FLII Antibody – Rabbit Polyclonal

FLI: May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration. Deletion of the FLII gene may be a cause of Smith-Magenis syndrome (SMS). It is a contiguous gene deletion syndrome involving developmental abnormalities and mental retardation. The spectrum of clinical findings includes short stature, brachydactyly, developmental delay, dysmorphic features, sleep disturbances, and behavioral problems.

Protein type: Nuclear receptor co-regulator; Actin-binding

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: nucleoplasm; focal adhesion; cytoplasm; microtubule organizing center

Molecular Function: protein binding; actin binding

Biological Process: actin filament severing; muscle contraction; transcription, DNA-dependent; regulation of transcription, DNA-dependent; multicellular organismal development; actin cytoskeleton organization and biogenesis

Disease: Smith-magenis Syndrome