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GBRR3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6301513

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (By similarity). More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GBRR3, Polyclonal Antibody
Full Product Name
GBRR3, NT (GABRR3, Gamma-aminobutyric acid receptor subunit rho-3, GABA(A) receptor subunit rho-3, GABA(C) receptor) (Biotin)
Product Gene Name
anti-GBRR3 antibody
Product Synonym Gene Name
GABRR3
Product Synonym Names
GABRR3; Gamma-aminobutyric acid receptor subunit rho-3; GABA(A) receptor subunit rho-3; GABA(C) receptor
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
54,272 Da
3D Structure
ModBase 3D Structure for A8MPY1
Immunogen
GBRR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-71 amino acids from the N-terminal region of human GBRR3.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-GBRR3 antibody

Antibodies; Receptors
Applications Tested/Suitable for anti-GBRR3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-GBRR3 antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-GBRR3 antibody

GBRR3 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the GBRR3 antibody detected the GBRR3 protein (arrow).
Rabbit Anti-GBRR3 Polyclonal Antibody – Cat# MBS6301513

Product References and Citations for anti-GBRR3 antibody

Craddock, N., et al. Mol. Psychiatry 15(2):146-153(2010). Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009): Muzny, D.M., et al. Nature 440(7088):1194-1198(2006). Alakuijala, A., et al. Brain Res. Dev. Brain Res. 154(1):15-23(2005). Croci, C., et al. J. Biol. Chem. 278(8):6128-6135(2003).

Other Notes

Small volumes of anti-GBRR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GBRR3 purchase

MBS6301513 is an antibody targeting GBRR3. Also known as GBRR3, NT (GABRR3, Gamma-aminobutyric acid receptor subunit rho-3, GABA(A) receptor subunit rho-3, GABA(C) receptor) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GBRR3. It may not necessarily be applicable to this product.

NCBI GI #
157743288
NCBI GeneID
200959
NCBI Accession #
NP_001099050.1
UniProt Primary Accession #
A8MPY1
UniProt Secondary Accession #
Q9UIV9
UniProt Related Accession #
A8MPY1
GenBank Nucleotide #
NM_001105580.2
NCBI Official Full Name
gamma-aminobutyric acid receptor subunit rho-3
NCBI Official Synonym Full Names
gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene)
NCBI Official Symbol
GABRR3
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit rho-3
UniProt Synonym Protein Names
GABA(A) receptor subunit rho-3; GABA(C) receptor
UniProt Gene Name
GABRR3
UniProt Entry Name
GBRR3_HUMAN
NCBI Protein Information
gamma-aminobutyric acid receptor subunit rho-3

NCBI Summary for GBRR3

The neurotransmitter gamma-aminobutyric acid (GABA) functions in the central nervous system to regulate synaptic transmission of neurons. This gene encodes one of three related subunits, which combine as homo- or hetero-pentamers to form GABA(C) receptors. In humans, some individuals contain a single-base polymorphism (dbSNP rs832032) that is predicted to inactivate the gene product. [provided by RefSeq, Jan 2012]
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UniProt Comments for GBRR3

GABRR3: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR3 sub-subfamily.

Protein type: Transporter; Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral; Transporter, ion channel

Chromosomal Location of Human Ortholog: 3q11.2

Cellular Component: postsynaptic membrane; plasma membrane; cell junction

Molecular Function: protein domain specific binding; chloride channel activity; GABA-A receptor activity; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; transmembrane transport; gamma-aminobutyric acid signaling pathway
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Research Articles on GBRR3

1. found no significant differences in either the frequencies of the GABRR1-M26V, GABRR1- H27R, GABRR2-T455M, and GABRR3-Y205X genotypes or in the frequencies of the allelic variants of these polymorphisms in patients with essential tremor

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GBRR3 antibody

 Reference Product  PubMed Publications
 GABRR1 antibody  >4 publications with GBRR3 and GABRR1
 GABRR2 antibody  >3 publications with GBRR3 and GABRR2
 GABRA4 antibody  >2 publications with GBRR3 and GABRA4
 GABRA5 antibody  >2 publications with GBRR3 and GABRA5

Pathways associated with anti-GBRR3 antibody

 Products by Pathway  Pathway Diagram
 GABA A (rho) Receptor Activation Pathway antibodies  GABA A (rho) Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-GBRR3 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with GBRR3 and Nervous System Diseases
 Schizophrenia Antibodies  >1 publications with GBRR3 and Schizophrenia
 Epilepsy Antibodies  >1 publications with GBRR3 and Epilepsy
 Inflammation Antibodies  >1 publications with GBRR3 and Inflammation
 Seizures Antibodies  >1 publications with GBRR3 and Seizures

Organs/Tissues associated with anti-GBRR3 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >2 publications with GBRR3 and Eye
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