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FOLR3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9212979

This gene encodes a member of the folate receptor (FOLR)family, members of which have a high affinity for folic acid andfor several reduced folic acid derivatives, and mediate delivery of5-methyltetrahydrofolate to the interior of cells. This geneincludes two… More details

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Product Overview

Online Datasheet in PDF
Product Name
FOLR3, Polyclonal Antibody
Full Product Name
FOLR3 Antibody (N-term)
Product Gene Name
Product Synonym Names
Folate receptor gamma; FR-gamma; Folate receptor 3; FOLR3
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.33 (lot specific)
Specificity
This FOLR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human FOLR3.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
FOLR3 peptide (MBS9220053) is used for blocking the activity of FOLR3 antibody (MBS9212979)
Molecular Weight
27638
Immunogen Sequence Positions
24-53
OMIM
602469
3D Structure
ModBase 3D Structure for P41439
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Applications Tested/Suitable for anti-FOLR3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-FOLR3 antibody
WB~~1:1000

Western Blot (WB) of anti-FOLR3 antibody

FOLR3 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the FOLR3 antibody detected the FOLR3 protein (arrow).
Rabbit Anti-FOLR3 Polyclonal Antibody – Cat# MBS9212979

Product References and Citations for anti-FOLR3 antibody

O'Byrne, M.R., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(8):689-694(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Boyles, A.L., et al. Genet. Epidemiol. 33(3):247-255(2009)
Franke, B., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 85(3):216-226(2009)
Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :

Other Notes

Small volumes of anti-FOLR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOLR3 purchase

MBS9212979 is an antibody targeting FOLR3. Also known as FOLR3 Antibody (N-term). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FOLR3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
folate receptor gamma
NCBI Official Synonym Full Names
folate receptor 3 (gamma)
NCBI Official Symbol
FOLR3
NCBI Official Synonym Symbols
FR-G; FR-gamma; gamma-hFR
UniProt Protein Name
Folate receptor gamma
UniProt Synonym Protein Names
Folate receptor 3
Protein Family
UniProt Gene Name
FOLR3
UniProt Synonym Gene Names
FR-gamma
UniProt Entry Name
FOLR3_HUMAN
NCBI Protein Information
folate receptor gamma

NCBI Summary for FOLR3

This gene encodes a member of the folate receptor (FOLR) family, members of which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene includes two polymorphic variants; the shorter one has two base deletion in the CDS, resulting in a truncated polypeptide, compared to the longer one. Both protein products are constitutively secreted in hematopoietic tissues and are potential serum marker for certain hematopoietic malignancies. The longer protein has a 71% and 79% sequence homology with the FOLR1 and FOLR2 proteins, respectively. [provided by RefSeq, Jul 2008]
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UniProt Comments for FOLR3

FOLR3: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate. Belongs to the folate receptor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: extrinsic to membrane; membrane; extracellular region

Molecular Function: folic acid binding

Biological Process: folic acid transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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