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FOXN3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6299909

This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
FOXN3, Polyclonal Antibody
Full Product Name
FOXN3, CT (FOXN3, C14orf116, CHES1, Forkhead box protein N3, Checkpoint suppressor 1) (Azide free) (HRP)
Product Gene Name
anti-FOXN3 antibody
Product Synonym Names
FOXN3; C14orf116; CHES1; Forkhead box protein N3; Checkpoint suppressor 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
51,534 Da
OMIM
602628
3D Structure
ModBase 3D Structure for O00409
Immunogen
FOXN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 379-408 amino acids from the C-terminal region of human FOXN3.
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-FOXN3 antibody

Antibodies; Transcription Factors
Applications Tested/Suitable for anti-FOXN3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-FOXN3 antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Immunofluorescence (IF) of anti-FOXN3 antibody

Fluorescent image of Hela cell stained with FOXN3 Antibody (C-term).Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with FOXN3 primary antibody (1:25, 1 h at 37 degree C). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37 degree C).Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37 degree C).FOXN3 immunoreactivity is localized to Nucleus significantly.
Rabbit Anti-FOXN3 Polyclonal Antibody – Cat# MBS6299909

Western Blot (WB) of anti-FOXN3 antibody

FOXN3 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the FOXN3 antibody detected the FOXN3 protein (arrow).
Rabbit Anti-FOXN3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6299909

Product References and Citations for anti-FOXN3 antibody

Samaan, G., et al. Biochem. Biophys. Res. Commun. 400(1):60-65(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010): Markowski, J., et al. Eur Arch Otorhinolaryngol 266(10):1501-1507(2009). Schlade-Bartusiak, K., et al. Am. J. Med. Genet. A 146A (1), 117-123 (2008).

Other Notes

Small volumes of anti-FOXN3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOXN3 purchase

MBS6299909 is an antibody targeting FOXN3. Also known as FOXN3, CT (FOXN3, C14orf116, CHES1, Forkhead box protein N3, Checkpoint suppressor 1) (Azide free) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FOXN3. It may not necessarily be applicable to this product.

NCBI GI #
146231981
NCBI GeneID
1112
NCBI Accession #
NP_005188.2
UniProt Primary Accession #
O00409
UniProt Secondary Accession #
Q96II7; Q9UIE7
UniProt Related Accession #
O00409
GenBank Nucleotide #
NM_005197
NCBI Official Full Name
Homo sapiens forkhead box N3 (FOXN3), transcript variant 2, mRNA
NCBI Official Synonym Full Names
forkhead box N3
NCBI Official Symbol
FOXN3
NCBI Official Synonym Symbols
CHES1; PRO1635; C14orf116
UniProt Protein Name
Forkhead box protein N3
UniProt Synonym Protein Names
Checkpoint suppressor 1
Protein Family
Forkhead box protein
UniProt Gene Name
FOXN3
UniProt Synonym Gene Names
C14orf116; CHES1
UniProt Entry Name
FOXN3_HUMAN
NCBI Protein Information
forkhead box protein N3; checkpoint suppressor 1

NCBI Summary for FOXN3

This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
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Research Articles on FOXN3

1. MEN1 patients with MEN1 mutations leading to CHES1-loss of interaction have a higher risk of malignant pancreatic neuroendocrine tumors with an aggressive course of disease and disease-related death.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FOXN3 antibody

 Reference Product  PubMed Publications
 MEN1 antibody  >3 publications with FOXN3 and MEN1
 SNW1 antibody  >1 publications with FOXN3 and SNW1

Diseases associated with anti-FOXN3 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >4 publications with FOXN3 and Carcinoma
 Lung Diseases Antibodies  >2 publications with FOXN3 and Lung Diseases
 Lung Neoplasms Antibodies  >2 publications with FOXN3 and Lung Neoplasms
 Liver Diseases Antibodies  >2 publications with FOXN3 and Liver Diseases
 Adenocarcinoma Antibodies  >1 publications with FOXN3 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >1 publications with FOXN3 and Carcinoma, Hepatocellular
 Anemia Antibodies  >1 publications with FOXN3 and Anemia
 Breast Neoplasms Antibodies  >1 publications with FOXN3 and Breast Neoplasms
 Atherosclerosis Antibodies  >1 publications with FOXN3 and Atherosclerosis
 Liver Neoplasms Antibodies  >1 publications with FOXN3 and Liver Neoplasms

Organs/Tissues associated with anti-FOXN3 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with FOXN3 and Liver
 Embryonic Tissue Antibodies  >3 publications with FOXN3 and Embryonic Tissue
 Blood Antibodies  >3 publications with FOXN3 and Blood
 Eye Antibodies  >3 publications with FOXN3 and Eye
 Connective Tissue Antibodies  >2 publications with FOXN3 and Connective Tissue
 Muscle Antibodies  >2 publications with FOXN3 and Muscle
 Bone Antibodies  >2 publications with FOXN3 and Bone
 Mouth Antibodies  >2 publications with FOXN3 and Mouth
 Lung Antibodies  >2 publications with FOXN3 and Lung
 Uterus Antibodies  >1 publications with FOXN3 and Uterus
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