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FNTA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904465

Farnesyl-protein transferase alpha-subunit (FNTA) catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal… More details

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Product Overview

Online Datasheet in PDF
Product Name
FNTA, Polyclonal Antibody
Full Product Name
Rabbit anti-FNTA Antibody, Affinity Purified
Product Gene Name
anti-FNTA antibody
Product Synonym Names
GGTase-I-alpha; protein prenyltransferase alpha subunit repeat containing 2; Type I protein geranyl-geranyltransferase subunit alpha; type I protein geranyl-geranyltransferase alpha subunit; ras proteins prenyltransferase subunit alpha; PTAR2; CAAX farnesyltransferase subunit alpha; PGGT1A; protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; FTase-alpha; FPTA; farnesyl-protein transferase alpha-subunit; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; farnesyltransferase, CAAX box, alpha
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
36,493 Da
OMIM
134635
3D Structure
ModBase 3D Structure for P49354
Immunogen
Between 329 and C-terminus
Conjugation
Unconjugated

Product Categories/Family for anti-FNTA antibody

Primary Antibodies
Applications Tested/Suitable for anti-FNTA antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-FNTA antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate
IHC: 1:500-1:2000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Immunohistochemistry (IHC) of anti-FNTA antibody

Detection of human FNTA by immunohistochemistry. Sample: FFPE section of human testicular seminoma. Antibody: Affinity purified rabbit anti-FNTA (Cat. No. MBS3904465 Lot1) used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
Rabbit Anti-FNTA Polyclonal Antibody – Cat# MBS3904465

Immunoprecipitation (IP) of anti-FNTA antibody

Detection of human FNTA by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-FNTA antibody MBS3904465 (lot MBS3904465-1) used for IP at 6 ug per reaction. FNTA was also immunoprecipitated by rabbit anti-FNTA antibody BL15722. For blotting immunoprecipitated FNTA, MBS3904465 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-FNTA Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS3904465

Western Blot (WB) of anti-FNTA antibody

Detection of human FNTA by western blot. Samples: Whole cell lysate (50 ug) from HeLa, HEK293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-FNTA antibody MBS3904465 (lot MBS3904465-1) used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Rabbit Anti-FNTA Polyclonal Antibody, Western Blot (WB) – Cat# MBS3904465

Other Notes

Small volumes of anti-FNTA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FNTA purchase

MBS3904465 is an antibody targeting FNTA. Also known as Rabbit anti-FNTA Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FNTA. It may not necessarily be applicable to this product.

NCBI GI #
4503771
NCBI GeneID
2339
NCBI Accession #
NP_002018.1
UniProt Primary Accession #
P49354
UniProt Secondary Accession #
Q53XJ9; Q9UDC1; A6NJW0
UniProt Related Accession #
P49354; AAB26814
GenBank Nucleotide #
NM_002027.2
NCBI Official Full Name
protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
NCBI Official Synonym Full Names
farnesyltransferase, CAAX box, alpha
NCBI Official Symbol
FNTA
NCBI Official Synonym Symbols
FPTA; PTAR2; PGGT1A
UniProt Protein Name
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
UniProt Synonym Protein Names
CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha; GGTase-I-alpha
Protein Family
Protein farnesyltransferase/geranylgeranyltransferase
UniProt Gene Name
FNTA
UniProt Synonym Gene Names
GGTase-I-alpha
UniProt Entry Name
FNTA_HUMAN
NCBI Protein Information
protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; FTase-alpha; GGTase-I-alpha; farnesyl-protein transferase alpha-subunit; ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase alpha subunit; pro

NCBI Summary for FNTA

Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]
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UniProt Comments for FNTA

FNTA: Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK. Belongs to the protein prenyltransferase subunit alpha family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.5.1.59; EC 2.5.1.58

Chromosomal Location of Human Ortholog: 8p11

Cellular Component: microtubule associated complex; cytoplasm; cytosol

Molecular Function: protein binding; protein geranylgeranyltransferase activity; microtubule binding; CAAX-protein geranylgeranyltransferase activity; acetylcholine receptor regulator activity; receptor tyrosine kinase binding; alpha-tubulin binding; protein farnesyltransferase activity; Rab-protein geranylgeranyltransferase activity

Biological Process: protein geranylgeranylation; rhodopsin mediated signaling; phototransduction, visible light; protein farnesylation; regulation of rhodopsin mediated signaling; apoptosis; neurotransmitter receptor metabolic process; transforming growth factor beta receptor signaling pathway; regulation of receptor activity; cell structure disassembly during apoptosis
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Research Articles on FNTA

1. our findings identify Geranylgeranyl transferase 1 as a key regulator of human airway smooth muscle cell viability

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FNTA antibody

 Reference Product  PubMed Publications
 FNTB antibody  >4 publications with FNTA and FNTB
 KRAS antibody  >1 publications with FNTA and KRAS

Pathways associated with anti-FNTA antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway antibodies  Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway Diagram
 Programmed Cell Death Pathway antibodies  Programmed Cell Death Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 Terpenoid Backbone Biosynthesis Pathway antibodies  Terpenoid Backbone Biosynthesis Pathway Diagram

Diseases associated with anti-FNTA antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with FNTA and Disease Models, Animal
 Breast Neoplasms Antibodies  >1 publications with FNTA and Breast Neoplasms
 Immune System Diseases Antibodies  >1 publications with FNTA and Immune System Diseases
 Hypertrophy Antibodies  >1 publications with FNTA and Hypertrophy
 Liver Neoplasms Antibodies  >1 publications with FNTA and Liver Neoplasms
 Nervous System Diseases Antibodies  >1 publications with FNTA and Nervous System Diseases
 Hemorrhage Antibodies  >1 publications with FNTA and Hemorrhage
 Heart Diseases Antibodies  >1 publications with FNTA and Heart Diseases
 Cognition Disorders Antibodies  >1 publications with FNTA and Cognition Disorders
 Weight Loss Antibodies  >1 publications with FNTA and Weight Loss

Organs/Tissues associated with anti-FNTA antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with FNTA and Liver
 Heart Antibodies  >2 publications with FNTA and Heart
 Connective Tissue Antibodies  >2 publications with FNTA and Connective Tissue
 Blood Antibodies  >2 publications with FNTA and Blood
 Adipose Tissue Antibodies  >2 publications with FNTA and Adipose Tissue
 Lung Antibodies  >2 publications with FNTA and Lung
 Brain Antibodies  >2 publications with FNTA and Brain
 Thyroid Antibodies  >1 publications with FNTA and Thyroid
 Stomach Antibodies  >1 publications with FNTA and Stomach
 Skin Antibodies  >1 publications with FNTA and Skin
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