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HJURP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6307002

HJURP is a centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules… More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HJURP, Polyclonal Antibody
Full Product Name
HJURP, CT (HJURP, FAKTS, FLEG1, URLC9, Holliday junction recognition protein, 14-3-3-associated AKT substrate, Fetal liver-expressing gene 1 protein, Up-regulated in lung cancer 9) (Biotin)
Product Gene Name
anti-HJURP antibody
Product Synonym Names
HJURP; FAKTS; FLEG1; URLC9; Holliday junction recognition protein; 14-3-3-associated AKT substrate; Fetal liver-expressing gene 1 protein; Up-regulated in lung cancer 9
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
83,539 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (234745486..234763212, complement). Location: 2q37.1
OMIM
612667
3D Structure
ModBase 3D Structure for Q8NCD3
Immunogen
HJURP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 558-588 amino acids from the C-terminal region of human HJURP.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-HJURP antibody

Antibodies; Cancer Markers
Applications Tested/Suitable for anti-HJURP antibody
Flow Cytometry (FC/FACS), ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-HJURP antibody
FC/FACS: 1:10-50
ELISA: 1:1,000
IHC: 1:10-50
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-HJURP antibody

HJURP Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the HJURP antibody detected the HJURP protein (arrow).
Rabbit Anti-HJURP Polyclonal Antibody – Cat# MBS6307002

Immunohistochemistry (IHC) of anti-HJURP antibody

HJURP Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human thyroid tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HJURP Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-HJURP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6307002

Flow Cytometry (FC/FACS) of anti-HJURP antibody

HJURP Antibody (C-term) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-HJURP Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6307002

Product References and Citations for anti-HJURP antibody

Sebastiani, P., et al. Science (2010). In press: Shuaib, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(4):1349-1354(2010). Hu, Z., et al. Breast Cancer Res. 12 (2), R18 (2010): Dunleavy, E.M., et al. Cell 137(3):485-497(2009). Foltz, D.R., et al. Cell 137(3):472-484(2009).

Other Notes

Small volumes of anti-HJURP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HJURP purchase

MBS6307002 is an antibody targeting HJURP. Also known as HJURP, CT (HJURP, FAKTS, FLEG1, URLC9, Holliday junction recognition protein, 14-3-3-associated AKT substrate, Fetal liver-expressing gene 1 protein, Up-regulated in lung cancer 9) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HJURP. It may not necessarily be applicable to this product.

NCBI GI #
83816964
NCBI GeneID
55355
NCBI Accession #
NP_060880.3
UniProt Primary Accession #
Q8NCD3
UniProt Secondary Accession #
Q9BUT2; Q9NSL8; A8IRH5; B4DWR0; B4DZV4
UniProt Related Accession #
Q8NCD3
GenBank Nucleotide #
NM_018410.4
NCBI Official Full Name
Holliday junction recognition protein isoform a
NCBI Official Synonym Full Names
Holliday junction recognition protein
NCBI Official Symbol
HJURP
NCBI Official Synonym Symbols
FAKTS; URLC9; hFLEG1
UniProt Protein Name
Holliday junction recognition protein
UniProt Synonym Protein Names
14-3-3-associated AKT substrate; Fetal liver-expressing gene 1 protein; Up-regulated in lung cancer 9
Protein Family
Holliday junction recognition protein
UniProt Gene Name
HJURP
UniProt Synonym Gene Names
FAKTS; FLEG1; URLC9
UniProt Entry Name
HJURP_HUMAN
NCBI Protein Information
Holliday junction recognition protein; fetal liver expressing gene 1; up-regulated in lung cancer 9; 14-3-3-associated AKT substrate; fetal liver-expressing gene 1 protein

Research Articles on HJURP

1. Downregulation of HJURP in young cells led to premature senescence. p53 knockdown, but not p16 knockdown, abolished senescence phenotypes caused by HJURP reduction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HJURP antibody

 Reference Product  PubMed Publications
 CENPA antibody  >2 publications with HJURP and CENPA

Pathways associated with anti-HJURP antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway antibodies  Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway Diagram
 Nucleosome Assembly Pathway antibodies  Nucleosome Assembly Pathway Diagram

Diseases associated with anti-HJURP antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7 publications with HJURP and Neoplasms
 Breast Neoplasms Antibodies  >2 publications with HJURP and Breast Neoplasms
 Brain Diseases Antibodies  >1 publications with HJURP and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with HJURP and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >1 publications with HJURP and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >1 publications with HJURP and Neoplasms, Experimental

Organs/Tissues associated with anti-HJURP antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with HJURP and Lung
 Brain Antibodies  >2 publications with HJURP and Brain
 Vascular Antibodies  >2 publications with HJURP and Vascular
 Muscle Antibodies  >1 publications with HJURP and Muscle
 Lymph Node Antibodies  >1 publications with HJURP and Lymph Node
 Lymph Antibodies  >1 publications with HJURP and Lymph
 Blood Antibodies  >1 publications with HJURP and Blood
 Testis Antibodies  >1 publications with HJURP and Testis
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