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IFI30 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9439750

The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an… More details

$435 / 0.1 mL (Biotin) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IFI30, Polyclonal Antibody
Full Product Name
IFI30 Polyclonal Conjugated Antibody
Product Gene Name
anti-IFI30 antibody
Product Synonym Names
IFI30 Conjugated Antibody; IFI30; GILT; IFI-30; IP-30; IP30; IFI30; lysosomal thiol reductase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
Purity/Purification
Affinity purification
Preparation and Storage
Store at 4 degree C for 6 months.
Molecular Weight
27,964 Da
OMIM
604664
3D Structure
ModBase 3D Structure for P13284
Immunogen
Recombinant fusion protein of human IFI30 (NP_006323.2).
Conjugation
Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
Excitation Emission
AF350: 346nm/442nm
Applications Tested/Suitable for anti-IFI30 antibody
Most Applications
Application Notes for anti-IFI30 antibody
Suggested Dilution:
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000

Other Notes

Small volumes of anti-IFI30 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFI30 purchase

MBS9439750 is an antibody targeting IFI30. Also known as IFI30 Polyclonal Conjugated Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IFI30. It may not necessarily be applicable to this product.

NCBI GI #
29150261
NCBI GeneID
10437
NCBI Accession #
NP_006323.2
UniProt Primary Accession #
P13284
UniProt Secondary Accession #
Q76MF9; Q8NEI4; Q8WU77; Q9UL08
UniProt Related Accession #
P13284
GenBank Nucleotide #
NM_006332.4
NCBI Official Full Name
gamma-interferon-inducible lysosomal thiol reductase preproprotein
NCBI Official Synonym Full Names
interferon, gamma-inducible protein 30
NCBI Official Symbol
IFI30
NCBI Official Synonym Symbols
GILT; IP30; IP-30; IFI-30
UniProt Protein Name
Gamma-interferon-inducible lysosomal thiol reductase
UniProt Synonym Protein Names
Gamma-interferon-inducible protein IP-30; Legumaturain
Protein Family
Gamma-interferon-inducible lysosomal thiol reductase
UniProt Gene Name
IFI30
UniProt Synonym Gene Names
GILT; IP30
UniProt Entry Name
GILT_HUMAN
NCBI Protein Information
gamma-interferon-inducible lysosomal thiol reductase; gamma-interferon-inducible protein IP-30; interferon gamma-inducible protein 30 preproprotein; legumaturain

UniProt Comments for IFI30

IFI30: Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation. Belongs to the GILT family.

Protein type: Secreted, signal peptide; EC 1.8.-.-; Secreted

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: lysosomal lumen; intracellular membrane-bound organelle; lysosome; cytoplasm; extracellular region; plasma membrane; cell junction

Molecular Function: oxidoreductase activity, acting on sulfur group of donors

Biological Process: protein stabilization; negative regulation of fibroblast proliferation; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class II
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Research Articles on IFI30

1. this review discusses recent studies that have advanced our understanding of the role of GILT in antigen processing and revealed surprising new functions for the enzyme.[review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IFI30 antibody

 Reference Product  PubMed Publications
 IRF1 antibody  >4 publications with IFI30 and IRF1
 HLA-A antibody  >3 publications with IFI30 and HLA-A
 IRF8 antibody  >1 publications with IFI30 and IRF8
 HLA-B antibody  >1 publications with IFI30 and HLA-B

Pathways associated with anti-IFI30 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram

Diseases associated with anti-IFI30 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >11 publications with IFI30 and Inflammation
 Nervous System Diseases Antibodies  >5 publications with IFI30 and Nervous System Diseases
 Disease Models, Animal Antibodies  >4 publications with IFI30 and Disease Models, Animal
 Necrosis Antibodies  >4 publications with IFI30 and Necrosis
 Brain Diseases Antibodies  >3 publications with IFI30 and Brain Diseases
 Liver Diseases Antibodies  >2 publications with IFI30 and Liver Diseases
 Fibrosis Antibodies  >2 publications with IFI30 and Fibrosis
 Neoplasms, Experimental Antibodies  >2 publications with IFI30 and Neoplasms, Experimental
 Hyperglycemia Antibodies  >2 publications with IFI30 and Hyperglycemia
 Cell Transformation, Neoplastic Antibodies  >1 publications with IFI30 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-IFI30 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >31 publications with IFI30 and Blood
 Spleen Antibodies  >4 publications with IFI30 and Spleen
 Skin Antibodies  >4 publications with IFI30 and Skin
 Thymus Antibodies  >4 publications with IFI30 and Thymus
 Vascular Antibodies  >3 publications with IFI30 and Vascular
 Heart Antibodies  >2 publications with IFI30 and Heart
 Brain Antibodies  >2 publications with IFI30 and Brain
 Intestine Antibodies  >2 publications with IFI30 and Intestine
 Muscle Antibodies  >2 publications with IFI30 and Muscle
 Adipose Tissue Antibodies  >2 publications with IFI30 and Adipose Tissue
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