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ICMT Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6483663

MBS6483663 is an antibody targeting ICMT. Also known as ICMT, CT (Protein-S-isoprenylcysteine O-methyltransferase, Isoprenylcysteine Carboxylmethyltransferase, Prenylcysteine Carboxyl Methyltransferase, pcCMT, Prenylated Protein Carboxyl Methyltransferase,… More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ICMT, Polyclonal Antibody
Full Product Name
ICMT, CT (Protein-S-isoprenylcysteine O-methyltransferase, Isoprenylcysteine Carboxylmethyltransferase, Prenylcysteine Carboxyl Methyltransferase, pcCMT, Prenylated Protein Carboxyl Methyltransferase, PPMT, ICMT, PCCMT) (MaxLight 550)
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein G Affinity Chromatography.
Specificity
Recognizes human ICMT.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
32kDa
OMIM
AF064084 mRNA
3D Structure
ModBase 3D Structure for O60725
Immunogen
Synthetic peptide selected from the C-terminal region of human ICMT (KLH).
Conjugate
MaxLight550
Note
Preservative Free
Applications Tested/Suitable for anti-ICMT antibody
Western Blot (WB), FLISA
Application Notes for anti-ICMT antibody
WB: 1:100-1:500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-ICMT antibody

1. Bergo, M.O., et al., J. Clin. Invest. 113(4):539-550 (2004). 2. Ahmad, M., et al., Arterioscler. Thromb. Vasc. Biol. 22(5):759-764 (2002). 3. Van Dessel, G.A., et al., Int. J. Biochem. Cell Biol. 34(5):477-486 (2002). 4. Dai, Q., et al., J. Biol. Chem. 273(24):15030-15034 (1998).

Other Notes

Small volumes of anti-ICMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ICMT. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
protein-S-isoprenylcysteine O-methyltransferase
NCBI Official Synonym Full Names
isoprenylcysteine carboxyl methyltransferase
NCBI Official Symbol
ICMT
NCBI Official Synonym Symbols
PCMT; PPMT; PCCMT; HSTE14; MST098; MSTP098
UniProt Protein Name
Protein-S-isoprenylcysteine O-methyltransferase
UniProt Synonym Protein Names
Isoprenylcysteine carboxylmethyltransferase; Prenylated protein carboxyl methyltransferase; PPMT; Prenylcysteine carboxyl methyltransferase; pcCMT
UniProt Gene Name
ICMT
UniProt Synonym Gene Names
PCCMT; PPMT; pcCMT
NCBI Protein Information
protein-S-isoprenylcysteine O-methyltransferase

NCBI Summary for ICMT

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
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UniProt Comments for ICMT

ICMT: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. Belongs to the isoprenylcysteine O-methyltransferase family.

Protein type: EC 2.1.1.100; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Methyltransferase; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1p36.31

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; membrane

Molecular Function: protein C-terminal carboxyl O-methyltransferase activity; protein-S-isoprenylcysteine O-methyltransferase activity

Biological Process: C-terminal protein methylation; cellular protein modification process; post-translational protein modification; protein targeting to membrane
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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