Rabbit Anti-GAS41 Polyclonal Antibody – Cat# MBS6477898

Western blot analysis of anti-NuBI-1 Pab in HepG2 cell line lysate. NuBI-1(arrow) was detected using the purified Pab.

GAS41 Antibody – Rabbit Polyclonal

Name: GAS41 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6477898
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6477898

MBS6477898 is an antibody targeting GAS41. Also known as GAS41, NT (A31) (YEATS Domain-containing Protein 4, Glioma-amplified Sequence-41, Gas41, NuMA Binding Protein 1, NuBI-1, NuBI1, YEATS4, GAS41) (FITC). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GAS41, Polyclonal Antibody

Full Product Name

GAS41, NT (A31) (YEATS Domain-containing Protein 4, Glioma-amplified Sequence-41, Gas41, NuMA Binding Protein 1, NuBI-1, NuBI1, YEATS4, GAS41) (FITC)

Product Gene Name

anti-GAS41 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

Purity/Purification

Purified by Ammonium Sulfate Precipitation.

Specificity

Recognizes human NuBI-1.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer.

Molecular Weight

28.9 kDa (250aa), confirmed by MALDI-TOF

OMIM

602116

3D Structure

ModBase 3D Structure for O95619

Immunogen

Synthetic peptide selected from the N-terminal region of human NuBI-1 (KLH).

Conjugate

FITC

Note

Preservative Free

Product Categories/Family for anti-GAS41 antibody

Antibodies; Cancer Markers

Applications Tested/Suitable for anti-GAS41 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-GAS41 antibody

WB: 1:100-1:500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-GAS41 antibody

1. Cai, Y., et al., J. Biol. Chem. 278(44):42733-42736 (2003). 2. Lauffart, B., et al., Genomics 81(2):192-201 (2003). 3. Zimmermann, K., et al., J. Biol. Chem. 277(21):18626-18631 (2002). 4. Debernardi, S., et al., Blood 99(1):275-281 (2002). 5. Munnia, A., et al., Oncogene 20(35):4853-4863 (2001).

Other Notes

Small volumes of anti-GAS41 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GAS41. It may not necessarily be applicable to this product.

NCBI GI #

5729838

NCBI GeneID

8089

NCBI Accession #

NP_006521

UniProt Primary Accession #

O95619

UniProt Secondary Accession #

Q9NQD0

UniProt Related Accession #

O95619

GenBank Nucleotide #

NM_006530.3

NCBI Official Full Name

YEATS domain-containing protein 4 isoform 1

NCBI Official Synonym Full Names

YEATS domain containing 4

NCBI Official Symbol

YEATS4

NCBI Official Synonym Symbols

YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik

UniProt Protein Name

YEATS domain-containing protein 4

UniProt Synonym Protein Names

Glioma-amplified sequence 41; Gas41; NuMA-binding protein 1

UniProt Gene Name

YEATS4

UniProt Synonym Gene Names

GAS41; Gas41; NuBI-1; NuBI1

UniProt Entry Name

YETS4_HUMAN

NCBI Protein Information

YEATS domain-containing protein 4

NCBI Summary for GAS41

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

UniProt Comments for GAS41

YEATS4: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 12q13-q15

Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; nuclear matrix; cytoplasm; nucleolus

Molecular Function: protein C-terminus binding; protein binding; DNA binding; structural constituent of cytoskeleton; transcription factor activity

Biological Process: mitosis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of growth; positive regulation of transcription, DNA-dependent

Research Articles on GAS41

1. identified GAS41 as a novel target for endogenous miR-203 and demonstrate an inverse correlation of miR-203 expression with GAS41 in glioma cell lines

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GAS41 antibody

Reference Product	PubMed Publications
SMARCB1 antibody	>2 publications with GAS41 and SMARCB1
NUMA1 antibody	>2 publications with GAS41 and NUMA1
MLLT10 antibody	>2 publications with GAS41 and MLLT10
TFAP2B antibody	>1 publications with GAS41 and TFAP2B
TACC2 antibody	>1 publications with GAS41 and TACC2
TACC1 antibody	>1 publications with GAS41 and TACC1
PFDN1 antibody	>1 publications with GAS41 and PFDN1

Pathways associated with anti-GAS41 antibody

Products by Pathway	Pathway Diagram
Activation Of The TFAP2 (AP-2) Family Of Transcription Factors Pathway antibodies	Activation Of The TFAP2 (AP-2) Family Of Transcription Factors Pathway Diagram
C-MYB Transcription Factor Network Pathway antibodies	C-MYB Transcription Factor Network Pathway Diagram
Chromatin Modifying Enzymes Pathway antibodies	Chromatin Modifying Enzymes Pathway Diagram
Chromatin Organization Pathway antibodies	Chromatin Organization Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
HATs Acetylate Histones Pathway antibodies	HATs Acetylate Histones Pathway Diagram
Transcriptional Regulation By The AP-2 (TFAP2) Family Of Transcription Factors Pathway antibodies	Transcriptional Regulation By The AP-2 (TFAP2) Family Of Transcription Factors Pathway Diagram

Diseases associated with anti-GAS41 antibody

Disease Name	Pubmed Publications
Liposarcoma Antibodies	>5 publications with GAS41 and Liposarcoma
Breast Neoplasms Antibodies	>2 publications with GAS41 and Breast Neoplasms

Organs/Tissues associated with anti-GAS41 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>4 publications with GAS41 and Blood
Brain Antibodies	>3 publications with GAS41 and Brain
Mammary Gland Antibodies	>1 publications with GAS41 and Mammary Gland
Embryonic Tissue Antibodies	>1 publications with GAS41 and Embryonic Tissue
Testis Antibodies	>1 publications with GAS41 and Testis