Rabbit Anti-HERV-FRD Polyclonal Antibody – Cat# MBS6306204

Western Blot analysis in NCI-H460 cell line lysates (35ug/lane) usingMBS6011484. This demonstrates that MBS6011484 detected the HERV-FRD protein (arrow).

HERV-FRD Antibody – Rabbit Polyclonal

Name: HERV-FRD Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6306204
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6306204

Human endogenous retroviruses (HERVs) make up approximately 8% of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing… More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HERV-FRD, Polyclonal Antibody

Full Product Name

HERV-FRD, NT (ERVFRD-1, ERVFRDE1, HERV-FRD_6p24.1 provirus ancestral Env polyprotein, Endogenous retrovirus group FRD member 1, Envelope polyprotein, HERV-FRD, Syncytin-2, Surface protein, Transmembrane protein) (MaxLight 550)

Product Gene Name

anti-HERV-FRD antibody

Product Synonym Gene Name

ERVFRDE1

Product Synonym Names

ERVFRD-1; ERVFRDE1; HERV-FRD_6p24.1 provirus ancestral Env polyprotein; Endogenous retrovirus group FRD member 1; Envelope polyprotein; HERV-FRD; Syncytin-2; Surface protein; Transmembrane protein

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

Purity/Purification

Purified by Protein A and Peptide Affinity Chromatography.

Specificity

Recognizes human HERV-FRD.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

59,523 Da

OMIM

610524

3D Structure

ModBase 3D Structure for P60508

Immunogen

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 79-107 in the N-terminal region of human HERV-FRD, UniProt Accession #P60508. Species sequence homology: monkey

Conjugate

MaxLight550

Note

Preservative Free

Product Categories/Family for anti-HERV-FRD antibody

Antibodies; Infectious Disease; HERV

Applications Tested/Suitable for anti-HERV-FRD antibody

FLISA, Western Blot (WB)

Application Notes for anti-HERV-FRD antibody

Applications are based on unconjugated antibody.

Product References and Citations for anti-HERV-FRD antibody

1. Vargas, A., et al. J. Mol. Biol. 392(2):301-318(2009). 2. Chen, C.P., et al. Biol. Reprod. 79(5):815-823(2008). 3. Malassine, A., et al. Retrovirology 5, 6 (2008). 4. Mangeney, M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(51):20534-20539(2007). 5. Malassine, A., et al. Placenta 28 (2-3), 185-191 (2007).

Other Notes

Small volumes of anti-HERV-FRD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HERV-FRD purchase

MBS6306204 is an antibody targeting HERV-FRD. Also known as HERV-FRD, NT (ERVFRD-1, ERVFRDE1, HERV-FRD_6p24.1 provirus ancestral Env polyprotein, Endogenous retrovirus group FRD member 1, Envelope polyprotein, HERV-FRD, Syncytin-2, Surface protein, Transmembrane protein) (MaxLight 550). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HERV-FRD. It may not necessarily be applicable to this product.

NCBI GI #

46485773

NCBI GeneID

405754

NCBI Accession #

NP_997465.1

UniProt Primary Accession #

P60508

UniProt Related Accession #

P60508

GenBank Nucleotide #

NM_207582.2

NCBI Official Full Name

syncytin-2 preproprotein

NCBI Official Synonym Full Names

endogenous retrovirus group FRD member 1, envelope

NCBI Official Symbol

ERVFRD-1

NCBI Official Synonym Symbols

envFRD; UNQ6191; ERVFRDE1; GLLL6191; HERV-FRD; HERV-W/FRD

UniProt Protein Name

Syncytin-2

UniProt Synonym Protein Names

Endogenous retrovirus group FRD member 1; Envelope polyprotein; HERV-FRD; HERV-FRD_6p24.1 provirus ancestral Env polyprotein

Protein Family

Syncytin

UniProt Gene Name

ERVFRD-1

UniProt Synonym Gene Names

ERVFRDE1; SU; TM

NCBI Protein Information

syncytin-2

NCBI Summary for HERV-FRD

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012]

UniProt Comments for HERV-FRD

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732).

Research Articles on HERV-FRD

1. N-glycans at residues 133, 312, 332 and 443 of syncytin-2 are required for optimal fusion induction, and that single-nucleotide polymorphism C46R, N118S, T367M, R417H, V483I and T522M can alter the fusogenic function of syncytin-2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HERV-FRD antibody

Reference Product	PubMed Publications
GCM1 antibody	>57 publications with HERV-FRD and GCM1
SLC1A5 antibody	>51 publications with HERV-FRD and SLC1A5
OXGR1 antibody	>6 publications with HERV-FRD and OXGR1
CLEC10A antibody	>5 publications with HERV-FRD and CLEC10A
MFSD2A antibody	>5 publications with HERV-FRD and MFSD2A

Diseases associated with anti-HERV-FRD antibody

Disease Name	Pubmed Publications
Respiratory Tract Diseases Antibodies	>324075 publications with HERV-FRD and Respiratory Tract Diseases
Carcinoma Antibodies	>273779 publications with HERV-FRD and Carcinoma
Lung Diseases Antibodies	>233500 publications with HERV-FRD and Lung Diseases
Gastrointestinal Diseases Antibodies	>225921 publications with HERV-FRD and Gastrointestinal Diseases
Drug Toxicity Antibodies	>180069 publications with HERV-FRD and Drug Toxicity
Adenocarcinoma Antibodies	>121507 publications with HERV-FRD and Adenocarcinoma
Breast Neoplasms Antibodies	>91832 publications with HERV-FRD and Breast Neoplasms
Anemia Antibodies	>58720 publications with HERV-FRD and Anemia
Colorectal Neoplasms Antibodies	>58251 publications with HERV-FRD and Colorectal Neoplasms
Renal Insufficiency Antibodies	>50431 publications with HERV-FRD and Renal Insufficiency

Organs/Tissues associated with anti-HERV-FRD antibody

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>93732 publications with HERV-FRD and Connective Tissue
Testis Antibodies	>34497 publications with HERV-FRD and Testis
Placenta Antibodies	>30908 publications with HERV-FRD and Placenta
Parathyroid Antibodies	>23846 publications with HERV-FRD and Parathyroid
Uncharacterized Tissue Antibodies	>753 publications with HERV-FRD and Uncharacterized Tissue