – Cat# MBS6378107

Western Blot (WB) of anti-FANCC antibody

Western Blot analysis of FANCC expression in transfected 293T cell line by FANCC polyclonal antibody. Lane 1: FANCC transfected lysate (63.4kD). Lane 2: Non-transfected lysate.
Rabbit Anti-FANCC Polyclonal Antibody, Western Blot (WB) – Cat# MBS6378107

Other Notes

Small volumes of anti-FANCC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FANCC purchase

MBS6378107 is an antibody targeting FANCC. Also known as FANCC (Fanconi Anemia Group C Protein, Protein FACC, FAC, FACC) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FANCC. It may not necessarily be applicable to this product.

NCBI GI #
56118236
NCBI GeneID
2176
NCBI Accession #
NP_000127.2
UniProt Primary Accession #
Q00597
UniProt Secondary Accession #
B1ALR8
UniProt Related Accession #
Q00597
GenBank Nucleotide #
NM_000136.2
NCBI Official Full Name
Fanconi anemia group C protein isoform a
NCBI Official Synonym Full Names
Fanconi anemia, complementation group C
NCBI Official Symbol
FANCC
NCBI Official Synonym Symbols
FA3; FAC; FACC
UniProt Protein Name
Fanconi anemia group C protein
Protein Family
Fanconi anemia group C protein
UniProt Gene Name
FANCC
UniProt Synonym Gene Names
FAC; FACC; Protein FACC
UniProt Entry Name
FANCC_HUMAN
NCBI Protein Information
Fanconi anemia group C protein

UniProt Comments for FANCC

FANCC: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. Defects in FANCC are the cause of Fanconi anemia complementation group C (FANCC). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.

Chromosomal Location of Human Ortholog: 9q22.3

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein binding

Biological Process: removal of superoxide radicals; nucleotide-excision repair; myeloid cell homeostasis; protein complex assembly; DNA repair; germ cell development

Disease: Fanconi Anemia, Complementation Group C; Tracheoesophageal Fistula With Or Without Esophageal Atresia
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FANCC antibody

 Reference Product  PubMed Publications
 FANCA antibody  >95 publications with FANCC and FANCA
 FANCG antibody  >90 publications with FANCC and FANCG
 FANCD2 antibody  >71 publications with FANCC and FANCD2
 FANCF antibody  >45 publications with FANCC and FANCF
 FANCE antibody  >35 publications with FANCC and FANCE
 STAT1 antibody  >7 publications with FANCC and STAT1
 GSTP1 antibody  >3 publications with FANCC and GSTP1

Pathways associated with anti-FANCC antibody

 Products by Pathway  Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram

Diseases associated with anti-FANCC antibody

 Disease Name  Pubmed Publications
 Anemia Antibodies  >243 publications with FANCC and Anemia
 Fanconi Anemia Antibodies  >242 publications with FANCC and Fanconi Anemia
 Neoplasms Antibodies  >37 publications with FANCC and Neoplasms
 Leukemia Antibodies  >34 publications with FANCC and Leukemia
 Necrosis Antibodies  >27 publications with FANCC and Necrosis
 Chromosome Aberrations Antibodies  >24 publications with FANCC and Chromosome Aberrations
 Congenital Abnormalities Antibodies  >19 publications with FANCC and Congenital Abnormalities
 Carcinoma Antibodies  >17 publications with FANCC and Carcinoma
 Leukemia, Myeloid Antibodies  >17 publications with FANCC and Leukemia, Myeloid
 Leukemia, Myeloid, Acute Antibodies  >12 publications with FANCC and Leukemia, Myeloid, Acute

Organs/Tissues associated with anti-FANCC antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >105 publications with FANCC and Bone
 Liver Antibodies  >7 publications with FANCC and Liver
 Lung Antibodies  >7 publications with FANCC and Lung
 Ovary Antibodies  >5 publications with FANCC and Ovary
 Testis Antibodies  >5 publications with FANCC and Testis
 Embryonic Tissue Antibodies  >3 publications with FANCC and Embryonic Tissue
 Brain Antibodies  >3 publications with FANCC and Brain
 Kidney Antibodies  >2 publications with FANCC and Kidney
 Connective Tissue Antibodies  >1 publications with FANCC and Connective Tissue
 Stomach Antibodies  >1 publications with FANCC and Stomach
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