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FCN3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6003157

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile… More details

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Product Overview

Online Datasheet in PDF
Product Name
FCN3, Polyclonal Antibody
Full Product Name
FCN3, CT (FCN3, FCNH, HAKA1, Ficolin-3, Collagen/fibrinogen domain-containing lectin 3 p35, Collagen/fibrinogen domain-containing protein 3, Hakata antigen)
Product Gene Name
anti-FCN3 antibody
Product Synonym Names
Anti -FCN3, CT (FCN3, FCNH, HAKA1, Ficolin-3, Collagen/fibrinogen domain-containing lectin 3 p35, Collagen/fibrinogen domain-containing protein 3, Hakata antigen)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human FCN3.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 1; NC_000001.10 (27695601..27701315, complement). Location: 1p36.11
OMIM
604973
3D Structure
ModBase 3D Structure for O75636
Grade
Affinity Purified
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 214-243 in the C-terminal region of human FCN3.

Product Categories/Family for anti-FCN3 antibody

Antibodies; Abs to Fibrinogen
Applications Tested/Suitable for anti-FCN3 antibody
ELISA, Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-FCN3 antibody
Recommended Dilution:
Western Blot: 1:1000
Immunohistochemistry (FFPE): 1:10-1:50
Flow Cytometry: 1:10-1:50

Other applications have not been tested. Optimal dilutions to be determined by the researcher.

Western Blot (WB) of anti-FCN3 antibody

Western Blot analysis of K562 cell line lysates (35ug/lane) using MBS6003157. This demonstrates the MBS6003157 detected the FCN3 protein (arrow).
Rabbit Anti-FCN3 Polyclonal Antibody – Cat# MBS6003157

Western Blot (WB) of anti-FCN3 antibody

Western Blot analysis of Jurkat whole cell lysate (20ug/lane) using MBS6003157 (1:500)
Secondary IgG (HRP) Goat Anti-Rabbit (1:10,000)
Predicted band size : 33kD
Rabbit Anti-FCN3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6003157

Immunohistochemistry (IHC) of anti-FCN3 antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue using MBS6003157 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS6003157 for immunohistochemistry.
Rabbit Anti-FCN3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6003157

Flow Cytometry (FC/FACS) of anti-FCN3 antibody

Flow Cytometric analysis of K562 cells using MBS6003157 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-FCN3 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6003157

Other Notes

Small volumes of anti-FCN3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FCN3 purchase

MBS6003157 is an antibody targeting FCN3. Also known as FCN3, CT (FCN3, FCNH, HAKA1, Ficolin-3, Collagen/fibrinogen domain-containing lectin 3 p35, Collagen/fibrinogen domain-containing protein 3, Hakata antigen). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FCN3. It may not necessarily be applicable to this product.

NCBI GI #
27754778
NCBI GeneID
8547
NCBI Accession #
NP_775628.1
UniProt Primary Accession #
O75636
UniProt Secondary Accession #
Q6IBJ5; Q8WW86
UniProt Related Accession #
O75636
GenBank Nucleotide #
NM_173452.1
NCBI Official Full Name
ficolin-3 isoform 2
NCBI Official Synonym Full Names
ficolin (collagen/fibrinogen domain containing) 3
NCBI Official Symbol
FCN3
NCBI Official Synonym Symbols
FCNH; HAKA1
UniProt Protein Name
Ficolin-3
UniProt Synonym Protein Names
Collagen/fibrinogen domain-containing lectin 3 p35; Collagen/fibrinogen domain-containing protein 3; Hakata antigen
Protein Family
Ficolin
UniProt Gene Name
FCN3
UniProt Synonym Gene Names
FCNH; HAKA1
UniProt Entry Name
FCN3_HUMAN
NCBI Protein Information
ficolin-3; H-ficolin; ficolin 3; collagen/fibrinogen domain-containing protein 3; collagen/fibrinogen domain-containing lectin 3 p35; ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

UniProt Comments for FCN3

FCN3: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D). FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine. Belongs to the ficolin lectin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: collagen; extracellular region

Molecular Function: protein binding; carbohydrate binding; antigen binding

Biological Process: negative regulation of virion penetration into host cell; innate immune response; complement activation, lectin pathway; recognition of apoptotic cell; defense response to virus; complement activation

Disease: Immunodeficiency Due To Ficolin 3 Deficiency
Show more

Research Articles on FCN3

1. Increased fucosylation of ficolin 3 in plasma of the rheumatoid arthritis patients

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FCN3 antibody

 Reference Product  PubMed Publications
 MASP2 antibody  >11 publications with FCN3 and MASP2
 MASP1 antibody  >8 publications with FCN3 and MASP1
 MBL2 antibody  >4 publications with FCN3 and MBL2
 C1R antibody  >1 publications with FCN3 and C1R
 C1S antibody  >1 publications with FCN3 and C1S

Pathways associated with anti-FCN3 antibody

 Products by Pathway  Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway antibodies  Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Lectin Pathway Of Complement Activation antibodies  Lectin Pathway Of Complement Activation Diagram

Diseases associated with anti-FCN3 antibody

 Disease Name  Pubmed Publications
 Immunologic Deficiency Syndromes Antibodies  >1 publications with FCN3 and Immunologic Deficiency Syndromes

Organs/Tissues associated with anti-FCN3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >29 publications with FCN3 and Blood
 Liver Antibodies  >5 publications with FCN3 and Liver
 Lung Antibodies  >4 publications with FCN3 and Lung
 Kidney Antibodies  >2 publications with FCN3 and Kidney
 Intestine Antibodies  >1 publications with FCN3 and Intestine
 Placenta Antibodies  >1 publications with FCN3 and Placenta
 Eye Antibodies  >1 publications with FCN3 and Eye
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