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FOXO3A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6477073

MBS6477073 is an antibody targeting FOXO3A. Also known as FOXO3A (Forkhead box O3, AF6q21, AF6q21 protein, DKFZp781A0677, FKHRL1, FKHRL1P2, Forkhead box protein O3, Forkhead in rhabdomyosarcoma-like 1, FOXO2, MGC12739, MGC31925) (AP). Reactive in Human. Host:… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
FOXO3A, Polyclonal Antibody
Full Product Name
FOXO3A (Forkhead box O3, AF6q21, AF6q21 protein, DKFZp781A0677, FKHRL1, FKHRL1P2, Forkhead box protein O3, Forkhead in rhabdomyosarcoma-like 1, FOXO2, MGC12739, MGC31925) (AP)
Product Gene Name
anti-FOXO3A antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.
Purity/Purification
Purified by affinity chromatography.
Specificity
Recognizes human FOX03A.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
48,406 Da
OMIM
602681
3D Structure
ModBase 3D Structure for O43524
Immunogen
Synthetic peptide corresponding to FOX03A. Cellular Localization: Cytoplasm › cytosol. Nucleus. Species sequence homology: mouse.
Conjugate
AP
Positive Control
FOXO3A in Jurkat cell lysate.
Note
Preservative Free

Product Categories/Family for anti-FOXO3A antibody

Antibodies; Transcription Factors
Applications Tested/Suitable for anti-FOXO3A antibody
Immunocytochemistry (ICC), Western Blot (WB)
Application Notes for anti-FOXO3A antibody
ICC: 1:500
WB: 1:500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-FOXO3A antibody

Western Blot Analysis: Representative lot data. Jurkat lysate was resolved by electrophoresis, transferred to PVDF membrane, and probed with anti-FOXO3A (1:500 dilution). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates protein FOXO3A (~migrate at 80kD).
Rabbit Anti-FOXO3A Polyclonal Antibody – Cat# MBS6477073

Immunocytochemistry (ICC) of anti-FOXO3A antibody

Immunocytochemistry: Representative lot data. Confocal fluorescent analysis of HeLa cells using anti-FOXO3A antibody (Red). Actin filaments have been labeled with Alexa Fluor 488-Phalloidin (Green). Nuclei are stained with DAPI (Blue). Antibody shows positive nuclear staining.
Rabbit Anti-FOXO3A Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS6477073

Other Notes

Small volumes of anti-FOXO3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FOXO3A. It may not necessarily be applicable to this product.

NCBI GI #
4503739
NCBI GeneID
2309
NCBI Accession #
NP_001446
UniProt Primary Accession #
O43524
UniProt Secondary Accession #
O15171; Q5T2I7; Q9BZ04; B4DVZ6; E1P5E6
UniProt Related Accession #
O43524
GenBank Nucleotide #
NM_001455
NCBI Official Full Name
forkhead box protein O3
NCBI Official Synonym Full Names
forkhead box O3
NCBI Official Symbol
FOXO3
NCBI Official Synonym Symbols
FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
UniProt Protein Name
Forkhead box protein O3
UniProt Synonym Protein Names
AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1
UniProt Gene Name
FOXO3
UniProt Synonym Gene Names
FKHRL1; FOXO3A
UniProt Entry Name
FOXO3_HUMAN
NCBI Protein Information
forkhead box protein O3; forkhead box O3A; forkhead homolog (rhabdomyosarcoma) like 1; forkhead in rhabdomyosarcoma-like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1

UniProt Comments for FOXO3A

FOXO3A: a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia.

Protein type: Oncoprotein; Autophagy; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; DNA binding; chromatin DNA binding; sequence-specific DNA binding; transcription factor activity; protein kinase binding

Biological Process: epidermal growth factor receptor signaling pathway; transcription from RNA polymerase II promoter; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; DNA damage response, signal transduction by p53 class mediator; initiation of primordial ovarian follicle growth; antral ovarian follicle growth; positive regulation of transcription, DNA-dependent; positive regulation of erythrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; ovulation from ovarian follicle; glucose homeostasis; oocyte maturation; regulation of translation; regulation of transcription from RNA polymerase II promoter; positive regulation of neuron apoptosis; innate immune response; positive regulation of transcription from RNA polymerase II promoter
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FOXO3A antibody

 Reference Product  PubMed Publications
 AKT1 antibody  >51 publications with FOXO3A and AKT1
 CDKN1B antibody  >49 publications with FOXO3A and CDKN1B
 SIRT1 antibody  >48 publications with FOXO3A and SIRT1
 CDKN1A antibody  >21 publications with FOXO3A and CDKN1A
 IKBKB antibody  >17 publications with FOXO3A and IKBKB
 CTNNB1 antibody  >16 publications with FOXO3A and CTNNB1
 SGK1 antibody  >7 publications with FOXO3A and SGK1
 SMAD3 antibody  >6 publications with FOXO3A and SMAD3
 TP53 antibody  >6 publications with FOXO3A and TP53
 SMAD2 antibody  >5 publications with FOXO3A and SMAD2

Pathways associated with anti-FOXO3A antibody

 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Nucleus Pathway antibodies  AKT Phosphorylates Targets In The Nucleus Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 Class I PI3K Signaling Events Mediated By Akt Pathway antibodies  Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram

Diseases associated with anti-FOXO3A antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >242 publications with FOXO3A and Neoplasms
 Carcinoma Antibodies  >71 publications with FOXO3A and Carcinoma
 Breast Neoplasms Antibodies  >48 publications with FOXO3A and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >46 publications with FOXO3A and Cardiovascular Diseases
 Necrosis Antibodies  >38 publications with FOXO3A and Necrosis
 Inflammation Antibodies  >38 publications with FOXO3A and Inflammation
 Heart Diseases Antibodies  >27 publications with FOXO3A and Heart Diseases
 Adenocarcinoma Antibodies  >26 publications with FOXO3A and Adenocarcinoma
 Hypertrophy Antibodies  >24 publications with FOXO3A and Hypertrophy
 Cell Transformation, Neoplastic Antibodies  >21 publications with FOXO3A and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-FOXO3A antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >142 publications with FOXO3A and Blood
 Muscle Antibodies  >141 publications with FOXO3A and Muscle
 Brain Antibodies  >56 publications with FOXO3A and Brain
 Vascular Antibodies  >51 publications with FOXO3A and Vascular
 Heart Antibodies  >50 publications with FOXO3A and Heart
 Lung Antibodies  >37 publications with FOXO3A and Lung
 Liver Antibodies  >36 publications with FOXO3A and Liver
 Bone Antibodies  >33 publications with FOXO3A and Bone
 Ovary Antibodies  >30 publications with FOXO3A and Ovary
 Nerve Antibodies  >26 publications with FOXO3A and Nerve
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