• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

FOLH1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6299587

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide… More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FOLH1, Polyclonal Antibody
Full Product Name
FOLH1, NT (FOLH1, FOLH, NAALAD1, PSM, PSMA, Glutamate carboxypeptidase 2, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, N-acetyla
Product Gene Name
anti-FOLH1 antibody
Product Synonym Names
FOLH1; FOLH; NAALAD1; PSM; PSMA; Glutamate carboxypeptidase 2; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; Glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; N-acetylated-alpha-linked acidic dipeptidase I; Prostate-specific membrane antigen; Pteroylpoly-gamma-glutamate carboxypeptidase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
600934
3D Structure
ModBase 3D Structure for Q04609
Immunogen
FOLH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-190 amino acids from the N-terminal region of human FOLH1.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-FOLH1 antibody

Antibodies; Enzymes; Carboxypeptidase
Applications Tested/Suitable for anti-FOLH1 antibody
Immunofluorescence (IF), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-FOLH1 antibody
IF: 1:10-50
FLISA: 1:1,000
IHC: 1:10-50
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-FOLH1 antibody

FOLH1 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the FOLH1 antibody detected the FOLH1 protein (arrow).
Rabbit Anti-FOLH1 Polyclonal Antibody – Cat# MBS6299587

Immunohistochemistry (IHC) of anti-FOLH1 antibody

FOLH1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FOLH1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-FOLH1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6299587

Immunofluorescence (IF) of anti-FOLH1 antibody

Confocal immunofluorescent analysis of FOLH1 Antibody (N-term) with ZR-75-1 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-FOLH1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6299587

Product References and Citations for anti-FOLH1 antibody

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Giusti, B., et al. Thromb. Haemost. 104(2):231-242(2010). Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010): Mlcochova, P., et al. Prostate 69(5):471-479(2009). Davis, M.I., et al. Proc. Natl. Acad. Sci. U.S.A. 102(17):5981-5986(2005).

Other Notes

Small volumes of anti-FOLH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOLH1 purchase

MBS6299587 is an antibody targeting FOLH1. Also known as FOLH1, NT (FOLH1, FOLH, NAALAD1, PSM, PSMA, Glutamate carboxypeptidase 2, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, N-acetyla. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FOLH1. It may not necessarily be applicable to this product.

NCBI GI #
301500668
NCBI GeneID
2346
NCBI Accession #
NP_001180400.1
NCBI Related Accession #
NP_001014986.1
UniProt Primary Accession #
Q04609
UniProt Related Accession #
Q04609
GenBank Nucleotide #
NP_001180400.1
NCBI Official Full Name
glutamate carboxypeptidase 2 isoform 3
NCBI Official Synonym Full Names
folate hydrolase 1
NCBI Official Symbol
FOLH1
NCBI Official Synonym Symbols
PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase
UniProt Protein Name
Glutamate carboxypeptidase 2
UniProt Synonym Protein Names
Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; FGCP; Glutamate carboxypeptidase II; GCPII; Membrane glutamate carboxypeptidase; mGCP; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; Prostate-specific membrane antigen; PSM; PSMA; Pteroylpoly-gamma-glutamate carboxypeptidase
Protein Family
Glutamate carboxypeptidase
UniProt Gene Name
FOLH1
UniProt Synonym Gene Names
FOLH; NAALAD1; PSM; PSMA; FGCP; GCPII; mGCP; NAALADase I; PSM; PSMA
UniProt Entry Name
FOLH1_HUMAN
NCBI Protein Information
glutamate carboxypeptidase 2

NCBI Summary for FOLH1

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
Show more

UniProt Comments for FOLH1

FOLH1: Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Belongs to the peptidase M28 family. M28B subfamily. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 3.4.17.21; Protease

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: membrane; integral to plasma membrane; cytoplasm

Molecular Function: peptidase activity; dipeptidase activity; metallopeptidase activity; carboxypeptidase activity; metal ion binding

Biological Process: folic acid and derivative metabolic process; proteolysis
Show more

Research Articles on FOLH1

1. Medullary thyroid cancer patients with a higher number of PSMA-positive microvessels showed favorable prognosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-FOLH1 antibody

 Products by Pathway  Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram

Diseases associated with anti-FOLH1 antibody

 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >11 publications with FOLH1 and Prostatic Neoplasms
 Brain Diseases Antibodies  >3 publications with FOLH1 and Brain Diseases
 Lung Neoplasms Antibodies  >3 publications with FOLH1 and Lung Neoplasms
 Nervous System Diseases Antibodies  >2 publications with FOLH1 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >2 publications with FOLH1 and Congenital Abnormalities
 Necrosis Antibodies  >2 publications with FOLH1 and Necrosis
 Nerve Degeneration Antibodies  >1 publications with FOLH1 and Nerve Degeneration
 Hypertension Antibodies  >1 publications with FOLH1 and Hypertension
 Hyperplasia Antibodies  >1 publications with FOLH1 and Hyperplasia
 Breast Neoplasms Antibodies  >1 publications with FOLH1 and Breast Neoplasms

Organs/Tissues associated with anti-FOLH1 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >17 publications with FOLH1 and Prostate
 Brain Antibodies  >8 publications with FOLH1 and Brain
 Kidney Antibodies  >4 publications with FOLH1 and Kidney
 Bone Antibodies  >2 publications with FOLH1 and Bone
 Intestine Antibodies  >2 publications with FOLH1 and Intestine
 Nerve Antibodies  >2 publications with FOLH1 and Nerve
 Muscle Antibodies  >1 publications with FOLH1 and Muscle
 Liver Antibodies  >1 publications with FOLH1 and Liver
 Salivary Gland Antibodies  >1 publications with FOLH1 and Salivary Gland
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000