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GLUD2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6302737

The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is… More details

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Product Overview

Online Datasheet in PDF
Product Name
GLUD2, Polyclonal Antibody
Full Product Name
GLUD2, NT (GLUD2, GLUDP1, Glutamate dehydrogenase 2, mitochondrial) (MaxLight 405)
Product Gene Name
anti-GLUD2 antibody
Product Synonym Names
GLUD2; GLUDP1; Glutamate dehydrogenase 2, mitochondrial
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human GLUD2.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
61,434 Da
Chromosome Location
Chromosome: X; NC_000023.10 (120181462..120183796). Location: Xq24-q25
OMIM
300144
3D Structure
ModBase 3D Structure for P49448
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 75-103 in the N-terminal region of human GLUD2. Cellular Localization: Mitochondrial matrix
Conjugate
MaxLight405
Note
Preservative Free

Product Categories/Family for anti-GLUD2 antibody

Antibodies; Mitochondrial Proteins
Applications Tested/Suitable for anti-GLUD2 antibody
Western Blot (WB), FLISA
Application Notes for anti-GLUD2 antibody
Applications are based on unconjugated antibody.

Product References and Citations for anti-GLUD2 antibody

1. Spanaki, C., et al. J. Biol. Chem. 285(22):16748-16756(2010). 2. Plaitakis, A., et al. Eur. J. Hum. Genet. 18(3):336-341(2010). 3. Zaganas, I., et al. Neurochem. Int. 55 (1-3), 52-63 (2009). 4. Mastorodemos, V., et al. Biochem. Cell Biol. 87(3):505-516(2009). 5. Kanavouras, K., et al. J. Neurochem. 109 SUPPL 1, 167-173 (2009).

Other Notes

Small volumes of anti-GLUD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLUD2 purchase

MBS6302737 is an antibody targeting GLUD2. Also known as GLUD2, NT (GLUD2, GLUDP1, Glutamate dehydrogenase 2, mitochondrial) (MaxLight 405). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GLUD2. It may not necessarily be applicable to this product.

NCBI GI #
31377775
NCBI GeneID
2747
NCBI Accession #
NP_036216.2
UniProt Primary Accession #
P49448
UniProt Secondary Accession #
Q9UDQ4; B2R8G0
UniProt Related Accession #
P49448
GenBank Nucleotide #
NM_012084.3
NCBI Official Full Name
glutamate dehydrogenase 2, mitochondrial
NCBI Official Synonym Full Names
glutamate dehydrogenase 2
NCBI Official Symbol
GLUD2
NCBI Official Synonym Symbols
GDH2; GLUDP1
UniProt Protein Name
Glutamate dehydrogenase 2, mitochondrial
Protein Family
Glutamate receptor ionotropic
UniProt Gene Name
GLUD2
UniProt Synonym Gene Names
GLUDP1; GDH 2
UniProt Entry Name
DHE4_HUMAN
NCBI Protein Information
glutamate dehydrogenase 2, mitochondrial; GDH 2; glutamate dehydrogenase pseudogene 1

UniProt Comments for GLUD2

Function: Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.

Catalytic activity: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.

Subunit structure: Homohexamer

By similarity.

Subcellular location: Mitochondrion matrix Ref.7.

Tissue specificity: Expressed in retina, testis and, at a lower level, brain.

Post-translational modification: Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer.

Sequence similarities: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
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Research Articles on GLUD2

1. first N-terminal alpha helical structure is crucial for the mitochondrial import of hGDH2 and these findings may have implications in understanding the evolutionary mechanisms that led to the large mitochondrial targeting signals of human GDHs

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GLUD2 antibody

 Products by Pathway  Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 D-Glutamine And D-glutamate Metabolism Pathway antibodies  D-Glutamine And D-glutamate Metabolism Pathway Diagram
 D-Glutamine And D-glutamate Metabolism Pathway antibodies  D-Glutamine And D-glutamate Metabolism Pathway Diagram
 Nitrogen Metabolism Pathway antibodies  Nitrogen Metabolism Pathway Diagram
 Nitrogen Metabolism Pathway antibodies  Nitrogen Metabolism Pathway Diagram
 Proximal Tubule Bicarbonate Reclamation Pathway antibodies  Proximal Tubule Bicarbonate Reclamation Pathway Diagram
 Proximal Tubule Bicarbonate Reclamation Pathway antibodies  Proximal Tubule Bicarbonate Reclamation Pathway Diagram

Diseases associated with anti-GLUD2 antibody

 Disease Name  Pubmed Publications
 Movement Disorders Antibodies  >3 publications with GLUD2 and Movement Disorders
 Depressive Disorder Antibodies  >1 publications with GLUD2 and Depressive Disorder
 Necrosis Antibodies  >1 publications with GLUD2 and Necrosis
 Learning Disorders Antibodies  >1 publications with GLUD2 and Learning Disorders
 Nerve Degeneration Antibodies  >1 publications with GLUD2 and Nerve Degeneration
 Immune System Diseases Antibodies  >1 publications with GLUD2 and Immune System Diseases
 Neoplasms Antibodies  >1 publications with GLUD2 and Neoplasms
 Disease Models, Animal Antibodies  >1 publications with GLUD2 and Disease Models, Animal

Organs/Tissues associated with anti-GLUD2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >34 publications with GLUD2 and Brain
 Testis Antibodies  >7 publications with GLUD2 and Testis
 Kidney Antibodies  >3 publications with GLUD2 and Kidney
 Blood Antibodies  >2 publications with GLUD2 and Blood
 Pancreas Antibodies  >1 publications with GLUD2 and Pancreas
 Liver Antibodies  >1 publications with GLUD2 and Liver
 Muscle Antibodies  >1 publications with GLUD2 and Muscle
 Eye Antibodies  >1 publications with GLUD2 and Eye
 Embryonic Tissue Antibodies  >1 publications with GLUD2 and Embryonic Tissue
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