HOMER2 Antibody – Rabbit Polyclonal

HOMER2: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Belongs to the Homer family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Actin-binding

Chromosomal Location of Human Ortholog: 15q24.3

Cellular Component: nucleoplasm; postsynaptic membrane; cell soma; apical part of cell; dendrite; cytoplasm; plasma membrane; nucleolus; nucleus; cell junction

Molecular Function: protein domain specific binding; protein homodimerization activity; metabotropic glutatmate receptor binding; protein heterodimerization activity; GKAP/Homer scaffold activity; actin binding

Biological Process: chemical homeostasis within a tissue; behavioral response to cocaine; metabotropic glutamate receptor signaling pathway; regulation of G-protein coupled receptor protein signaling pathway