Rabbit Anti-GRB10 Polyclonal Antibody – Cat# MBS9447357

GRB10 Antibody – Rabbit Polyclonal

Name: GRB10 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9447357
Price: 435 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9447357

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin… More details

$435 / 0.1 mL (Biotin) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GRB10, Polyclonal Antibody

Full Product Name

GRB10 Conjugated Antibody

Product Gene Name

anti-GRB10 antibody

Product Synonym Names

RSS; IRBP; MEG1; GRB-IR; Grb-10

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

Specificity

The antibody detects endogenous levels of total GRB10 protein.

Preparation and Storage

Store at 4 degree C for 6 months.

Molecular Weight

66,487 Da

OMIM

601523

3D Structure

ModBase 3D Structure for Q13322

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human growth factor receptor-bound protein 10

Conjugation

Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750

Excitation Emission

AF350: 346nm/442nm

Applications Tested/Suitable for anti-GRB10 antibody

Most Applications

Application Notes for anti-GRB10 antibody

Suggested Dilution:
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000

Other Notes

Small volumes of anti-GRB10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRB10 purchase

MBS9447357 is an antibody targeting GRB10. Also known as GRB10 Conjugated Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GRB10. It may not necessarily be applicable to this product.

NCBI GI #

48762679

NCBI GeneID

2887

NCBI Accession #

NP_005302

UniProt Primary Accession #

Q13322

UniProt Secondary Accession #

O00427; O00701; O75222; Q92606; Q92907; Q92948; A4D258; A7VJ95; A8K0E6; D3DVM9

UniProt Related Accession #

Q13322

GenBank Nucleotide #

NM_005311.4

NCBI Official Full Name

growth factor receptor-bound protein 10 isoform a

NCBI Official Synonym Full Names

growth factor receptor-bound protein 10

NCBI Official Symbol

GRB10

NCBI Official Synonym Symbols

RSS; IRBP; MEG1; GRB-IR; Grb-10

UniProt Protein Name

Growth factor receptor-bound protein 10

UniProt Synonym Protein Names

GRB10 adapter protein; Insulin receptor-binding protein Grb-IR

Protein Family

Growth factor receptor-bound protein

UniProt Gene Name

GRB10

UniProt Synonym Gene Names

GRBIR; KIAA0207

UniProt Entry Name

GRB10_HUMAN

NCBI Protein Information

growth factor receptor-bound protein 10; GRB10 adapter protein; GRB10 adaptor protein; maternally expressed gene 1; insulin receptor-binding protein Grb-IR

UniProt Comments for GRB10

GRB10: an adaptor protein that inhibits insulin-stimulated IRS-PI (3)K-Akt signaling pathway by disrupting the association of IRS with the insulin receptor. Also binds activated PDGFR and EGFR. Preferentially localizes to the mitochondria, modulating the anti-apoptotic activity of mitochondrial Raf-1. Can translocate to the plasma membrane and lamellipodia. Three alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7p12.2

Cellular Component: cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; SH3/SH2 adaptor activity; insulin receptor binding

Biological Process: negative regulation of glucose import; negative regulation of Wnt receptor signaling pathway; insulin-like growth factor receptor signaling pathway; insulin receptor signaling pathway; negative regulation of phosphorylation; negative regulation of insulin receptor signaling pathway; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of phosphorylation; response to insulin stimulus; negative regulation of glycogen biosynthetic process

Research Articles on GRB10

1. Tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GRB10 antibody

Reference Product	PubMed Publications
IGF1R antibody	>27 publications with GRB10 and IGF1R
NEDD4 antibody	>8 publications with GRB10 and NEDD4
AKT1 antibody	>6 publications with GRB10 and AKT1
RET antibody	>5 publications with GRB10 and RET
KIT antibody	>3 publications with GRB10 and KIT
RAF1 antibody	>3 publications with GRB10 and RAF1
GIGYF1 antibody	>3 publications with GRB10 and GIGYF1
PDGFRB antibody	>1 publications with GRB10 and PDGFRB
INSR antibody	>1 publications with GRB10 and INSR

Pathways associated with anti-GRB10 antibody

Products by Pathway	Pathway Diagram
EGFR1 Signaling Pathway antibodies	EGFR1 Signaling Pathway Diagram
IGF1 Pathway antibodies	IGF1 Pathway Diagram
IRS Activation Pathway antibodies	IRS Activation Pathway Diagram
IRS-related Events Pathway antibodies	IRS-related Events Pathway Diagram
Insulin Pathway antibodies	Insulin Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Insulin Receptor Signalling Cascade Pathway antibodies	Insulin Receptor Signalling Cascade Pathway Diagram
Kit Receptor Signaling Pathway antibodies	Kit Receptor Signaling Pathway Diagram
PDGFR-beta Signaling Pathway antibodies	PDGFR-beta Signaling Pathway Diagram
SHC Activation Pathway antibodies	SHC Activation Pathway Diagram

Diseases associated with anti-GRB10 antibody

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>15 publications with GRB10 and Brain Diseases
Nervous System Diseases Antibodies	>15 publications with GRB10 and Nervous System Diseases
Fetal Growth Retardation Antibodies	>11 publications with GRB10 and Fetal Growth Retardation
Disease Models, Animal Antibodies	>8 publications with GRB10 and Disease Models, Animal
Breast Neoplasms Antibodies	>7 publications with GRB10 and Breast Neoplasms
Weight Loss Antibodies	>5 publications with GRB10 and Weight Loss
Carcinoma Antibodies	>5 publications with GRB10 and Carcinoma
Cardiovascular Diseases Antibodies	>4 publications with GRB10 and Cardiovascular Diseases
Cognition Disorders Antibodies	>3 publications with GRB10 and Cognition Disorders
Kidney Diseases Antibodies	>3 publications with GRB10 and Kidney Diseases

Organs/Tissues associated with anti-GRB10 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>32 publications with GRB10 and Brain
Muscle Antibodies	>29 publications with GRB10 and Muscle
Blood Antibodies	>27 publications with GRB10 and Blood
Embryonic Tissue Antibodies	>23 publications with GRB10 and Embryonic Tissue
Liver Antibodies	>18 publications with GRB10 and Liver
Placenta Antibodies	>17 publications with GRB10 and Placenta
Kidney Antibodies	>15 publications with GRB10 and Kidney
Vascular Antibodies	>10 publications with GRB10 and Vascular
Heart Antibodies	>9 publications with GRB10 and Heart
Pancreas Antibodies	>9 publications with GRB10 and Pancreas