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GRHPR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3221918

This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in… More details

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Product Overview

Online Datasheet in PDF
Product Name
GRHPR, Polyclonal Antibody
Full Product Name
GRHPR Antibody - N-terminal region
Product Gene Name
anti-GRHPR antibody
Product Synonym Gene Name
PH2; GLXR; GLYD
Immunogen Sequence
Synthetic peptide located within the following region: PAEGRVALAR AADCEVEQWD SDEPIPAKEL ERGVAGAHGL LCLLSDHVDK
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
GRHPR peptide (MBS3246636) is used for blocking the activity of GRHPR antibody (MBS3221918)
Molecular Weight
36 kDa
OMIM
phenotype 604296
3D Structure
ModBase 3D Structure for Q9UBQ7
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human GRHPR

Product Categories/Family for anti-GRHPR antibody

Polyclonal; Cell Biology; Disease Related
Applications Tested/Suitable for anti-GRHPR antibody
Western Blot (WB)

Western Blot (WB) of anti-GRHPR antibody

Host: Rabbit
Target Name: GRHPR
Sample Tissue: Human DLD1 Whole Cell lysates
Antibody Dilution: 1ug/ml
Rabbit Anti-GRHPR Polyclonal Antibody – Cat# MBS3221918

Other Notes

Small volumes of anti-GRHPR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRHPR purchase

MBS3221918 is an antibody targeting GRHPR. Also known as GRHPR Antibody - N-terminal region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GRHPR. It may not necessarily be applicable to this product.

NCBI GI #
6912396
NCBI GeneID
9380
NCBI Accession #
NP_036335.1
UniProt Primary Accession #
Q9UBQ7
UniProt Related Accession #
Q9UBQ7
GenBank Nucleotide #
NM_012203.1
NCBI Official Full Name
glyoxylate reductase/hydroxypyruvate reductase
NCBI Official Synonym Full Names
glyoxylate and hydroxypyruvate reductase
NCBI Official Symbol
GRHPR
NCBI Official Synonym Symbols
PH2; GLXR; GLYD
UniProt Protein Name
Glyoxylate reductase/hydroxypyruvate reductase
Protein Family
Glyoxylate reductase/hydroxypyruvate reductase
UniProt Gene Name
GRHPR
UniProt Synonym Gene Names
GLXR
UniProt Entry Name
GRHPR_HUMAN
NCBI Protein Information
glyoxylate reductase/hydroxypyruvate reductase

UniProt Comments for GRHPR

GRHPR: Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2); also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L- glycerate. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Protein type: Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; Oxidoreductase; EC 1.1.1.79; EC 1.1.1.81

Chromosomal Location of Human Ortholog: 9q12

Cellular Component: peroxisomal matrix; cytoplasm; cytosol

Molecular Function: glyoxylate reductase (NADP) activity; protein homodimerization activity; carboxylic acid binding; hydroxypyruvate reductase activity; NAD binding; glycerate dehydrogenase activity

Biological Process: dicarboxylic acid metabolic process; glyoxylate metabolic process; metabolic process; excretion; protein oligomerization

Disease: Hyperoxaluria, Primary, Type Ii
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Research Articles on GRHPR

1. GRHPR was genotyped in Japanese patients with PH2 and all GRHPR mutations described to date were reviewed in terms of geographic and ethnic association

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GRHPR antibody

 Reference Product  PubMed Publications
 AGXT antibody  >11 publications with GRHPR and AGXT

Pathways associated with anti-GRHPR antibody

 Products by Pathway  Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Glyoxylate Metabolism Pathway antibodies  Glyoxylate Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Pyruvate Metabolism Pathway antibodies  Pyruvate Metabolism Pathway Diagram
 Pyruvate Metabolism Pathway antibodies  Pyruvate Metabolism Pathway Diagram

Diseases associated with anti-GRHPR antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >22 publications with GRHPR and Kidney Diseases
 Primary hyperoxaluria type 2 Antibodies  >15 publications with GRHPR and Primary hyperoxaluria type 2
 Liver Diseases Antibodies  >5 publications with GRHPR and Liver Diseases
 Hypertension Antibodies  >4 publications with GRHPR and Hypertension
 Cell Transformation, Neoplastic Antibodies  >1 publications with GRHPR and Cell Transformation, Neoplastic
 Carcinoma, Hepatocellular Antibodies  >1 publications with GRHPR and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with GRHPR and Liver Neoplasms
 Inflammation Antibodies  >1 publications with GRHPR and Inflammation
 Necrosis Antibodies  >1 publications with GRHPR and Necrosis

Organs/Tissues associated with anti-GRHPR antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >16 publications with GRHPR and Kidney
 Liver Antibodies  >15 publications with GRHPR and Liver
 Blood Antibodies  >6 publications with GRHPR and Blood
 Thyroid Antibodies  >1 publications with GRHPR and Thyroid
 Bone Antibodies  >1 publications with GRHPR and Bone
 Eye Antibodies  >1 publications with GRHPR and Eye
 Skin Antibodies  >1 publications with GRHPR and Skin
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