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GTF2H4 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643434

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. More details

$880 / 0.05 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GTF2H4, Polyclonal Antibody
Full Product Name
GTF2H4 (General Transcription Factor IIH Subunit 4, Basic Transcription Factor 2 52 kDa Subunit, BTF2 p52, General Transcription Factor IIH Polypeptide 4, TFIIH Basal Transcription Factor Complex p52 Subunit)
Product Gene Name
anti-GTF2H4 antibody
Product Synonym Names
Anti -GTF2H4 (General Transcription Factor IIH Subunit 4, Basic Transcription Factor 2 52 kDa Subunit, BTF2 p52, General Transcription Factor IIH Polypeptide 4, TFIIH Basal Transcription Factor Complex p52 Subunit)
Immunogen Sequence
MESTPSRGLN RVHLQCRNLQ EFLGGLSPGV LDRLYGHPAT CLAVFRELPS LAKNWVMRML FLEQPLPQAA VALWVKKEFS KAQEESTGLL SGLRIWHTQL LPGGLQGLIL NPIFRQNLRI ALLGGGKAWS DDTSQLGPDK HARDVPSLDK YAEERWEVVL HFMVGSPSAA VSQDLAQLLS QAGLMKSTEP GEPPCITSAG FQFLLLDTPA QLWYFMLQYL QTAQSRGMDL VEILSFLFQL SFSTLGKDYS VEGMSDSLLN FLQHLREFGL VFQRKRKSRR YYPTRLAINL SSGVSGAGGT VHQPGFIVVE TNYRLYAYTE SELQIALIAL FSEMLYRFPN MVVAQVTRES VQQAIASGIT AQQIIHFLRT RAHPVMLKQT PVLPPTITDQ IRLWELERDR LRFTEGVLYN QFLSQVDFEL LLAHARELGV LVFENSAKRL MVVTPAGHSD VKRFWKRQKH SS
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human GTF2H4.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
52,186 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (30875957..30881883). Location: 6p21.3
OMIM
601760
3D Structure
ModBase 3D Structure for Q92759
Immunogen
Full length human GTF2H4, aa1-462 (AAH04935).

Product Categories/Family for anti-GTF2H4 antibody

Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-GTF2H4 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-GTF2H4 antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-GTF2H4 antibody

Western Blot analysis of GTF2H4 expression in transfected 293T cell line by GTF2H4 polyclonal antibody. Lane 1: GTF2H4 transfected lysate (50.82kD). Lane 2: Non-transfected lysate.
Mouse Anti-GTF2H4 Polyclonal Antibody – Cat# MBS643434

Immunofluorescence (IF) of anti-GTF2H4 antibody

Immunofluorescence of purified antibody to GTF2H4 on HeLa cell. [antibody concentration 10ug/ml]
Mouse Anti-GTF2H4 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS643434

Other Notes

Small volumes of anti-GTF2H4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GTF2H4 purchase

MBS643434 is an antibody targeting GTF2H4. Also known as GTF2H4 (General Transcription Factor IIH Subunit 4, Basic Transcription Factor 2 52 kDa Subunit, BTF2 p52, General Transcription Factor IIH Polypeptide 4, TFIIH Basal Transcription Factor Complex p52 Subunit). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for GTF2H4. It may not necessarily be applicable to this product.

NCBI GI #
4504201
NCBI GeneID
2968
NCBI Accession #
NP_001508.1
UniProt Primary Accession #
Q92759
UniProt Secondary Accession #
Q76KU4
UniProt Related Accession #
Q92759
GenBank Nucleotide #
NM_001517.4
NCBI Official Full Name
general transcription factor IIH subunit 4
NCBI Official Synonym Full Names
general transcription factor IIH, polypeptide 4, 52kDa
NCBI Official Symbol
GTF2H4
NCBI Official Synonym Symbols
P52; TFB2; TFIIH
UniProt Protein Name
General transcription factor IIH subunit 4
UniProt Synonym Protein Names
Basic transcription factor 2 52 kDa subunit; BTF2 p52; General transcription factor IIH polypeptide 4; TFIIH basal transcription factor complex p52 subunit
Protein Family
General transcription factor
UniProt Gene Name
GTF2H4
UniProt Synonym Gene Names
BTF2 p52
UniProt Entry Name
TF2H4_HUMAN
NCBI Protein Information
general transcription factor IIH subunit 4; BTF2 p52; basic transcription factor 2 52 kDa subunit; general transcription factor IIH polypeptide 4; TFIIH basal transcription factor complex p52 subunit

UniProt Comments for GTF2H4

GTF2H4: Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Belongs to the TFB2 family.

Protein type: DNA repair, damage; Transcription factor

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: nucleoplasm; holo TFIIH complex

Molecular Function: ATP-dependent DNA helicase activity; RNA polymerase subunit kinase activity; DNA-dependent ATPase activity; protein binding; transcription factor activity; protein kinase activity

Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; RNA elongation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; termination of RNA polymerase I transcription; DNA repair; regulation of gene expression, epigenetic; protein amino acid phosphorylation; DNA duplex unwinding; mRNA capping; regulation of transcription, DNA-dependent; nucleotide-excision repair; negative regulation of gene expression, epigenetic; transcription-coupled nucleotide-excision repair; RNA elongation from RNA polymerase II promoter; nucleotide-excision repair, DNA damage removal; gene expression; transcription initiation from RNA polymerase I promoter
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Research Articles on GTF2H4

1. GTF2H4 variants may not be associated with susceptibility to aspirin-exacerbated respiratory disease and obstructive symptoms in asthmatics.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GTF2H4 antibody

 Products by Pathway  Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Dual Incision Reaction In GG-NER Pathway antibodies  Dual Incision Reaction In GG-NER Pathway Diagram
 Dual Incision Reaction In TC-NER Pathway antibodies  Dual Incision Reaction In TC-NER Pathway Diagram
 Eukaryotic Transcription Initiation Pathway antibodies  Eukaryotic Transcription Initiation Pathway Diagram
 Formation Of HIV Elongation Complex In The Absence Of HIV Tat Pathway antibodies  Formation Of HIV Elongation Complex In The Absence Of HIV Tat Pathway Diagram
 Formation Of HIV-1 Elongation Complex Containing HIV-1 Tat Pathway antibodies  Formation Of HIV-1 Elongation Complex Containing HIV-1 Tat Pathway Diagram
 Formation Of RNA Pol II Elongation Complex Pathway antibodies  Formation Of RNA Pol II Elongation Complex Pathway Diagram

Diseases associated with anti-GTF2H4 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with GTF2H4 and Neoplasms
 Uterine Diseases Antibodies  >1 publications with GTF2H4 and Uterine Diseases
 Uterine Cervical Neoplasms Antibodies  >1 publications with GTF2H4 and Uterine Cervical Neoplasms

Organs/Tissues associated with anti-GTF2H4 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with GTF2H4 and Lung
 Eye Antibodies  >1 publications with GTF2H4 and Eye
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