FOXE1 Antibody – Goat Polyclonal

This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. [provided by RefSeq, Jul 2008]

FOXE1: Probable transcription factor. Could be involved in thyroid gland organogenesis. Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome (BLS). BLS is associated with thyroid agenesis, cleft palate and choanal atresia.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: nucleus

Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: anatomical structure morphogenesis; cell migration; embryonic organ morphogenesis; hair follicle morphogenesis; hard palate development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; soft palate development; thymus development; thyroid gland development; thyroid hormone generation; transcription, DNA-dependent

Disease: Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate; Thyroid Cancer, Nonmedullary, 4