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FLCN Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6476735

MBS6476735 is an antibody targeting FLCN. Also known as FLCN, CT (Folliculin, Birt-Hogg-Dube Syndrome Protein, BHD Skin Lesion Fibrofolliculoma Protein, BHD) (Azide free) (HRP). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FLCN, Polyclonal Antibody
Full Product Name
FLCN, CT (Folliculin, Birt-Hogg-Dube Syndrome Protein, BHD Skin Lesion Fibrofolliculoma Protein, BHD) (Azide free) (HRP)
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Immunoaffinity chromatography.
Specificity
Recognizes human FLCN.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
64,473 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (17115523..17140502, complement). Location: 17p11.2
OMIM
AF517523 mRNA
3D Structure
ModBase 3D Structure for Q8NFG4
Immunogen
Synthetic peptide selected from the C-terminal region of human FLCN (KLH).
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-FLCN antibody

Applications Tested/Suitable for anti-FLCN antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-FLCN antibody
WB: 1:100-1:500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-FLCN antibody

Western blot analysis MBS623543 pre-incubated without (lane 1) and with(lane 2) blocking peptide in K562 cell line lysate. FLCN (arrow) was detected using the purified Pab.
Rabbit Anti-FLCN Polyclonal Antibody – Cat# MBS6476735

Immunohistochemistry (IHC) of anti-FLCN antibody

F5730-01 immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.
Rabbit Anti-FLCN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6476735

Product References and Citations for anti-FLCN antibody

1. Khoo, S.K., et.al., J. Med. Genet. 39(12), 906-912 (2002). 2. Shin, J.H., et.al., J. Med. Genet. 40(5), 364-367 (2003).

Other Notes

Small volumes of anti-FLCN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FLCN. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
folliculin isoform 1
NCBI Official Synonym Full Names
folliculin
NCBI Official Symbol
FLCN
NCBI Official Synonym Symbols
BHD; FLCL
UniProt Protein Name
Folliculin
UniProt Synonym Protein Names
BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein
Protein Family
UniProt Gene Name
FLCN
UniProt Synonym Gene Names
BHD
NCBI Protein Information
folliculin; birt-Hogg-Dube syndrome protein; BHD skin lesion fibrofolliculoma protein

NCBI Summary for FLCN

This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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UniProt Comments for FLCN

May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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