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FCER1A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3207682

This is a rabbit polyclonal antibody against FCER1A. It was validated on Western Blot using a cell lysate as a positive control.Target Description: The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the… More details

$490 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FCER1A, Polyclonal Antibody
Full Product Name
FCER1A antibody - N-terminal region
Product Gene Name
anti-FCER1A antibody
Product Synonym Gene Name
FCE1A; FcERI
Immunogen Sequence
Synthetic peptide located within the following region: NPPWNRIFKG ENVTLTCNGN NFFEVSSTKW FHNGSLSEET NSSLNIVNAK
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
FCER1A peptide (MBS3232648) is used for blocking the activity of FCER1A antibody (MBS3207682)
Molecular Weight
27kDa
OMIM
147140
3D Structure
ModBase 3D Structure for P12319
Homology
Human: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human FCER1A

Product Categories/Family for anti-FCER1A antibody

Polyclonal; Membrane Protein; Cell Biology; E3 & Ubiquitin; Membrane & Traffic; Disease Related; Phosphorylation
Applications Tested/Suitable for anti-FCER1A antibody
Western Blot (WB)

Western Blot (WB) of anti-FCER1A antibody

WB Suggested Anti-FCER1A Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: 721_B cell lysate
Rabbit Anti-FCER1A Polyclonal Antibody – Cat# MBS3207682

Other Notes

Small volumes of anti-FCER1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FCER1A purchase

MBS3207682 is an antibody targeting FCER1A. Also known as FCER1A antibody - N-terminal region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FCER1A. It may not necessarily be applicable to this product.

NCBI GI #
4503675
NCBI GeneID
2205
NCBI Accession #
NP_001992
UniProt Primary Accession #
P12319
UniProt Related Accession #
P12319
GenBank Nucleotide #
NM_002001
NCBI Official Full Name
high affinity immunoglobulin epsilon receptor subunit alpha
NCBI Official Synonym Full Names
Fc fragment of IgE receptor Ia
NCBI Official Symbol
FCER1A
NCBI Official Synonym Symbols
FCE1A; FcERI
UniProt Protein Name
High affinity immunoglobulin epsilon receptor subunit alpha
UniProt Synonym Protein Names
Fc-epsilon RI-alpha; FcERI; IgE Fc receptor subunit alpha
Protein Family
High affinity immunoglobulin epsilon receptor
UniProt Gene Name
FCER1A
UniProt Synonym Gene Names
FCE1A; FcERI
UniProt Entry Name
FCERA_HUMAN
NCBI Protein Information
high affinity immunoglobulin epsilon receptor subunit alpha

NCBI Summary for FCER1A

The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
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UniProt Comments for FCER1A

Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
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Research Articles on FCER1A

1. Patient stratification revealed a significant association (P < 0.05) of rs2427827 SNP with high IgE level Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP) patients. Nonetheless, we found no SNP associated with low serum IgE level patients. SNP (rs2427827) in the FcvarepsilonR1alpha gene region and high IgE levels may confer susceptibility to CRSwNP in north Indian population.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FCER1A antibody

 Reference Product  PubMed Publications
 MS4A2 antibody  >9 publications with FCER1A and MS4A2
 FCER1G antibody  >5 publications with FCER1A and FCER1G
 SYK antibody  >2 publications with FCER1A and SYK
 FYN antibody  >1 publications with FCER1A and FYN
 LYN antibody  >1 publications with FCER1A and LYN
 IGHE antibody  >1 publications with FCER1A and IGHE

Pathways associated with anti-FCER1A antibody

 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies  Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram

Diseases associated with anti-FCER1A antibody

 Disease Name  Pubmed Publications
 Asthma Antibodies  >23 publications with FCER1A and Asthma
 Respiratory Tract Diseases Antibodies  >19 publications with FCER1A and Respiratory Tract Diseases
 Respiratory Hypersensitivity Antibodies  >17 publications with FCER1A and Respiratory Hypersensitivity
 Urticaria Antibodies  >14 publications with FCER1A and Urticaria
 Drug Hypersensitivity Antibodies  >9 publications with FCER1A and Drug Hypersensitivity
 Inflammation Antibodies  >8 publications with FCER1A and Inflammation
 Rhinitis Antibodies  >6 publications with FCER1A and Rhinitis
 Angioedema Antibodies  >4 publications with FCER1A and Angioedema
 Necrosis Antibodies  >3 publications with FCER1A and Necrosis
 Carcinoma Antibodies  >2 publications with FCER1A and Carcinoma

Organs/Tissues associated with anti-FCER1A antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with FCER1A and Lung
 Bone Antibodies  >4 publications with FCER1A and Bone
 Bone Marrow Antibodies  >4 publications with FCER1A and Bone Marrow
 Brain Antibodies  >3 publications with FCER1A and Brain
 Kidney Antibodies  >1 publications with FCER1A and Kidney
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