Rabbit Anti-FRMD3 Polyclonal Antibody – Cat# MBS6300139

FRMD3 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the FRMD3 antibody detected the FRMD3 protein (arrow).

FRMD3 Antibody – Rabbit Polyclonal

Name: FRMD3 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6300139
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6300139

Protein 4.1 of red blood cells, or 4.1R (EPB41; MIM 130500), is a multifunctional protein essential for maintaining erythrocyte shape and membrane mechanical properties. The protein 4.1 family comprises a group of structural proteins that includes, in… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FRMD3, Polyclonal Antibody

Full Product Name

FRMD3, ID (FRMD3, EPB41L4O, FERM domain-containing protein 3, Band 4.1-like protein 4O, Ovary type protein 4.1) (FITC)

Product Gene Name

anti-FRMD3 antibody

Product Synonym Names

FRMD3; EPB41L4O; FERM domain-containing protein 3; Band 4.1-like protein 4O; Ovary type protein 4.1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

OMIM

607619

3D Structure

ModBase 3D Structure for A2A2Y4

Immunogen

FRMD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-279 amino acids from the Central region of human FRMD3.

Conjugate

FITC

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-FRMD3 antibody

Antibodies; Proteins

Applications Tested/Suitable for anti-FRMD3 antibody

Western Blot (WB), FLISA

Application Notes for anti-FRMD3 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-FRMD3 antibody

Maeda, S., et al. Diabetes (2010). In press: Rose, J. Phd, et al. Mol. Med. (2010). In press: Pezzolesi, M.G., et al. Diabetes 58(6):1403-1410(2009). Haase, D., et al. Oncogene 26(30):4464-4468(2007). Ni, X., et al. J. Hum. Genet. 48(2):101-106(2003).

Other Notes

Small volumes of anti-FRMD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FRMD3 purchase

MBS6300139 is an antibody targeting FRMD3. Also known as FRMD3, ID (FRMD3, EPB41L4O, FERM domain-containing protein 3, Band 4.1-like protein 4O, Ovary type protein 4.1) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FRMD3. It may not necessarily be applicable to this product.

NCBI GI #

117500790

NCBI GeneID

257019

NCBI Accession #

NP_777598.3

UniProt Primary Accession #

A2A2Y4

UniProt Related Accession #

A2A2Y4

GenBank Nucleotide #

NP_777598.3

NCBI Official Full Name

FERM domain-containing protein 3 isoform 1

NCBI Official Synonym Full Names

FERM domain containing 3

NCBI Official Symbol

FRMD3

NCBI Official Synonym Symbols

4.1O; P410; EPB41LO; EPB41L4O

UniProt Protein Name

FERM domain-containing protein 3

UniProt Synonym Protein Names

Band 4.1-like protein 4O; Ovary type protein 4.1

Protein Family

FERM domain-containing protein

UniProt Gene Name

FRMD3

UniProt Synonym Gene Names

EPB41L4O; 4.1O

UniProt Entry Name

FRMD3_HUMAN

NCBI Protein Information

FERM domain-containing protein 3

NCBI Summary for FRMD3

The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

UniProt Comments for FRMD3

Function: Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. Ref.8

Subcellular location: Membrane; Single-pass membrane protein

Potential.

Tissue specificity: Ovary-specific. Ref.1

Developmental stage: Expressed in skeletal muscle, lower levels in thymus and brain. Ref.1

Sequence similarities: Contains 1 FERM domain.

Sequence caution: The sequence BAC04321.1 differs from that shown. Reason: Erroneous initiation. The sequence EAW62650.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on FRMD3

1. The risk (G and C) and non-risk (C and T) allele frequencies of the SNPs at the rs1888747 and rs739401 loci of FRMD3 and CARS, respectively, did not differ significantly between the diabetics with (case) and without (control) nephropathy (P > 0.05).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.