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GP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6303383

MBS6303383 is an antibody targeting GP2. Also known as GP2, NT (GP2, Pancreatic secretory granule membrane major glycoprotein GP2, Pancreatic zymogen granule membrane protein GP-2, ZAP75) (Biotin). Reactive in Human. Host: Rabbit. The specific function of… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GP2, Polyclonal Antibody
Full Product Name
GP2, NT (GP2, Pancreatic secretory granule membrane major glycoprotein GP2, Pancreatic zymogen granule membrane protein GP-2, ZAP75) (Biotin)
Product Gene Name
Product Synonym Names
GP2; Pancreatic secretory granule membrane major glycoprotein GP2; Pancreatic zymogen granule membrane protein GP-2; ZAP75
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
43,039 Da
OMIM
602977
3D Structure
ModBase 3D Structure for P55259
Immunogen
GP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-85 amino acids from the N-terminal region of human GP2.
Conjugate
Biotin
Note
Preservative Free
Applications Tested/Suitable for anti-GP2 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-GP2 antibody
IHC: 1:10-50
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-GP2 antibody

GP2 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the GP2 antibody detected the GP2 protein (arrow).
Rabbit Anti-GP2 Polyclonal Antibody – Cat# MBS6303383

Immunohistochemistry (IHC) of anti-GP2 antibody

GP2 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GP2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-GP2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6303383

Product References and Citations for anti-GP2 antibody

Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010). Masson, E., et al. Pancreas 39(3):353-358(2010). Witt, H., et al. Pancreas 39(2):188-192(2010). Boulling, A., et al. Mol. Genet. Metab. 99(3):319-324(2010). Hase, K., et al. Nature 462(7270):226-230(2009).

Other Notes

Small volumes of anti-GP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GP2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
pancreatic secretory granule membrane major glycoprotein GP2 isoform 1 preproprotein
NCBI Official Synonym Full Names
glycoprotein 2 (zymogen granule membrane)
NCBI Official Symbol
GP2
NCBI Official Synonym Symbols
ZAP75
UniProt Protein Name
Pancreatic secretory granule membrane major glycoprotein GP2
UniProt Synonym Protein Names
Pancreatic zymogen granule membrane protein GP-2; ZAP75
UniProt Gene Name
GP2
UniProt Entry Name
GP2_HUMAN
NCBI Protein Information
pancreatic secretory granule membrane major glycoprotein GP2; pancreatic zymogen granule membrane associated protein GP2

NCBI Summary for GP2

This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
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UniProt Comments for GP2

GP2: 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 16p12

Cellular Component: apical plasma membrane

Molecular Function: antigen binding

Biological Process: antigen transcytosis by M cells in mucosal-associated lymphoid tissue
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GP2 antibody

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