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GRPR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6304548

MBS6304548 is an antibody targeting GRPR. Also known as GRPR, ID (GRPR, Gastrin-releasing peptide receptor, GRP-preferring bombesin receptor) (APC). Reactive in Human. Host: Rabbit. More details

$1120 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GRPR, Polyclonal Antibody
Full Product Name
GRPR, ID (GRPR, Gastrin-releasing peptide receptor, GRP-preferring bombesin receptor) (APC)
Product Gene Name
anti-GRPR antibody
Product Synonym Names
GRPR; Gastrin-releasing peptide receptor; GRP-preferring bombesin receptor
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human GRPR.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
384
OMIM
305670
3D Structure
ModBase 3D Structure for P30550
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 123-152 in the central region of human GRPR. Species sequence homology: mouse and rat
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-GRPR antibody

Antibodies; Receptors
Applications Tested/Suitable for anti-GRPR antibody
Immunohistochemistry (IHC) Paraffin, FLISA
Application Notes for anti-GRPR antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-GRPR antibody

Western Blot analysis in HL-60 cell line lysates (35ug/lane) usingMBS648020. GRPR (arrow) was detected usingMBS648020.
Rabbit Anti-GRPR Polyclonal Antibody – Cat# MBS6304548

Testing Data of anti-GRPR antibody

Rabbit Anti-GRPR Polyclonal Antibody, Testing Data – Cat# MBS6304548

Testing Data of anti-GRPR antibody

Rabbit Anti-GRPR Polyclonal Antibody, Testing Data – Cat# MBS6304548

Product References and Citations for anti-GRPR antibody

1. Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010). 2. Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009). 3. Chao, C., et al. J. Surg. Res. 156(1):26-31(2009). 4. Ananias, H.J., et al. Prostate 69(10):1101-1108(2009). 5. Fleischmann, A., et al. Endocr. Relat. Cancer 16(2):623-633(2009).

Other Notes

Small volumes of anti-GRPR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GRPR. It may not necessarily be applicable to this product.

NCBI GI #
232185
NCBI GeneID
2925
NCBI Accession #
P30550.1
UniProt Primary Accession #
P30550
UniProt Secondary Accession #
B2R910
UniProt Related Accession #
P30550; AAB27329
NCBI Official Full Name
Gastrin-releasing peptide receptor
NCBI Official Synonym Full Names
gastrin-releasing peptide receptor
NCBI Official Symbol
GRPR
NCBI Official Synonym Symbols
BB2
UniProt Protein Name
Gastrin-releasing peptide receptor
UniProt Synonym Protein Names
GRP-preferring bombesin receptor
Protein Family
Gastrin-releasing peptide receptor
UniProt Gene Name
GRPR
UniProt Synonym Gene Names
GRP-R
UniProt Entry Name
GRPR_HUMAN
NCBI Protein Information
gastrin-releasing peptide receptor; GRP-R; bombesin receptor 2; GRP-preferring bombesin receptor

NCBI Summary for GRPR

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for GRPR

GRPR: Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: bombesin receptor activity; peptide receptor activity, G-protein coupled

Biological Process: G-protein coupled receptor protein signaling pathway; cell proliferation; bombesin receptor signaling pathway; regulation of cell proliferation
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Research Articles on GRPR

1. a key mechanism for GRPR-regulated colon cancer cell migration through the Galpha13-PRG-RhoA-ROCK pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GRPR antibody

 Reference Product  PubMed Publications
 GRP antibody  >138 publications with GRPR and GRP
 CCK antibody  >2 publications with GRPR and CCK

Pathways associated with anti-GRPR antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram

Diseases associated with anti-GRPR antibody

 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >69 publications with GRPR and Prostatic Neoplasms
 Lung Neoplasms Antibodies  >22 publications with GRPR and Lung Neoplasms
 Breast Neoplasms Antibodies  >19 publications with GRPR and Breast Neoplasms
 Lung Diseases Antibodies  >16 publications with GRPR and Lung Diseases
 Pain Antibodies  >16 publications with GRPR and Pain
 Inflammation Antibodies  >15 publications with GRPR and Inflammation
 Disease Models, Animal Antibodies  >14 publications with GRPR and Disease Models, Animal
 Memory Disorders Antibodies  >9 publications with GRPR and Memory Disorders
 Brain Diseases Antibodies  >8 publications with GRPR and Brain Diseases
 Hyperplasia Antibodies  >7 publications with GRPR and Hyperplasia

Organs/Tissues associated with anti-GRPR antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >52 publications with GRPR and Brain
 Intestine Antibodies  >4 publications with GRPR and Intestine
 Embryonic Tissue Antibodies  >2 publications with GRPR and Embryonic Tissue
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