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FUCA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6477164

MBS6477164 is an antibody targeting FUCA2. Also known as FUCA2, NT (Fucosidase alpha-L-2 Plasma, Alpha-L-fucoside Fucohydrolase 2, Alpha-L-fucosidase 2, dJ20N2.5, MGC1314, Plasma alpha-L-fucosidase, PSEC0151, RP1-20N2.5, UNQ227/PRO260) (FITC). Reactive in… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FUCA2, Polyclonal Antibody
Full Product Name
FUCA2, NT (Fucosidase alpha-L-2 Plasma, Alpha-L-fucoside Fucohydrolase 2, Alpha-L-fucosidase 2, dJ20N2.5, MGC1314, Plasma alpha-L-fucosidase, PSEC0151, RP1-20N2.5, UNQ227/PRO260) (FITC)
Product Gene Name
anti-FUCA2 antibody
Product Synonym Names
EC=3.2.1.51
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human FUCA2.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
53.3 kDa (462aa)
OMIM
136820
3D Structure
ModBase 3D Structure for Q9BTY2
Immunogen
Synthetic peptide selected from the N-terminal region of human FUCA2 (KLH).
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-FUCA2 antibody

Antibodies; Enzymes
Applications Tested/Suitable for anti-FUCA2 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-FUCA2 antibody
IHC: 1:10-1:50
FLISA: 1:1,000
WB: 1:100-1:500
Applications are based on unconjugated antibody.

Immunohistochemistry (IHC) of anti-FUCA2 antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with FUCA2 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-FUCA2 Polyclonal Antibody – Cat# MBS6477164

Western Blot (WB) of anti-FUCA2 antibody

Western blot analysis of FUCA2 (arrow) using rabbit polyclonal FUCA2 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FUCA2 gene (Lane 2).
Rabbit Anti-FUCA2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6477164

Product References and Citations for anti-FUCA2 antibody

1. Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003). 2. Eiberg, H., et al., Clin. Genet. 26(1):23-29 (1984).

Other Notes

Small volumes of anti-FUCA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FUCA2. It may not necessarily be applicable to this product.

NCBI GI #
40068512
NCBI GeneID
2519
NCBI Accession #
NP_114409
UniProt Primary Accession #
Q9BTY2
UniProt Secondary Accession #
Q7Z6V1; Q7Z6Y2; Q8NBK4; E9PEB6
UniProt Related Accession #
Q9BTY2
GenBank Nucleotide #
NM_032020.4
NCBI Official Full Name
plasma alpha-L-fucosidase
NCBI Official Synonym Full Names
alpha-L-fucosidase 2
NCBI Official Symbol
FUCA2
NCBI Official Synonym Symbols
dJ20N2.5
UniProt Protein Name
Plasma alpha-L-fucosidase
UniProt Synonym Protein Names
Alpha-L-fucoside fucohydrolase 2; Alpha-L-fucosidase 2
Protein Family
Plasma alpha-L-fucosidase
UniProt Gene Name
FUCA2
UniProt Synonym Gene Names
Alpha-L-fucosidase 2
UniProt Entry Name
FUCO2_HUMAN
NCBI Protein Information
plasma alpha-L-fucosidase

NCBI Summary for FUCA2

This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010]
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UniProt Comments for FUCA2

FUCA2: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins. Belongs to the glycosyl hydrolase 29 family.

Protein type: Secreted; EC 3.2.1.51; Glycan Metabolism - other glycan degradation; Hydrolase; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6q24

Cellular Component: extracellular space; lysosome

Molecular Function: alpha-L-fucosidase activity; fucose binding

Biological Process: fucose metabolic process; glycoside catabolic process; response to bacterium
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Research Articles on FUCA2

1. Genetic polymorphisms within the FUCA2 and IL18 gene regions are also associated with diastolic function in SCD, likely by affecting expression levels of the genes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-FUCA2 antibody

 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Neutrophil Degranulation Pathway antibodies  Neutrophil Degranulation Pathway Diagram
 Other Glycan Degradation Pathway antibodies  Other Glycan Degradation Pathway Diagram
 Other Glycan Degradation Pathway antibodies  Other Glycan Degradation Pathway Diagram

Diseases associated with anti-FUCA2 antibody

 Disease Name  Pubmed Publications
 Abnormalities, Multiple Antibodies  >1 publications with FUCA2 and Abnormalities, Multiple
 Liver Diseases Antibodies  >1 publications with FUCA2 and Liver Diseases
 Kidney Diseases Antibodies  >1 publications with FUCA2 and Kidney Diseases
 Inflammation Antibodies  >1 publications with FUCA2 and Inflammation

Organs/Tissues associated with anti-FUCA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with FUCA2 and Blood
 Liver Antibodies  >1 publications with FUCA2 and Liver
 Stomach Antibodies  >1 publications with FUCA2 and Stomach
 Kidney Antibodies  >1 publications with FUCA2 and Kidney
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