Fatty Acid Synthase (FASN) Antibody – Rabbit Polyclonal

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]

FASN: a multifunctional enzyme. Catalyzes the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.

Protein type: EC 3.1.2.14; EC 2.3.1.38; Hydrolase; EC 4.2.1.59; Oxidoreductase; EC 1.3.1.39; EC 2.3.1.85; EC 2.3.1.41; EC 2.3.1.39; Lipid Metabolism - fatty acid biosynthesis; EC 1.1.1.100; Lyase; Acetyltransferase

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: cytoplasm; cytosol; glycogen granule; Golgi apparatus; melanosome; membrane; mitochondrion; plasma membrane

Molecular Function: 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; 3-oxoacyl-[acyl-carrier-protein] reductase activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; [acyl-carrier-protein] S-acetyltransferase activity; [acyl-carrier-protein] S-malonyltransferase activity; drug binding; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; fatty-acid synthase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; protein binding; protein homodimerization activity

Biological Process: acetyl-CoA metabolic process; cellular lipid metabolic process; energy reserve metabolic process; fatty acid biosynthetic process; fatty acid metabolic process; mammary gland development; osteoblast differentiation; pantothenate metabolic process; positive regulation of cellular metabolic process; triacylglycerol biosynthetic process; vitamin metabolic process; water-soluble vitamin metabolic process