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GEMIN6 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649940

GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN, GEMIN2, GEMIN3 (DDX20),… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GEMIN6, Polyclonal Antibody
Full Product Name
GEMIN6 (Gem-associated Protein 6, Gemin-6, SIP2, FLJ23459)
Product Gene Name
Product Synonym Names
Anti -GEMIN6 (Gem-associated Protein 6, Gemin-6, SIP2, FLJ23459)
Immunogen Sequence
MSEWMKKGPL EWQDYIYKEV RVTASEKNEY KGWVLTTDPV SANIVLVNFL EDGSMSVTGI MGHAVQTVET MNEGDHRVRE KLMHLFTSGD CKAYSPEDLE ERKNSLKKWL EKNHIPITEQ GDAPRTLCVA GVLTIDPPYD PENCSSSNEI ILSRVQDLIE GHLTASQ
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human GEMIN6.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
18,824 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (39005327..39009598). Location: 2p22.1
OMIM
607006
3D Structure
ModBase 3D Structure for Q8WXD5
Immunogen
Full length human GEMIN6, aa1-167 (AAH18195.1).
Applications Tested/Suitable for anti-GEMIN6 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-GEMIN6 antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-GEMIN6 antibody

GEMIN6 polyclonal antibody. Western Blot analysis of GEMIN6 expression in HeLa.
Mouse Anti-GEMIN6 Polyclonal Antibody – Cat# MBS649940

Western Blot (WB) of anti-GEMIN6 antibody

Western Blot analysis of GEMIN6 expression in transfected 293T cell line by GEMIN6 polyclonal antibody. Lane 1: GEMIN6 transfected lysate (18.37kD). Lane 2: Non-transfected lysate.
Mouse Anti-GEMIN6 Polyclonal Antibody, Western Blot (WB) – Cat# MBS649940

Immunofluorescence (IF) of anti-GEMIN6 antibody

Immunofluorescence of purified antibody to GEMIN6 on HeLa cell. [antibody concentration 10ug/ml].
Mouse Anti-GEMIN6 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS649940

Other Notes

Small volumes of anti-GEMIN6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GEMIN6 purchase

MBS649940 is an antibody targeting GEMIN6. Also known as GEMIN6 (Gem-associated Protein 6, Gemin-6, SIP2, FLJ23459). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for GEMIN6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
gem-associated protein 6
NCBI Official Synonym Full Names
gem (nuclear organelle) associated protein 6
NCBI Official Symbol
GEMIN6
UniProt Protein Name
Gem-associated protein 6
UniProt Synonym Protein Names
SIP2
UniProt Gene Name
GEMIN6
UniProt Synonym Gene Names
Gemin-6
UniProt Entry Name
GEMI6_HUMAN
NCBI Protein Information
gem-associated protein 6; SIP2; gemin 6; gemin-6

NCBI Summary for GEMIN6

GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002]
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UniProt Comments for GEMIN6

Function: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. Ref.1

Subunit structure: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts directly with GEMIN7, SNRPB, SNRPD2, SNRPD3 and SNRPE. Ref.1 Ref.6 Ref.10

Subcellular location: Nucleus › nucleoplasm. Nucleus › gem. Cytoplasm. Note: Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm. Ref.1

Sequence caution: The sequence BAB15660.1 differs from that shown. Reason: Frameshift at position 142.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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