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GGH Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649766

This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq]. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GGH, Polyclonal Antibody
Full Product Name
GGH, NT (GGH, Gamma-glutamyl hydrolase, Conjugase, GH, Gamma-Glu-X carboxypeptidase)
Product Gene Name
anti-GGH antibody
Product Synonym Names
Anti -GGH, NT (GGH, Gamma-glutamyl hydrolase, Conjugase, GH, Gamma-Glu-X carboxypeptidase)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
35,964 Da
Chromosome Location
Chromosome: 8; NC_000008.10 (63927638..63951610, complement). Location: 8q12.3
OMIM
601509
3D Structure
ModBase 3D Structure for Q92820
Immunogen
GGH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human GGH.

Product Categories/Family for anti-GGH antibody

Antibodies; Abs to Enzymes; Carboxypeptidase
Applications Tested/Suitable for anti-GGH antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-GGH antibody
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-GGH antibody

GGH Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the GGH antibody detected the GGH protein (arrow).
Rabbit Anti-GGH Polyclonal Antibody – Cat# MBS649766

Immunohistochemistry (IHC) of anti-GGH antibody

GGH Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GGH Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-GGH Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS649766

Flow Cytometry (FC/FACS) of anti-GGH antibody

GGH Antibody (N-term) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-GGH Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS649766

Other Notes

Small volumes of anti-GGH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GGH purchase

MBS649766 is an antibody targeting GGH. Also known as GGH, NT (GGH, Gamma-glutamyl hydrolase, Conjugase, GH, Gamma-Glu-X carboxypeptidase). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GGH. It may not necessarily be applicable to this product.

NCBI GI #
4503987
NCBI GeneID
8836
NCBI Accession #
NP_003869.1
UniProt Primary Accession #
Q92820
UniProt Related Accession #
Q92820
GenBank Nucleotide #
NM_003878.2
NCBI Official Full Name
gamma-glutamyl hydrolase
NCBI Official Synonym Full Names
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
NCBI Official Symbol
GGH
NCBI Official Synonym Symbols
GH
UniProt Protein Name
Gamma-glutamyl hydrolase
UniProt Synonym Protein Names
Conjugase; GH; Gamma-Glu-X carboxypeptidase
Protein Family
Gamma-glutamyl hydrolase
UniProt Gene Name
GGH
UniProt Entry Name
GGH_HUMAN
NCBI Protein Information
gamma-glutamyl hydrolase; gamma-Glu-X carboxypeptidase

NCBI Summary for GGH

This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]

UniProt Comments for GGH

Function: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.

Catalytic activity: Hydrolysis of a gamma-glutamyl bond.

Subunit structure: Homodimer. Ref.7 Ref.10

Subcellular location: Secreted › extracellular space. Lysosome. Melanosome. Note: While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.6 Ref.8

Sequence similarities: Belongs to the peptidase C26 family.Contains 1 gamma-glutamyl hydrolase domain.
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Research Articles on GGH

1. GG genotype of GGH -354 T > G polymorphism may have high predictive value for myelosuppression in methotrexate treated rheumatoid arthritis patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GGH antibody

 Reference Product  PubMed Publications
 FPGS antibody  >26 publications with GGH and FPGS
 DHFR antibody  >8 publications with GGH and DHFR
 GSTP1 antibody  >2 publications with GGH and GSTP1
 GSTA4 antibody  >1 publications with GGH and GSTA4

Pathways associated with anti-GGH antibody

 Products by Pathway  Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Glutamate Removal From Folates Pathway antibodies  Glutamate Removal From Folates Pathway Diagram
 Glutathione-mediated Detoxification I Pathway antibodies  Glutathione-mediated Detoxification I Pathway Diagram

Diseases associated with anti-GGH antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >49 publications with GGH and Neoplasms
 Neoplasms, Experimental Antibodies  >9 publications with GGH and Neoplasms, Experimental
 Colorectal Neoplasms Antibodies  >9 publications with GGH and Colorectal Neoplasms
 Liver Diseases Antibodies  >7 publications with GGH and Liver Diseases
 Hepatitis Antibodies  >6 publications with GGH and Hepatitis
 Inflammation Antibodies  >4 publications with GGH and Inflammation
 Carcinoma, Hepatocellular Antibodies  >3 publications with GGH and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >3 publications with GGH and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >3 publications with GGH and Breast Neoplasms
 Liver Neoplasms Antibodies  >3 publications with GGH and Liver Neoplasms

Organs/Tissues associated with anti-GGH antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >23 publications with GGH and Blood
 Liver Antibodies  >13 publications with GGH and Liver
 Intestine Antibodies  >11 publications with GGH and Intestine
 Bone Antibodies  >8 publications with GGH and Bone
 Lung Antibodies  >8 publications with GGH and Lung
 Brain Antibodies  >8 publications with GGH and Brain
 Vascular Antibodies  >3 publications with GGH and Vascular
 Connective Tissue Antibodies  >3 publications with GGH and Connective Tissue
 Bone Marrow Antibodies  >3 publications with GGH and Bone Marrow
 Embryonic Tissue Antibodies  >3 publications with GGH and Embryonic Tissue
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