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GCGR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7048240

G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role… More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GCGR, Polyclonal Antibody
Full Product Name
GCGR Antibody, Biotin conjugated
Product Gene Name
anti-GCGR antibody
Product Synonym Names
Glucagon receptorGL-R; GCGR
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
>95%, Protein G purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: GCGR (MBS7048237)
Biotin Conjugated Antibody: GCGR (MBS7048240)
Molecular Weight
54,009 Da
OMIM
U03469 mRNA
3D Structure
ModBase 3D Structure for P47871
Immunogen
Recombinant Human Glucagon receptor protein (26-136AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Conjugation
Biotin
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-34638 / sc-34640 / sc-34641 / sc-66912
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-GCGR antibody
ELISA (EIA)

Other Notes

Small volumes of anti-GCGR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GCGR purchase

MBS7048240 is an antibody targeting GCGR. Also known as GCGR Antibody, Biotin conjugated. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GCGR. It may not necessarily be applicable to this product.

NCBI GI #
4503947
NCBI GeneID
2642
NCBI Accession #
NP_000151.1
UniProt Primary Accession #
P47871
UniProt Secondary Accession #
Q2M3M5
UniProt Related Accession #
P47871
GenBank Nucleotide #
NM_000160.4
NCBI Official Full Name
glucagon receptor
NCBI Official Synonym Full Names
glucagon receptor
NCBI Official Symbol
GCGR
NCBI Official Synonym Symbols
GGR; GL-R
UniProt Protein Name
Glucagon receptor
Protein Family
Glucagon receptor
UniProt Gene Name
GCGR
UniProt Synonym Gene Names
GL-R
UniProt Entry Name
GLR_HUMAN
NCBI Protein Information
glucagon receptor

NCBI Summary for GCGR

The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]

UniProt Comments for GCGR

GCGR: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family.

Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function: glucagon receptor activity; guanyl-nucleotide exchange factor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; generation of precursor metabolites and energy; glucose homeostasis; regulation of blood pressure; response to nutrient; response to starvation

Disease: Diabetes Mellitus, Noninsulin-dependent
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Research Articles on GCGR

1. 2.5 A crystal structure of human GCGR in complex with the antagonist MK-0893, which is found to bind to an allosteric site outside the seven transmembrane helical bundle in a position between TM6 and TM7 extending into the lipid bilayer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GCGR antibody

 Reference Product  PubMed Publications
 GIP antibody  >7 publications with GCGR and GIP
 GCG antibody  >7 publications with GCGR and GCG
 CCK antibody  >2 publications with GCGR and CCK
 PTH antibody  >1 publications with GCGR and PTH
 VIP antibody  >1 publications with GCGR and VIP

Pathways associated with anti-GCGR antibody

 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Glucagon Signaling In Metabolic Regulation Pathway antibodies  Glucagon Signaling In Metabolic Regulation Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram

Diseases associated with anti-GCGR antibody

 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >21 publications with GCGR and Hyperplasia
 Diabetes Mellitus, Type 2 Antibodies  >20 publications with GCGR and Diabetes Mellitus, Type 2
 Weight Loss Antibodies  >10 publications with GCGR and Weight Loss
 Insulin Resistance Antibodies  >8 publications with GCGR and Insulin Resistance
 Liver Diseases Antibodies  >8 publications with GCGR and Liver Diseases
 Fatty Liver Antibodies  >6 publications with GCGR and Fatty Liver
 Cardiovascular Diseases Antibodies  >5 publications with GCGR and Cardiovascular Diseases
 Inflammation Antibodies  >4 publications with GCGR and Inflammation
 Hypertension Antibodies  >4 publications with GCGR and Hypertension
 Hypertrophy Antibodies  >3 publications with GCGR and Hypertrophy

Organs/Tissues associated with anti-GCGR antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >38 publications with GCGR and Liver
 Pancreas Antibodies  >30 publications with GCGR and Pancreas
 Kidney Antibodies  >6 publications with GCGR and Kidney
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