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FCRL3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6298735

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FCRL3, Polyclonal Antibody
Full Product Name
FCRL3, CT (FCRL3, FCRH3, IFGP3, IRTA3, SPAP2, Fc receptor-like protein 3, Fc receptor homolog 3, IFGP family protein 3, Immune receptor translocation-associated protein 3, SH2 domain-containing phosphatase anchor protein 2, CD307c) (PE)
Product Gene Name
anti-FCRL3 antibody
Product Synonym Names
FCRL3; FCRH3; IFGP3; IRTA3; SPAP2; Fc receptor-like protein 3; Fc receptor homolog 3; IFGP family protein 3; Immune receptor translocation-associated protein 3; SH2 domain-containing phosphatase anchor protein 2; CD307c
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
77,921 Da
OMIM
180300
3D Structure
ModBase 3D Structure for Q96P31
Immunogen
FCRL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 694-720 amino acids from the C-terminal region of human FCRL3.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-FCRL3 antibody

Antibodies; CD Markers
Applications Tested/Suitable for anti-FCRL3 antibody
Western Blot (WB), FLISA
Application Notes for anti-FCRL3 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-FCRL3 antibody

FCRL3 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the FCRL3 antibody detected the FCRL3 protein (arrow).
Rabbit Anti-FCRL3 Polyclonal Antibody – Cat# MBS6298735

Product References and Citations for anti-FCRL3 antibody

Wu, H., et al. Hum. Immunol. (2010). In press: Swainson, L.A., et al. J. Immunol. 184(7):3639-3647(2010). Davila, S., et al. Genes Immun. 11(3):232-238(2010). Zheng, R., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26(6):681-685(2009). Gibson, A.W., et al. Arthritis Rheum. 60(11):3510-3512(2009).

Other Notes

Small volumes of anti-FCRL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FCRL3 purchase

MBS6298735 is an antibody targeting FCRL3. Also known as FCRL3, CT (FCRL3, FCRH3, IFGP3, IRTA3, SPAP2, Fc receptor-like protein 3, Fc receptor homolog 3, IFGP family protein 3, Immune receptor translocation-associated protein 3, SH2 domain-containing phosphatase anchor protein 2, CD307c) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FCRL3. It may not necessarily be applicable to this product.

NCBI GI #
21314764
NCBI GeneID
115352
NCBI Accession #
NP_443171.2
UniProt Primary Accession #
Q96P31
UniProt Secondary Accession #
Q5VXZ8; Q8N6S2; Q96LA4; Q96P27; Q96P28; Q96P29; Q96P30; A0N0M4; A8MTH7; D3DVD2
UniProt Related Accession #
Q96P31
GenBank Nucleotide #
NM_052939.3
NCBI Official Full Name
Fc receptor-like protein 3
NCBI Official Synonym Full Names
Fc receptor-like 3
NCBI Official Symbol
FCRL3
NCBI Official Synonym Symbols
FCRH3; IFGP3; IRTA3; SPAP2; CD307c
UniProt Protein Name
Fc receptor-like protein 3
UniProt Synonym Protein Names
Fc receptor homolog 3; FcRH3; IFGP family protein 3; hIFGP3; Immune receptor translocation-associated protein 3; SH2 domain-containing phosphatase anchor protein 2; CD_antigen: CD307c
Protein Family
Fc receptor-like protein
UniProt Gene Name
FCRL3
UniProt Synonym Gene Names
FCRH3; IFGP3; IRTA3; SPAP2; FcR-like protein 3; FcRL3; FcRH3; hIFGP3
UniProt Entry Name
FCRL3_HUMAN
NCBI Protein Information
Fc receptor-like protein 3

UniProt Comments for FCRL3

FCRL3: Genetic variation in FCRL3 may be a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: integral to membrane; plasma membrane
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Research Articles on FCRL3

1. the TIGIT/FCRL3 combination allows reliable identification of Helios(+) Treg cells even in highly activated conditions in vitro as well as in PBMCs of autoimmune patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FCRL3 antibody

 Reference Product  PubMed Publications
 PTPN22 antibody  >24 publications with FCRL3 and PTPN22
 CTLA4 antibody  >15 publications with FCRL3 and CTLA4
 PADI4 antibody  >12 publications with FCRL3 and PADI4
 TSHR antibody  >8 publications with FCRL3 and TSHR
 ZAP70 antibody  >2 publications with FCRL3 and ZAP70
 SYK antibody  >1 publications with FCRL3 and SYK

Diseases associated with anti-FCRL3 antibody

 Disease Name  Pubmed Publications
 Graves Disease Antibodies  >17 publications with FCRL3 and Graves Disease
 Goiter Antibodies  >9 publications with FCRL3 and Goiter
 Thyroiditis, Autoimmune Antibodies  >8 publications with FCRL3 and Thyroiditis, Autoimmune
 Metabolic Diseases Antibodies  >8 publications with FCRL3 and Metabolic Diseases
 Inflammation Antibodies  >6 publications with FCRL3 and Inflammation
 Demyelinating Diseases Antibodies  >4 publications with FCRL3 and Demyelinating Diseases
 Cardiovascular Diseases Antibodies  >3 publications with FCRL3 and Cardiovascular Diseases
 Necrosis Antibodies  >2 publications with FCRL3 and Necrosis
 Memory Disorders Antibodies  >1 publications with FCRL3 and Memory Disorders
 Neoplasm Metastasis Antibodies  >1 publications with FCRL3 and Neoplasm Metastasis

Organs/Tissues associated with anti-FCRL3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >25 publications with FCRL3 and Blood
 Bone Marrow Antibodies  >2 publications with FCRL3 and Bone Marrow
 Liver Antibodies  >2 publications with FCRL3 and Liver
 Eye Antibodies  >1 publications with FCRL3 and Eye
 Pharynx Antibodies  >1 publications with FCRL3 and Pharynx
 Brain Antibodies  >1 publications with FCRL3 and Brain
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