• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

FZD1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9606380

Function: Receptor for Wnt proteins (PubMed:10557084). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084). Contradictory results showing activation by WNT7B have been… More details

$325 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FZD1, Polyclonal Antibody
Full Product Name
FZD1 Antibody
Product Gene Name
anti-FZD1 antibody
Product Synonym Names
Chfz-1; Dfrizzled-1; DKFZp564G072; FLJ95923; Frizzled 1; Frizzled homolog 1 (Drosophila); Frizzled homolog 1; Frizzled-1; Fz receptor 1; Fz-1; Fz1; FZD1; FZD1_HUMAN; FzE1; hFz1; Rfz1; Wnt receptor; Xfrizzled-1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
FZD1 antibody detects endogenous levels of total FZD1
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
FZD1 peptide (MBS9625097) is used for blocking the activity of FZD1 antibody (MBS9606380)
Molecular Weight
Observed: 71 kD
Predicted: 72 kDa
3D Structure
ModBase 3D Structure for Q9UP38
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide
Subcellular Location
Membrane. Cell Membrane.
Tissue Specificity
Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney.
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-FZD1 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-FZD1 antibody
WB: 1:500-1:1000
IF/ICC: 1:100-1:500

Western Blot (WB) of anti-FZD1 antibody

Western blot analysis of extracts from Jurkat cells, using FZD1 antibody.The lane on the left is treated with the antigen-specific peptide.
Rabbit Anti-FZD1 Polyclonal Antibody – Cat# MBS9606380

Immunofluorescene (IF) of anti-FZD1 antibody

MBS9606380 staining HeLa by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Rabbit Anti-FZD1 Polyclonal Antibody, Immunofluorescene (IF) – Cat# MBS9606380

Other Notes

Small volumes of anti-FZD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FZD1 purchase

MBS9606380 is an antibody targeting FZD1. Also known as FZD1 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FZD1. It may not necessarily be applicable to this product.

NCBI GI #
4503825
NCBI GeneID
8321
NCBI Accession #
NP_003496.1
UniProt Primary Accession #
Q9UP38
UniProt Secondary Accession #
O94815; Q549T8; A4D1E8
UniProt Related Accession #
Q9UP38
GenBank Nucleotide #
NM_003505.1
NCBI Official Full Name
frizzled-1
NCBI Official Synonym Full Names
frizzled class receptor 1
NCBI Official Symbol
FZD1
UniProt Protein Name
Frizzled-1
UniProt Synonym Protein Names
FzE1
Protein Family
Frizzled
UniProt Gene Name
FZD1
UniProt Synonym Gene Names
Fz-1; hFz1
NCBI Protein Information
frizzled-1

NCBI Summary for FZD1

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for FZD1

Receptor for Wnt proteins (PubMed:10557084). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084). Contradictory results showing activation by WNT7B have been described for mouse (). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
Show more

Research Articles on FZD1

1. aken together, our results suggest that Sp1 plays a role in human osteoblast differentiation and mineralization, which is at least partially mediated by Sp1-dependent transactivation of FZD1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FZD1 antibody

 Reference Product  PubMed Publications
 WNT5A antibody  >20 publications with FZD1 and WNT5A
 WNT3A antibody  >19 publications with FZD1 and WNT3A
 WNT3 antibody  >19 publications with FZD1 and WNT3
 WNT2 antibody  >9 publications with FZD1 and WNT2

Pathways associated with anti-FZD1 antibody

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram

Diseases associated with anti-FZD1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >29 publications with FZD1 and Neoplasms
 Breast Neoplasms Antibodies  >7 publications with FZD1 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >5 publications with FZD1 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >4 publications with FZD1 and Inflammation
 Death Antibodies  >4 publications with FZD1 and Death
 Hyperplasia Antibodies  >3 publications with FZD1 and Hyperplasia
 Carcinoma, Hepatocellular Antibodies  >2 publications with FZD1 and Carcinoma, Hepatocellular
 Leukemia Antibodies  >2 publications with FZD1 and Leukemia
 Colonic Neoplasms Antibodies  >2 publications with FZD1 and Colonic Neoplasms
 Disease Models, Animal Antibodies  >2 publications with FZD1 and Disease Models, Animal

Organs/Tissues associated with anti-FZD1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >20 publications with FZD1 and Bone
 Embryonic Tissue Antibodies  >14 publications with FZD1 and Embryonic Tissue
 Brain Antibodies  >12 publications with FZD1 and Brain
 Connective Tissue Antibodies  >8 publications with FZD1 and Connective Tissue
 Muscle Antibodies  >8 publications with FZD1 and Muscle
 Lung Antibodies  >8 publications with FZD1 and Lung
 Kidney Antibodies  >7 publications with FZD1 and Kidney
 Blood Antibodies  >6 publications with FZD1 and Blood
 Uterus Antibodies  >6 publications with FZD1 and Uterus
 Heart Antibodies  >6 publications with FZD1 and Heart
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000