Rabbit Anti-GLDN Polyclonal Antibody – Cat# MBS6302517

Western blot analysis in A549 cell line lysates (35ug/lane) using 0350756. This demonstrates 0350756 detected the GLDN protein (arrow).

GLDN Antibody – Rabbit Polyclonal

Name: GLDN Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6302517
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6302517

GLDN plays a role in the formation of the nodes of Ranvier along myelinated axons. Probable NRCAM and NFASC/neurofascin ligand which may provide a glial positional clue required for the proper molecular assembly of the nodes of Ranvier (By similarity). More details

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GLDN, Polyclonal Antibody

Full Product Name

GLDN, ID (GLDN, COLM, Gliomedin) (MaxLight 405)

Product Gene Name

anti-GLDN antibody

Product Synonym Names

GLDN; COLM; Gliomedin

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

Purity/Purification

Purified by Protein A and Peptide Affinity Chromatography.

Specificity

Recognizes human GLDN.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

45,822 Da

3D Structure

ModBase 3D Structure for Q6ZMI3

Immunogen

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 271-299 in the central region of human GLDN, UniProt Accession # Q6ZMI3; NP_861454.2.

Conjugate

MaxLight405

Note

Preservative Free

Product Categories/Family for anti-GLDN antibody

Antibodies; Proteins

Applications Tested/Suitable for anti-GLDN antibody

Western Blot (WB), FLISA

Application Notes for anti-GLDN antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-GLDN antibody

Eshed, Y., et al. Neuron 47(2):215-229(2005). Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003). Graveel, C.R., et al. Oncogene 22(11):1730-1736(2003).

Other Notes

Small volumes of anti-GLDN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLDN purchase

MBS6302517 is an antibody targeting GLDN. Also known as GLDN, ID (GLDN, COLM, Gliomedin) (MaxLight 405). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GLDN. It may not necessarily be applicable to this product.

NCBI GI #

98986321

NCBI GeneID

342035

NCBI Accession #

NP_861454.2

UniProt Primary Accession #

Q6ZMI3

UniProt Secondary Accession #

Q6UXZ7; Q7Z359

UniProt Related Accession #

Q6ZMI3

GenBank Nucleotide #

NM_181789.3

NCBI Official Full Name

gliomedin isoform 1

NCBI Official Synonym Full Names

gliomedin

NCBI Official Symbol

GLDN

NCBI Official Synonym Symbols

CLOM; COLM; CRGL2; CRG-L2; LCCS11; UNC-112

UniProt Protein Name

Gliomedin

Protein Family

Gliomedin

UniProt Gene Name

GLDN

UniProt Synonym Gene Names

COLM

NCBI Protein Information

gliomedin

NCBI Summary for GLDN

This gene encodes a protein that contains olfactomedin-like and collagen-like domains. The encoded protein, which exists in both transmembrane and secreted forms, promotes formation of the nodes of Ranvier in the peripheral nervous system. Mutations in this gene cause a form of lethal congenital contracture syndrome in human patients. Autoantibodies to the encoded protein have been identified in sera form patients with multifocal motor neuropathy. [provided by RefSeq, May 2017]

UniProt Comments for GLDN

Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.

Research Articles on GLDN

1. Our findings expand the genotypic and phenotypic spectrum of LCCS11 and demonstrate that the condition may not necessarily be lethal in the neonatal period.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GLDN antibody

Reference Product	PubMed Publications
NFASC antibody	>1 publications with GLDN and NFASC
NRCAM antibody	>1 publications with GLDN and NRCAM