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FAT4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8590634

FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by gamma secretase to… More details

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Product Overview

Online Datasheet in PDF
Product Name
FAT4, Polyclonal Antibody
Full Product Name
FAT4 Antibody
Product Gene Name
Product Synonym Names
FATJ; FAT-J; CDHF14; CDHR11; NBLA00548
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Purity/Purification
Antigen affinity purification.
Specificity
The antibody detects endogenous levels of total FAT4 protein.
Preparation and Storage
Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze/thaw cycles.
Molecular Weight
542,616 Da
OMIM
612411
3D Structure
ModBase 3D Structure for Q6V0I7
Immunogen
Synthetic peptide corresponding to residues near the C terminal of human FAT tumor suppressor homolog 4 (Drosophila)

Product Categories/Family for anti-FAT4 antibody

ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-FAT4 antibody
Immunohistochemistry (IHC)
Application Notes for anti-FAT4 antibody
IHC: 1:25-1:100

Other Notes

Small volumes of anti-FAT4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FAT4 purchase

MBS8590634 is an antibody targeting FAT4. Also known as FAT4 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FAT4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
protocadherin Fat 4 isoform 2
NCBI Official Synonym Full Names
FAT atypical cadherin 4
NCBI Official Symbol
FAT4
NCBI Official Synonym Symbols
FATJ; FAT-J; CDHF14; CDHR11; HKLLS2; VMLDS2; NBLA00548
UniProt Protein Name
Protocadherin Fat 4
UniProt Synonym Protein Names
Cadherin family member 14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J
Protein Family
UniProt Gene Name
FAT4
UniProt Synonym Gene Names
CDHF14; FATJ; hFat4
UniProt Entry Name
FAT4_HUMAN
NCBI Protein Information
protocadherin Fat 4

NCBI Summary for FAT4

The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014]
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UniProt Comments for FAT4

FAT4: May function in the regulation of planar cell polarity. Cadherins are cell-cell interaction molecules. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q28.1

Cellular Component: apical part of cell; plasma membrane; integral to membrane

Molecular Function: protein binding; calcium ion binding

Biological Process: heart morphogenesis; heterophilic cell adhesion; inner ear receptor stereocilium organization and biogenesis; plasma membrane organization and biogenesis; neurogenesis; gut development; ureteric bud branching; cerebral cortex development; homophilic cell adhesion

Disease: Van Maldergem Syndrome 2; Hennekam Lymphangiectasia-lymphedema Syndrome 2
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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