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FTH1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6475868

MBS6475868 is an antibody targeting FTH1. Also known as FTH1, CT (Ferritin Heavy Chain, Ferritin H Subunit, Cell Proliferation-inducing Gene 15 Protein, PIG15, OK/SW-cl.84, FTHL6, FTH) (Azide free) (HRP). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FTH1, Polyclonal Antibody
Full Product Name
FTH1, CT (Ferritin Heavy Chain, Ferritin H Subunit, Cell Proliferation-inducing Gene 15 Protein, PIG15, OK/SW-cl.84, FTHL6, FTH) (Azide free) (HRP)
Product Gene Name
anti-FTH1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Immunoaffinity chromatography.
Specificity
Recognizes human FTH1.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
21,226 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (61731757..61735132, complement). Location: 11q13
OMIM
134770
3D Structure
ModBase 3D Structure for P02794
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids aa154-183 in the C-terminal region of human FTH1, UniProt Accession #NP_002023.2, P02794
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-FTH1 antibody

Antibodies; Serum Proteins
Applications Tested/Suitable for anti-FTH1 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-FTH1 antibody
IHC: 1:50-1:100
ELISA: 1:1,000
WB: 1:100-1:500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-FTH1 antibody

Western Blot analysis of A2058 cell line lysates (35ug/lane) usingMBS629951. FTH1 (arrow) was detected using theMBS629951.
Rabbit Anti-FTH1 Polyclonal Antibody – Cat# MBS6475868

Immunohistochemistry (IHC) of anti-FTH1 antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma usingMBS629951, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry.
Rabbit Anti-FTH1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6475868

Product References and Citations for anti-FTH1 antibody

1. Almeida, R.S., et.al., PLoS Pathog. 4(11), E1000217 (2008).

Other Notes

Small volumes of anti-FTH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FTH1. It may not necessarily be applicable to this product.

NCBI GI #
56682959
NCBI GeneID
2495
NCBI Accession #
NP_002023.2
UniProt Primary Accession #
P02794
UniProt Secondary Accession #
Q3KRA8; Q3SWW1; B3KNR5
UniProt Related Accession #
P02794
GenBank Nucleotide #
NM_002032.2
NCBI Official Full Name
ferritin heavy chain
NCBI Official Synonym Full Names
ferritin, heavy polypeptide 1
NCBI Official Symbol
FTH1
NCBI Official Synonym Symbols
FHC; FTH; PLIF; FTHL6; PIG15
UniProt Protein Name
Ferritin heavy chain
UniProt Synonym Protein Names
Cell proliferation-inducing gene 15 protein
Protein Family
Iron transporter
UniProt Gene Name
FTH1
UniProt Synonym Gene Names
FTH; FTHL6; Ferritin H subunit
UniProt Entry Name
FRIH_HUMAN
NCBI Protein Information
ferritin heavy chain; apoferritin; ferritin H subunit; placenta immunoregulatory factor; proliferation-inducing protein 15; cell proliferation-inducing gene 15 protein

NCBI Summary for FTH1

This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
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UniProt Comments for FTH1

Ferritin-H: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited. Belongs to the ferritin family.

Protein type: Oxidoreductase; EC 1.16.3.1; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: ferritin complex; mitochondrion; cytosol; nucleus

Molecular Function: ferroxidase activity; protein binding; ferric iron binding; iron ion binding

Biological Process: receptor-mediated endocytosis; negative regulation of cell proliferation; cellular iron ion homeostasis; negative regulation of fibroblast proliferation; immune response; post-Golgi vesicle-mediated transport; iron ion transport; transmembrane transport; intracellular sequestering of iron ion

Disease: Hemochromatosis, Type 5
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Research Articles on FTH1

1. Data indicate that ferritin levels and hyperuricemia are two independently significant factors associated with alanine aminotransferase (ALT) elevation among obese adolescents.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FTH1 antibody

 Reference Product  PubMed Publications
 FTL antibody  >9 publications with FTH1 and FTL

Pathways associated with anti-FTH1 antibody

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Iron Metabolism In Placenta Pathway antibodies  Iron Metabolism In Placenta Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-FTH1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >9 publications with FTH1 and Neoplasms
 Inflammation Antibodies  >5 publications with FTH1 and Inflammation
 Adenocarcinoma Antibodies  >3 publications with FTH1 and Adenocarcinoma
 Disease Models, Animal Antibodies  >3 publications with FTH1 and Disease Models, Animal
 Liver Diseases Antibodies  >2 publications with FTH1 and Liver Diseases
 Nerve Degeneration Antibodies  >2 publications with FTH1 and Nerve Degeneration
 Nervous System Diseases Antibodies  >2 publications with FTH1 and Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >2 publications with FTH1 and Neurodegenerative Diseases
 Drug Toxicity Antibodies  >1 publications with FTH1 and Drug Toxicity
 Edema Antibodies  >1 publications with FTH1 and Edema
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