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GRIN3B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8322826

MBS8322826 is an antibody targeting GRIN3B. Reactive in Human. Host: Rabbit. Rabbit polyclonal antibody to GRIN3B More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GRIN3B, Polyclonal Antibody
Full Product Name
Anti-GRIN3B Antibody
Product Gene Name
anti-GRIN3B antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of GRIN3B protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
112,992 Da
OMIM
606651
3D Structure
ModBase 3D Structure for O60391
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-terminal region of human GRIN3B. The exact sequence is proprietary.

Product Categories/Family for anti-GRIN3B antibody

Primary Antibodies
Applications Tested/Suitable for anti-GRIN3B antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-GRIN3B antibody
WB: 1/500-1/1000
IHC: 1/50-1/200

Western Blot (WB) of anti-GRIN3B antibody

Western blot analysis of GRIN3B expression in A549 (A) whole cell lysates. (Predicted band size: 112 kD; Observed band size: 105 kD)
Rabbit Anti-GRIN3B Polyclonal Antibody – Cat# MBS8322826

Immunohistochemistry (IHC) of anti-GRIN3B antibody

Immunohistochemical analysis of GRIN3B staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-GRIN3B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS8322826

Other Notes

Small volumes of anti-GRIN3B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GRIN3B. It may not necessarily be applicable to this product.

NCBI GI #
62988346
NCBI GeneID
116444
NCBI Accession #
NP_619635.1
UniProt Primary Accession #
O60391
UniProt Secondary Accession #
Q5EAK7; Q7RTW9
UniProt Related Accession #
O60391
GenBank Nucleotide #
NM_138690.2
NCBI Official Full Name
glutamate receptor ionotropic, NMDA 3B
NCBI Official Synonym Full Names
glutamate ionotropic receptor NMDA type subunit 3B
NCBI Official Symbol
GRIN3B
NCBI Official Synonym Symbols
NR3B; GluN3B
UniProt Protein Name
Glutamate receptor ionotropic, NMDA 3B
UniProt Synonym Protein Names
N-methyl-D-aspartate receptor subtype 3B
Protein Family
Glutamate receptor ionotropic
UniProt Gene Name
GRIN3B
UniProt Synonym Gene Names
GluN3B; NMDAR3B; NR3B
UniProt Entry Name
NMD3B_HUMAN
NCBI Protein Information
glutamate receptor ionotropic, NMDA 3B

NCBI Summary for GRIN3B

The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015]
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UniProt Comments for GRIN3B

NMDAR3B: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: postsynaptic membrane; cell soma; dendrite; cell junction; N-methyl-D-aspartate selective glutamate receptor complex

Molecular Function: neurotransmitter binding; extracellular-glutamate-gated ion channel activity; calcium channel activity; N-methyl-D-aspartate selective glutamate receptor activity; glycine binding; cation channel activity; neurotransmitter receptor activity

Biological Process: synaptic transmission, glutamatergic; ionotropic glutamate receptor signaling pathway; regulation of calcium ion transport; protein insertion into membrane
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Research Articles on GRIN3B

1. Authors investigated the significance of a common human genetic variation of the NMDAR NR3B subunit

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GRIN3B antibody

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 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-GRIN3B antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with GRIN3B and Nervous System Diseases
 Brain Diseases Antibodies  >2 publications with GRIN3B and Brain Diseases
 Pain Antibodies  >1 publications with GRIN3B and Pain
 Depressive Disorder Antibodies  >1 publications with GRIN3B and Depressive Disorder
 Cognition Disorders Antibodies  >1 publications with GRIN3B and Cognition Disorders
 Learning Disorders Antibodies  >1 publications with GRIN3B and Learning Disorders
 Necrosis Antibodies  >1 publications with GRIN3B and Necrosis
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