HS6ST1 Antibody – Sheep Polyclonal

Heparan Sulfate is a highly sulfated polysaccharide that can be found on cell surface and extrracellular matrix.It is usually covalently attached to a protein core as the glycan component of a proteoglycan. Heparan Sulfate interacts with a variety of proteins,such as growth factors, protease inhibitors, cytokines, lipoprotein lipase and viral envelope proteins, thus plays roles from cell growth, cell differentiation, cell motility, blood coagulation, lipid metabolism to viral infection (1,2).Heparan Sulfate consists of repeating residues of uronic acid and N-acetyl glucosamine. The uronic acid residues can be sulfated at 2-O position by Heparan Sulfate 2-0 Sulfotransferase (HS2ST). The N-acetyl glucosamine residues can be sulfated at N-, 3-O, and 6-O positions by N-deacetylase/N-sulfotransferases (NDSTs), Heparan Sulfate 3-O and 6-O sulfotransferases (HS3STs and HS6STs) respectively. However, the reactions catalyzed by these sulfotransferases are normally incomplete on the whole chain of Heparan Sulfate. As a result, Heparan Sulfate displays enormous sequence diversity that allows it to interact with a wide spect rum of proteins differently. Among three HS6STs, HS6ST1is the first to be cloned(3).Mice deficient of the HS6ST1 homologue gene showed embryonic lethality(4).

Small volumes of anti-HS6ST1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6009962 is an antibody targeting HS6ST1. Also known as HS6ST1 (Heparan-sulfate 6-O-sulfotransferase 1, DKFZp547H098, FLJ25392, Heparan-sulfate 6-O-sulfotransferase 1, HS6ST, HS6ST-1, MGC116899, MGC116901). Reactive in Human. Host: Sheep.