• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

HSPC142 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6481195

MBS6481195 is an antibody targeting HSPC142. Also known as HSPC142 (BRCA1-A Complex Subunit MERIT40, Chromosome 19 Open Reading Frame 62, C19orf62, FLJ20571, Mediator of RAP80 Interactions and Targeting Subunit of 40kD, MERIT40, New Component of the BRCA1-A… More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HSPC142, Polyclonal Antibody
Full Product Name
HSPC142 (BRCA1-A Complex Subunit MERIT40, Chromosome 19 Open Reading Frame 62, C19orf62, FLJ20571, Mediator of RAP80 Interactions and Targeting Subunit of 40kD, MERIT40, New Component of the BRCA1-A Complex, NBA1) (AP)
Product Gene Name
anti-HSPC142 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human HSPC142.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
36kDa
OMIM
612766
3D Structure
ModBase 3D Structure for Q9NWV8
Immunogen
Synthetic peptide selected from the center region of human HSPC142 (KLH).
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-HSPC142 antibody

Antibodies; DNA Replication; Repair
Applications Tested/Suitable for anti-HSPC142 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-HSPC142 antibody
WB: 1:50-1:100
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Immunohistochemistry (IHC) of anti-HSPC142 antibody

Formalin-fixed and paraffin-embedded human brain reacted with HSPC142 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-HSPC142 Polyclonal Antibody – Cat# MBS6481195

Western Blot (WB) of anti-HSPC142 antibody

Western blot analysis of HSPC142 Antibody (Center) in MDA-MB231 cell line lysates (35ug/lane). HSPC142 (arrow) was detected using the purified Pab.
Rabbit Anti-HSPC142 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6481195

Flow Cytometry (FC/FACS) of anti-HSPC142 antibody

Flow cytometric analysis of MDA-MB468 cells using HSPC142 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram)FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-HSPC142 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6481195

Product References and Citations for anti-HSPC142 antibody

1. Shao, G., et.al., Genes Dev. 23(6), 740-754 (2009). 2. Ewing, R.M., et.al., Mol. Syst. Biol. 3, 89 (2007).

Other Notes

Small volumes of anti-HSPC142 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HSPC142. It may not necessarily be applicable to this product.

NCBI GI #
75709192
NCBI GeneID
29086
NCBI Accession #
NP_054892
UniProt Primary Accession #
Q9NWV8
UniProt Related Accession #
Q9NWV8
GenBank Nucleotide #
NM_014173
NCBI Official Full Name
BRISC and BRCA1-A complex member 1 isoform 1
NCBI Official Synonym Full Names
BRISC and BRCA1 A complex member 1
NCBI Official Symbol
BABAM1
NCBI Official Synonym Symbols
NBA1; HSPC142; MERIT40; C19orf62
UniProt Protein Name
BRISC and BRCA1-A complex member 1
UniProt Synonym Protein Names
Mediator of RAP80 interactions and targeting subunit of 40 kDa
UniProt Gene Name
BABAM1
UniProt Entry Name
BABA1_HUMAN
NCBI Protein Information
BRISC and BRCA1-A complex member 1

UniProt Comments for HSPC142

NBA1: a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes. Two alternatively spliced human isoforms have been reported.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: double-strand break repair; double-strand break repair via nonhomologous end joining; G2/M transition DNA damage checkpoint; positive regulation of DNA repair; response to ionizing radiation
Show more

Research Articles on HSPC142

1. Genetic variants in NBA1 may be an important genetic determinant of triple-negative breast cancer susceptibility.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HSPC142 antibody

 Reference Product  PubMed Publications
 BRCA1 antibody  >14 publications with HSPC142 and BRCA1
 BRCC3 antibody  >6 publications with HSPC142 and BRCC3
 FAM175A antibody  >6 publications with HSPC142 and FAM175A
 BRE antibody  >4 publications with HSPC142 and BRE
 BARD1 antibody  >2 publications with HSPC142 and BARD1
 FAM175B antibody  >1 publications with HSPC142 and FAM175B

Pathways associated with anti-HSPC142 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 DNA Double Strand Break Response Pathway antibodies  DNA Double Strand Break Response Pathway Diagram
 DNA Double-Strand Break Repair Pathway antibodies  DNA Double-Strand Break Repair Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 G2/M Checkpoints Pathway antibodies  G2/M Checkpoints Pathway Diagram
 G2/M DNA Damage Checkpoint Pathway antibodies  G2/M DNA Damage Checkpoint Pathway Diagram
 HDR Through Homologous Recombination (HR) Or Single Strand Annealing (SSA) Pathway antibodies  HDR Through Homologous Recombination (HR) Or Single Strand Annealing (SSA) Pathway Diagram
 Homology Directed Repair Pathway antibodies  Homology Directed Repair Pathway Diagram
 Nonhomologous End-Joining (NHEJ) Pathway antibodies  Nonhomologous End-Joining (NHEJ) Pathway Diagram

Diseases associated with anti-HSPC142 antibody

 Disease Name  Pubmed Publications
 Ovarian Neoplasms Antibodies  >2 publications with HSPC142 and Ovarian Neoplasms
 Memory Disorders Antibodies  >1 publications with HSPC142 and Memory Disorders
 Adenocarcinoma Antibodies  >1 publications with HSPC142 and Adenocarcinoma

Organs/Tissues associated with anti-HSPC142 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >2 publications with HSPC142 and Nerve
 Ovary Antibodies  >1 publications with HSPC142 and Ovary
 Brain Antibodies  >1 publications with HSPC142 and Brain
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000