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ICOSLG Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6309107

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local… More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ICOSLG, Polyclonal Antibody
Full Product Name
ICOSLG, CT (ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653, ICOS ligand, B7 homolog 2, B7-like protein Gl50, B7-related protein 1, CD275) (MaxLight 490)
Product Gene Name
anti-ICOSLG antibody
Product Synonym Names
ICOSLG; B7H2; B7RP1; ICOSL; KIAA0653; ICOS ligand; B7 homolog 2; B7-like protein Gl50; B7-related protein 1; CD275
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human ICOSLG.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
33,349 Da
Chromosome Location
Chromosome: 21; NC_000021.8 (45646721..45660834, complement). Location: 21q22.3
OMIM
AF199028 mRNA
3D Structure
ModBase 3D Structure for O75144
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 217-246 in the C-terminal region of human ICOSLG, UniProt Accession #NP_056074.1; O75144.
Conjugate
MaxLight490
Note
Preservative Free

Product Categories/Family for anti-ICOSLG antibody

Antibodies; CD Markers
Applications Tested/Suitable for anti-ICOSLG antibody
Western Blot (WB), FLISA
Application Notes for anti-ICOSLG antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ICOSLG antibody

Western Blot analysis in HL-60 cell line lysates (35ug/lane) usingMBS6004943. This demonstrates that MBS6004943 detected the ICOSLG protein (arrow).
Rabbit Anti-ICOSLG Polyclonal Antibody – Cat# MBS6309107

Product References and Citations for anti-ICOSLG antibody

1. Shimada, M., et al. Hum. Genet. 128(4):433-441(2010). 2. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). 3. Wang, K., et al. Hum. Mol. Genet. 19(10):2059-2067(2010). 4. Pan, F., et al. Immunogenetics 62(4):237-251(2010). 5. Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010).

Other Notes

Small volumes of anti-ICOSLG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ICOSLG purchase

MBS6309107 is an antibody targeting ICOSLG. Also known as ICOSLG, CT (ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653, ICOS ligand, B7 homolog 2, B7-like protein Gl50, B7-related protein 1, CD275) (MaxLight 490). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ICOSLG. It may not necessarily be applicable to this product.

NCBI GI #
27477039
NCBI GeneID
23308
NCBI Accession #
NP_056074.1
UniProt Primary Accession #
O75144
UniProt Secondary Accession #
Q9HD18; Q9NRQ1
UniProt Related Accession #
O75144
GenBank Nucleotide #
NM_015259.4
NCBI Official Full Name
ICOS ligand
NCBI Official Synonym Full Names
inducible T-cell co-stimulator ligand
NCBI Official Symbol
ICOSLG
NCBI Official Synonym Symbols
B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
UniProt Protein Name
ICOS ligand
UniProt Synonym Protein Names
B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD_antigen: CD275
Protein Family
ICOS ligand
UniProt Gene Name
ICOSLG
UniProt Synonym Gene Names
B7H2; B7RP1; ICOSL; KIAA0653; B7-H2; B7RP-1
NCBI Protein Information
ICOS ligand; B7 homolog 2; B7 homologue 2; B7-like protein Gl50; B7-related protein 1; transmembrane protein B7-H2 ICOS ligand

UniProt Comments for ICOSLG

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ICOSLG antibody

 Reference Product  PubMed Publications
 ICOS antibody  >41 publications with ICOSLG and ICOS

Pathways associated with anti-ICOSLG antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram

Diseases associated with anti-ICOSLG antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with ICOSLG and Inflammation
 Carcinoma Antibodies  >4 publications with ICOSLG and Carcinoma
 Colitis, Ulcerative Antibodies  >2 publications with ICOSLG and Colitis, Ulcerative
 Diabetes Mellitus, Type 2 Antibodies  >1 publications with ICOSLG and Diabetes Mellitus, Type 2
 Psoriasis Antibodies  >1 publications with ICOSLG and Psoriasis
 Drug Toxicity Antibodies  >1 publications with ICOSLG and Drug Toxicity
 Congenital Abnormalities Antibodies  >1 publications with ICOSLG and Congenital Abnormalities
 Nervous System Malformations Antibodies  >1 publications with ICOSLG and Nervous System Malformations
 Thyroid Diseases Antibodies  >1 publications with ICOSLG and Thyroid Diseases
 Celiac Disease Antibodies  >1 publications with ICOSLG and Celiac Disease

Organs/Tissues associated with anti-ICOSLG antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >47 publications with ICOSLG and Blood
 Kidney Antibodies  >4 publications with ICOSLG and Kidney
 Heart Antibodies  >4 publications with ICOSLG and Heart
 Lymph Node Antibodies  >4 publications with ICOSLG and Lymph Node
 Brain Antibodies  >3 publications with ICOSLG and Brain
 Connective Tissue Antibodies  >2 publications with ICOSLG and Connective Tissue
 Liver Antibodies  >2 publications with ICOSLG and Liver
 Skin Antibodies  >2 publications with ICOSLG and Skin
 Lung Antibodies  >2 publications with ICOSLG and Lung
 Placenta Antibodies  >1 publications with ICOSLG and Placenta
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